In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria, published in 2020-02-29, which mentions a compound: 1762-34-1, mainly applied to antibacterial copper silica nanoparticle; Antibacterial activity; Copper; Electrochemistry; Mesoporous silica; ROS; SBA-15, Quality Control of 5,5′-Dimethyl-2,2′-bipyridine.
A series of copper-functionalized SBA-15 (Santa Barbara Amorphous) materials containing the ligands triethoxysilylpropylmaleamic acid (maleamic) or triethoxy-3-(2-imidazolin-1-yl)propylsilane (imidazoline) have been prepared The nanostructured silica-based systems SBA-maleamic, SBA-imidazoline, SBA-maleamic-Cu and SBA-imidazoline-Cu were characterized by several methods observing that the functionalization took place mainly inside the pores of the mesoporous system. The antimicrobial behavior of the synthesized materials against Staphylococcus aureus and Escherichia coli was tested observing a very potent activity of the copper-functionalized systems (min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) values for SBA-maleamic-Cu of ca. 31.25 μg/mL, which correspond with ca. 1.13 μg/mL of Cu). A study of the oxidative stress promoted by the synthesized materials showed that the SBA-maleamic-Cu and the SBA-imidazoline-Cu were able to increase the reactive oxygen species (ROS) production in S. aureus by 427% and 373%, resp., while this increase was slightly lower in E. coli (387 and 324%, resp.). Furthermore, an electrochem. study was carried out in order to determine if these materials interact with lysine or alanine to validate a potential antimicrobial mechanism based on the inhibition of the synthesis of the peptidoglycan of the bacterial wall. Finally, these studies were also performed to determine the potential interaction of the copper-containing materials with glutathione in order to assess if they are able to perturb the metabolism of this tripeptide.
Although many compounds look similar to this compound(1762-34-1)Quality Control of 5,5′-Dimethyl-2,2′-bipyridine, numerous studies have shown that this compound(SMILES:CC1=CN=C(C=C1)C1=NC=C(C)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.