Day: February 15, 2022

An article Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-b]pyridines WOS:000585952100032 published article about MOLECULAR-DYNAMICS SIMULATIONS; DRUG DISCOVERY; RESISTANCE; ACCURACY; AMBER; GAMETOCYTES; DESIGN in [Hammill, Jared T.; Rice, Amy L.; Falade, Mofolusho O.; Guy, R. Kiplin] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40508 USA; [Sigal, Martina] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, 332 N Lauderdale St, Memphis, TN 38105 USA; [Eagon, Scott; Ahn, Kevin J.; Tryhorn, Julia E.; Belanger, Briana; Chaplan, Cory A.; Loop, Lauren; Kashtanova, Anna S.; Wilkinson, Steven P.; Takahashi, Rei; Kim, Katie; Cheung, Ashley; DiBernardo, Celine] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA; [Koch, Grant] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA; [Yniguez, Kenya] SRI Int, Menlo Pk, CA 94025 USA; [Lazaro, Horacio; Kimball, Joshua J.] Promega Biosci, San Luis Obispo, CA 93401 USA; [Winzeler, Elizabeth A.; Eribez, Korina; Mittal, Nimisha] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA; [Gamo, Francisco-Javier; Crespo, Benigno] GlaxoSmithKline, DDW, Global Hlth, Madrid 28760, Spain; [Churchyard, Alisje; Garcia-Barbazan, Irene; Baum, Jake] Imperial Coll London, Dept Life Sci, London SW7 2AZ, England; [Anderson, Marc O.] San Francisco State Univ, Dept Chem & Biochem, San Francisco, CA 94132 USA; [Laleu, Benoit] Med Malaria Venture MMV, CH-1215 Geneva, Switzerland in 2020.0, Cited 56.0. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines targeting Plasmodium falciparum, the deadliest species of the malaria parasite. Hit compounds in this series display sub-micromolar in vitro activity against the intraerythrocytic stage of the parasite as well as little to no toxicity against the human fibroblast BJ and liver HepG2 cell lines. In addition, our hit compounds show good activity against the liver stage of the parasite but little activity against the gametocyte stage. Parasitological profiles, including rate of killing, docking, and molecular dynamics studies, suggest that our compounds may target the Q(o) binding site of cytochrome bc(1).

Welcome to talk about 100-19-6, If you have any questions, you can contact Eagon, S; Hammill, JT; Sigal, M; Ahn, KJ; Tryhorn, JE; Koch, G; Belanger, B; Chaplan, CA; Loop, L; Kashtanova, AS; Yniguez, K; Lazaro, H; Wilkinson, SP; Rice, AL; Falade, MO; Takahashi, R; Kim, K; Cheung, A; DiBernardo, C; Kimball, JJ; Winzeler, EA; Eribez, K; Mittal, N; Gamo, FJ; Crespo, B; Churchyard, A; Garcia-Barbazan, I; Baum, J; Anderson, MO; Laleu, B; Guy, RK or send Email.. SDS of cas: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. Recently I am researching about ANTI-HIV ACTIVITY; CARBONYL-COMPOUNDS; EFFICIENT SYNTHESIS; CHEMOSELECTIVE ACETALIZATION; MONTMORILLONITE CLAY; ANTIFUNGAL ACTIVITY; IONIC LIQUID; KETONES; ALDEHYDES; ACETALS, Saw an article supported by the Tunis El-Manar University. Published in SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK in ANKARA ,Authors: Hagui, W; Essid, R; Amri, S; Feris, N; Khabbouchi, M; Tabbene, O; Limam, F; Srasra, E; Besbes, N. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A new heterogeneous acid catalyst based on a natural resource, Tunisian clay (Clay-H0.5), has been prepared and characterized by FT-IR, FE-SEM, and powder X-ray diffraction (XRD), as well as chemical composition, cation exchange capacity, specific surface area, and pore volume. Acid treatment for 0.5 h enlarged the surface area from 78.24 to 186.10 m(2)/g and pore volume (PV) from 0.186 to 0.281 cm(3)/g. The catalytic activity of this material was investigated in ketalization reaction under mild solvent-free conditions. This achieved up to 92% isolated yield for only 10 wt.% of the catalyst. This environmentally friendly method has advantages such as simple work-up procedure, avoidance of organic solvents, and good performance in ketalization reactions. Importantly, the Clay-H0.5 catalyst showed good recyclability where insignificant activity loss was exhibited even after six runs. Synthesized cyclic ketals were tested for their possible antileishmanial and antibacterial activities as well as antifungal activity. Biological screening showed that compound 11 had important antileishmanial activity against both L. major and L. infantum, while compound 14 also had significant antibacterial activity against four gram-positive and two gram-negative bacteria, and antifungal activity against Candida albicans, with minimal inhibitory concentration values ranging from 15.62 mu g/mL to 125 mu g/mL.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Hagui, W; Essid, R; Amri, S; Feris, N; Khabbouchi, M; Tabbene, O; Limam, F; Srasra, E; Besbes, N or concate me.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Li, MJ; Zheng, ZB; Zhang, ZG; Li, NW; Liu, SW; Chi, ZG; Xu, JR; Zhang, Y in MDPI published article about in [Li, Maijun; Zheng, Zhibo; Liu, Siwei; Chi, Zhenguo; Xu, Jiarui; Zhang, Yi] Sun Yat Sen Univ, Guangdong Engn Technol Res Ctr High Performance O, State Key Lab Optoelect Mat & Technol, PCFM Lab,GD HPPC Lab,Sch Chem, Guangzhou 510275, Peoples R China; [Zhang, Zhiguang; Li, Nanwen] Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taiyuan 030001, Peoples R China in 2021.0, Cited 64.0. Recommanded Product: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

To improve the interfacial compatibility of mixed matrix membranes (MMMs) for gas separation, microporous polyimide particle (AP) was designed, synthesized, and introduced into intrinsic microporous polyimide matrix (6FDA-Durene) to form all polyimide MMMs. The AP fillers showed the feature of thermal stability, similar density with polyimide matrix, high porosity, high fractional free volume, large microporous dimension, and interpenetrating network architecture. As expected, the excellent interfacial compatibility between 6FDA-Durene and AP without obvious agglomeration even at a high AP loading of 10 wt.% was observed. As a result, the CO2 permeability coefficient of MMM with AP loading as low as 5 wt.% reaches up to 1291.13 Barrer, which is 2.58 times that of the pristine 6FDA-Durene membrane without the significant sacrificing of ideal selectivity of CO2/CH4. The improvement of permeability properties is much better than that of the previously reported MMMs, where high filler content is required to achieve a high permeability increase but usually leads to significant agglomeration or phase separation of fillers. It is believed that the excellent interfacial compatibility between the PI fillers and the PI matrix induce the effective utilization of porosity and free volume of AP fillers during gas transport. Thus, a higher diffusion coefficient of MMMs has been observed than that of the pristine PI membrane. Furthermore, the rigid polyimide fillers also result in the excellent anti-plasticization ability for CO2. The MMMs with a 10 wt.% AP loading shows a CO2 plasticization pressure of 300 psi.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Li, MJ; Zheng, ZB; Zhang, ZG; Li, NW; Liu, SW; Chi, ZG; Xu, JR; Zhang, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2021.0 CATAL COMMUN published article about PHASE SELECTIVE OXIDATION; METAL-ORGANIC FRAMEWORK; 1 ATM; N-HYDROXYPHTHALIMIDE; CATALYTIC-OXIDATION; ACETOPHENONE; SYSTEM; ALKYLAROMATICS; COMPLEX; KETONES in [Dai, Xuan; Li, Xingyan; Tang, Shuangling; Peng, Xinhua] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China; [Zheng, Xuegen; Jiang, Ou] Sinopec Anqing Petrochem Co, Anqing 246000, Peoples R China in 2021.0, Cited 35.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

The simply prepared CuMgAl hydrotalcite (CuMgAl-LDH) has been developed as an efficient catalyst for the aerobic oxidation of ethylbenzene to acetophenone in the presence of N-Hydroxyphthalimide (NHPI). Various alkyl arenes could be tolerated under the selected reaction conditions. The kinetic study showed that the oxidation of ethylbenzene is a first-order reaction over CuMgAl-LDH. The mechanism study indicated that CuMgAl-LDH could accelerate not only the conversion of ethylbenzene, but also the transformation of the alcohol intermediate to ketone. The positive effect of surface basicity of the catalyst on the reaction has been observed in the aerobic oxidation of the ethylbenzene.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

HPLC of Formula: C8H7NO3. I found the field of Science & Technology – Other Topics; Materials Science very interesting. Saw the article Self-Assembled Magnetic Pt Nanocomposites for the Catalytic Reduction of Nitrophenol published in 2019.0, Reprint Addresses Liu, J (corresponding author), Hunan Univ Arts & Sci, Coll Chem & Mat Engn, Changde 415000, Peoples R China.; Liu, J; Zhang, HB (corresponding author), Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.; Zhang, HB (corresponding author), Wuhan Univ, Natl Demonstrat Ctr Expt Chem, Wuhan 430072, Hubei, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Self-assembled nanotechnology has been used widely in various well-defined microstructures fabrication. Herein, this synthetic protocol was successfully utilized to in situ or hierarchically prepare magnetic Pt nanocomposites Fe3O4@Pt via a distinguishing two-step process. The distinction of these two pathways is due to the different synthetic processes. In the case of in situ preparation (Path I), it involves a supramolecular self-assembly of boron clusters with gamma-CD on Fe3O4 substrate and then followed by in situ formation of Pt nanoparticles (NPs). But in the case of hierarchical preparation (Path II), the first step is preparing Pt NPs colloids reduced by boron clusters Cs-2[closo-B12H12], and subsequent step is immobilizing the as-prepared [closo-B12H12](2-)-capped Pt NPs on the Fe3O4@gamma-CD. The success of these two fabrication strategies lies in the use of trifunctional boron clusters (reductant, stabilizer, and superchaotropic anchor). Both of the as-prepared Fe3O4@Pt nanocomposites showed good catalytic performance in the selective nitro-group reduction of nitroaromatics. A control test further indicated that the in situ prepared Fe3O4@Pt nanocomposites, with smaller size and higher loading of Pt NPs, exhibited a better catalytic performance and recyclability.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 SYNTHETIC COMMUN published article about ASYMMETRIC REDUCTION; CARBONYL REDUCTASE; DEHYDROGENASE; ACETOPHENONE; KETONES; CELLS in [Baydas, Yasemin; Dertli, Enes] Bayburt Univ, Fac Engn, Dept Food Engn, Bayburt, Turkey; [Sahin, Engin] Bayburt Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-6900 Bayburt, Turkey in 2020.0, Cited 31.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Biocatalytic reduction is a very important field of research in synthetic organic chemistry. Herein, three different Lactic Acid Bacteria (LAB) strains were evaluated for their bioreduction potential using acetophenone as a model substrate. Among these strains, Lactobacillus kefiri P2 strain was determined as the best asymmetric reduction biocatalyst. Reaction optimization parameters such as reaction time, temperature, agitation speed and pH were systematically optimized using Lactobacillus kefiri P2 strain and model substrate acetophenone. Under these optimized reaction conditions, secondary chiral alcohols were obtained by bioreduction of various prochiral ketones with results up to 99% enantiomeric excess. In addition, the steric and electronic effects of substituents on enantioselectivity and conversion were evaluated. It has been shown that Lactobacillus kefiri P2 biocatalyst was an effective catalyst for asymmetric reduction. This method provides an environmentally friendly method for the synthesis of optically pure alcohols and an alternative approach to chemical catalysts.

Welcome to talk about 100-19-6, If you have any questions, you can contact Baydas, Y; Dertli, E; Sahin, E or send Email.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Computed Properties of C8H7NO3. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation published in 2019.0, Reprint Addresses Khanye, SD (corresponding author), Rhodes Univ, Dept Chem, Fac Sci, ZA-6140 Grahamstown, South Africa.; Khanye, SD (corresponding author), Rhodes Univ, Ctr Chem & Biomed Res, ZA-6140 Grahamstown, South Africa.; Khanye, SD (corresponding author), Rhodes Univ, Fac Pharm, ZA-6140 Grahamstown, South Africa.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide-hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2-8 mu M without any cytotoxic effects. Compounds 10 (MIC90; 0.9 mu M), 11 (MIC90; 0.2 mu M), 12 (MIC90; 0.8 mu M) and compound 15 (MIC90; 0.8 mu M), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions -1 and -3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.

Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Beteck, RM; Seldon, R; Jordaan, A; Warner, DF; Hoppe, HC; Laming, D; Legoabe, LJ; Khanye, SD or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 2,2-Diphenylacetonitrile. Authors Lippa, RA; Battersby, DJ; Murphy, JA; Barrett, TN in AMER CHEMICAL SOC published article about in [Lippa, Rhys A.; Murphy, John A.] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland; [Battersby, David J.; Barrett, Tim N.] GlaxoSmithKline, Med Sci & Technol, Stevenage SG1 2NY, Herts, England in 2021, Cited 51. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C(sp(3))-C(sp(3)) coupling between (chloromethyl)aryls and air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation and was followed by millimolar-scale reaction parameter optimization. A range of structurally and electronically varied arylethylamine products were obtained in moderate to excellent yields (27-96%, >60 examples). The reaction mechanism is proposed to proceed via formation of a trialkylbenzylammonium species prior to oxidative addition.

Quality Control of 2,2-Diphenylacetonitrile. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Lippa, RA; Battersby, DJ; Murphy, JA; Barrett, TN or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article I-2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process published in 2019. Safety of 2,2-Diphenylacetonitrile, Reprint Addresses Zhang, XH; Xiong, Y (corresponding author), Chongqing Univ, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China.; Xiong, Y (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China.. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

One-step base promoted strategy for cyanation of alpha,alpha-diaryl alcohols has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of beta,gamma-unsaturated nitriles and alpha-phenylnitiriles from alpha-vinyl carbinols and alpha,alpha-diaryl methanols, respectively, up to 99% yield. Moreover, various azides and ethers could also be accessed from their respective nucleophiles under standard reaction conditions. (C) 2018 Elsevier Ltd. All rights reserved.

Safety of 2,2-Diphenylacetonitrile. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Hu, LZ; Hussain, MI; Deng, QF; Liu, Q; Feng, YY; Zhang, XH; Xiong, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Computed Properties of C8H7NO3. In 2019.0 CHEM RES TOXICOL published article about MIXED-LIGAND COMPLEXES; DNA INTERACTION; ANTICANCER ACTIVITY; ZINC(II) COMPLEXES; MOLECULAR DOCKING; GROWTH-INHIBITION; CANCER-CELLS; COPPER(II); NICKEL(II); BINDING in [Bharathi, Sundaram; Mahendiran, Dharmasivam; Rahiman, Aziz Kahlur] Univ Madras, New Coll Autonomous, Postgrad & Res Dept Chem, Chennai 600014, Tamil Nadu, India; [Mahendiran, Dharmasivam] Univ Sydney, Bosch Inst, Dept Pathol, Mol Pharmacol & Pathol Program, Sydney, NSW 2006, Australia; [Kumar, Raju Senthil] Swamy Vivekanandha Coll Pharm, Dept Pharmaceut Chem, Elayampalayam 637205, Tiruchengodu, India; [Kim, Young Guk; Gajendiran, Mani; Kim, Kyobum] Incheon Natl Univ, Sch Life Sci & Bioengn, Div Bioengn, Incheon 22012, South Korea in 2019.0, Cited 48.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Eight heteroleptic nickel(II) and copper(II) complexes of the type [M(L1-4)(nap)(2)] (1-8), where L1-4 = 2-(1-(4-substitutedphenyl)ethylidene)-hydrazinecarbothioamide, nap = naproxen, and M = Ni(II) or Cu(II), have been synthesized and characterized. UV-vis and EPR spectral studies showed distorted octahedral geometry around metal(II) ions. The cyclic voltammogram of complexes 1-8 displayed an irreversible one-electron transfer process in the cathodic region (E-pc = -0.66 to -1.43 V), and nickel(II) complexes 1-4 displayed an irreversible one-electron oxidation process in the anodic region (E-pa = 0.75 to 1.10 V). The obtained magnetic moment values (1.82-1.93 mu(B)) for copper(II) complexes 5-8 indicate distortion from octahedral geometry, which is further supported by EPR studies. The geometry of the complexes is retained in both solid and solution phases as evidenced from UV-vis and EPR studies. All the complexes showed stability for almost 72 h in biologically relevant solutions. The reducing ability of the copper(II) complexes in the presence of ascorbic acid was analyzed by UV-vis and cyclic voltammetry techniques, which indicates the reduction of the copper(II) to a copper(I) center, and possible interaction within the cells. An in vitro antiproliferative study revealed the nontoxic nature of complexes to normal human dermal fibroblast (NHDF) up to a concentration of 100 ng/mL. The antiproliferative activity of the complexes was tested against three cancerous (human breast adenocarcinoma (MCF-7), hepatoma (HepG2), and lung (A549)) cell lines using MTT reduction assay, which showed enhanced activity for complexes 4 and 8 containing the hydrophobic substituent. Apoptotic and cellular uptake studies showed that complex 8 is readily taken up by HepG2 cell lines and induces ROS-mediated mitochondrial and caspase-dependent apoptosis. In silico studies indicated hydrogen bonding, hydrophobic, and pi-pair (pi-pi, pi-sigma, and pi-cation) interactions between the complexes and EGFR/VEGFR2 kinase receptors.

Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Bharathi, S; Mahendiran, D; Kumar, RS; Kim, YG; Gajendiran, M; Kim, K; Rahiman, AK or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem