Day: March 21, 2024

Synthetic Route of C12H12N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Chemical sensors based on nano-sized lanthanide-grafted periodic mesoporous organosilica hybrid materials. Author is Kaczmarek, Anna M.; Van Der Voort, Pascal.

In this work authors introduce the use of nano-sized (50-70 nm) lanthanide-grafted periodic mesoporous organosilicas for both metal ion sensing and solvent sensing. For this study a PMO constructed from the N,N-bis(trimethoxysilylpropyl)-2,6-pyridine dicarboxamide linker and tetra-Et orthosilicate (at a 5 : 95 ratio) was employed. This material was grafted with Eu3+, Tb3+ or a mixture of Eu3+-Tb3+ chloride salts to obtain strongly emitting nano-sized luminescence materials. To further enhance the luminescence properties of the materials two different co-ligands were used – 1,10-phenanthroline (phen) and 5,5′-dimethyl-2,2′-dipyridyl (bpy). The luminescence properties of the developed series of hybrid materials were studied in detail in the solid-state and after dispersing in water. The materials were investigated for their use as ion sensors, with the Eu3+ and Tb3+ phen and bpy co-grafted materials showing selective “”turn on”” fluorescence for Pb2+ and Cr3+ ions (at a 10 ppm concentration of the ions). The Eu3+-Tb3+ co-grafted materials showed solvatochromism and could be used as a solvent sensor to distinguish between protic and aprotic solvents.

After consulting a lot of data, we found that this compound(1762-34-1)Synthetic Route of C12H12N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer, published in 2020-11-28, which mentions a compound: 1762-34-1, Name is 5,5′-Dimethyl-2,2′-bipyridine, Molecular C12H12N2, Electric Literature of C12H12N2.

In this study, we newly designed and synthesized a small library of ten structurally related C,N-cyclometalated ruthenium(II) complexes containing various pyridine-functionalized NHC ligand and chelating bipyridyl ligands (e.g., 2,2′-bipyridine, 5,5′-dimethyl-2,2′-bipyridine, and 1,10-phenanthroline (phen)). The complexes were well characterized by NMR, electrospray ionization-mass spectrometry, and single-crystal X-ray structure analyses. Among the new ruthenium(II) derivatives, we identified that the complex Ru8 bearing bulky moieties (i.e., phen and pentamethyl benzene) had the most potent cytotoxicity against all tested cancer cell lines, generating dose- and cell line-dependent IC50 values at the range of 3.3-15.0μM. More significantly, Ru8 not only efficiently inhibited the metastasis process against invasion and migration of tumor cells but also exhibited potent antivascular effects by suppressing HUVEC cells migration and tube formation in vitro and blocking vessel generation in vivo (chicken chorioallantoic membrane model). In a metastatic A2780 tumor xenograft-bearing mouse model, administration of Ru8 outperformed antimetastatic agent NAMI-A and clin. approved cisplatin in terms of antitumor efficacy and inhibition of metastases to other organs. Overall, these data provided compelling evidence that the new cyclometalated ruthenium complex Ru8 is an attractive agent because of synergistically suppressing bulky tumors and metastasized tumor nudes. Therefore, the complex Ru8 deserves further investigations.

After consulting a lot of data, we found that this compound(1762-34-1)Electric Literature of C12H12N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem