Day: January 4, 2022

Category: benzodioxans. Xiao, FH; Yuan, SS; Huang, HW; Zhang, F; Deng, GJ in [Xiao, Fuhong; Yuan, Shanshan; Huang, Huawen; Deng, Guo-Jun] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Key Lab Green Organ Synth & Applicat, Xiangtan 411105, Peoples R China; [Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China published Copper-Catalyzed Three-Component Domino Cyclization for the Synthesis of 4-Aryl-5-(arythio)-2-(trifluoromethyl)oxazoles in 2019.0, Cited 59.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A copper-catalyzed oxidative cyclization of oxime, arylthiol, and trifluoroacetic anhydride for the construction of trisubstituted oxazoles has been developed. This transformation combines N-O bond cleavage, C-H functionalization, and intramolecular annulation, providing a practical protocol for the introduction of a trifluoromethyl (-CF3) group at oxazole rings.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Xiao, FH; Yuan, SS; Huang, HW; Zhang, F; Deng, GJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling published in 2020.0. Computed Properties of C8H7NO3, Reprint Addresses Cho, KJ (corresponding author), Wright State Univ, Dept Biochem & Mol Biol, Dayton, OH 45435 USA.; Ketcha, DM (corresponding author), Wright State Univ, Dept Chem, Dayton, OH 45435 USA.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Ras proteins are small GTPases which regulate cellular proliferation, differentiation, and apoptosis. Constitutively active mutant Ras are expressed in similar to 15-20% human cancers, and K-Ras mutations account for similar to 85% of all Ras mutations. Despite the significance of Ras proteins in refractory cancers, there is no anti-Ras drug available in clinic. Since K-Ras must interact with the plasma membrane (PM) for biological activity, inhibition of the K-Ras/PM interaction is a tractable approach to block oncogenic K-Ras activity. Here, we discovered chalcones 1 and 8 exhibit anti-K-Ras activity, and show that the compounds mislocalize K-Ras from the PM and block oncogenic K-Ras signal output. Also, 1 inhibits the growth of K-Ras-driven human cancer cells. Our data suggest that 1 could be a promising starting point for developing anti-K-Ras cancer drug.

Welcome to talk about 100-19-6, If you have any questions, you can contact Kovar, SE; Fourman, C; Kinstedt, C; Williams, B; Morris, C; Cho, KJ; Ketcha, DM or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. In 2020.0 TETRAHEDRON LETT published article about COUNTERION in [Lai, Jia-Wei; Liu, Zhao-Yang; Chen, Xiao-Yan; Zhang, Hao; Liu, Hai-Yang] South China Univ Technol, Dept Chem, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China in 2020.0, Cited 36.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Cobalt(III) corrole was firstly applied to the hydration of terminal alkynes. The alkyne hydration proceeded in good to excellent yield with 0.03 to 0.3 mol% cobalt corrole catalyst loading. A wide range of substrates were tolerated. Particularly, the reaction can give 90% yield in a gram scale experiment. (C) 2020 Elsevier Ltd. All rights reserved.

SDS of cas: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Biswas, S; Manna, CK; Naskar, R; Das, A; Mondal, TK in [Biswas, Sujan; Manna, Chandan Kumar; Naskar, Rahul; Das, Akash; Mondal, Tapan Kumar] Jadavpur Univ, Inorgan Chem Sect, Dept Chem, Kolkata 700032, India published Synthesis of new rhodium(III) complex by benzylic C-S bond cleavage of thioether containing NNS donor Schiff base ligand: Investigation of catalytic activity towards transfer hydrogenation of ketones in 2021.0, Cited 59.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A new rhodium(III)-triphenylphosphine mixed ligand complex, [Rh(PPh3)(L)Cl-2] (1) is synthesized by benzylic C-S bond cleavage of L-CH2Ph ligand (where, L-CH2Ph = 2-(benzylthio)-N-(pyridin-2-ylmethylene)aniline). The complex is thoroughly characterized by several spectroscopic techniques. Geometry of the complex is confirmed by single crystal X-ray crystallography. Electronic structure, redox properties, absorption and emission properties of the complex were studied. DFT and TDDFT calculations were carried out to interpret the electronic structure and absorption properties of the complex respectively. The synthesized Rh(III) complex was tested as catalyst towards transfer hydrogenation reaction of ketones in iPrOH and an excellent catalytic conversion was observed under mild conditions.

Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Biswas, S; Manna, CK; Naskar, R; Das, A; Mondal, TK or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Authors Zaini, MF; Razak, IA; Khairul, WM; Arshad, S in INT UNION CRYSTALLOGRAPHY published article about in [Zaini, Muhamad Fikri; Razak, Ibrahim Abdul; Arshad, Suhana] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, Usm 11800, Penang, Malaysia; [Khairul, Wan Mohd] Univ Malaysia Terengganu, Sch Fundamental Sci, Terengganu 21030, Malaysia in 2020.0, Cited 23.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new conjugated carbazole chalcone compound, (E)-3[4-(9,9a-dihydro-8aH-carbazol-9-yl)phenyl]-1-(4-nitrophenyl)prop-2-en-1-one (CPNC), C27H18N2O3, was synthesized using a Claisen Schmidt condensation reaction. CPNC crystallizes in the monoclinic non-centrosymmetric space group Cc and adopts an s-cis conformation with respect to the ethylenic double bonds (C=O and C=C). The crystal packing features C-H center dot center dot center dot O and C-H center dot center dot center dot pi interactions whose percentage contribution was quantified by Hirshfeld surface analysis. Quantum chemistry calculations including geometrical optimization and molecular electrostatic potential (MEP) were analysed by density functional theory (DFT) with a B3LYP/6-311 G++(d,p) basis set.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Sadjadi, S; Lazzara, G; Heravi, MM; Cavallaro, G in ELSEVIER published article about SULFONIC-ACID GROUPS; HETEROGENEOUS CATALYST; GREEN SYNTHESIS; NITROBENZENE HYDROGENATION; PALLADIUM NANOPARTICLES; EFFICIENT CATALYST; SEPARABLE CATALYST; CLAY NANOTUBES; HECK; NANOCOMPOSITES in [Sadjadi, Samahe] Iran Polymer & Petrochem Inst, Fac Petrochem, Gas Convers Dept, POB 14975-112, Tehran, Iran; [Lazzara, Giuseppe; Cavallaro, Giuseppe] Univ Palermo, Dipartimento Fis & Chim, Viale Sci,Pad 17, I-90128 Palermo, Italy; [Heravi, Majid M.] Alzahra Univ, Sch Sci, Dept Chem, POB 1993891176, Tehran, Iran; [Cavallaro, Giuseppe] Consorzio Interuniv Nazl Sci & Tecnol Mat, INSTM, Via G Giusti 9, I-50121 Florence, Italy in 2019.0, Cited 78.0. Category: benzodioxans. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

In this article, a magnetic carbon-coated halloysite nanoclay (Hal) was prepared through introduction of hydrothermally carbonized glucose (Glu) on Hal followed by the immobilization of magnetic nanoparticles (MNPs) and incorporation of resorcinol-formaldehyde polymeric shell (RF) and carbonization. The resulting composite was then successfully applied for the immobilization of Pd nanoparticles to afford Pd@Hal@Glu-Fe-C that could efficiently promote hydrogenation of nitroarenes in the aqueous media at low temperature. The catalyst exhibited high selectivity toward nitro group. Moreover, it was highly recyclable with low MNPs and Pd leaching. To elucidate the contribution of each component of the support to the catalysis, a precise study was carried out by preparing several control catalysts and comparing their catalytic activities with that of Pd@Hal@Glu-Fe-C. Furthermore, the effect of carbon source used for the formation of hydrothermally derived carbon -wrapped Hal and the order of incorporation of metallic nanoparticles on the catalytic activity of the final catalyst was investigated.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about ANTIMYCOBACTERIAL ACTIVITY; POLYPEPTIDE DEFORMYLASE; PHARMACOKINETICS; GSK1322322; SAFETY; TARGET; ACIDS, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Gokhale, KM; Telvekar, VN. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Product Details of 100-19-6

Emergence of MDR-TB and XDR-TB led to the failure of available anti-tubercular drugs. In order to explore, identify and develop new anti-tubercular drugs, novel peptidomimetic series of Mtb-peptide deformylase (PDF) inhibitors was designed and synthesized. In vitro antimycobacterial potential of compounds was established by screening of compounds againstMycobacterium tuberculosisH37Rv strain using MABA. Among them, ester series of compounds4a,4b,4c,4d, and4ewere found most active, with compound4cbeing highly active and exhibiting minimum inhibitory concentration of 6.25 mu g/ml againstM. tbH37Rv strain. Additionally, the compounds were docked to determine the probable binding interactions and understand the mechanism of action of most active molecules on Mtb-peptide deformylase (PDF), which is involved in the mycobacterium protein synthesis.

Product Details of 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Zhou, YL; Xu, XJ; Sun, HW; Tao, GY; Chang, XY; Xing, XY; Chen, B; Xu, C in NATURE RESEARCH published article about in [Zhou, Yali; Xu, Xingjun; Sun, Hongwei; Tao, Guanyu; Chang, Xiao-Yong; Xing, Xiangyou; Xu, Chen] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen, Guangdong, Peoples R China; [Zhou, Yali; Xu, Xingjun; Sun, Hongwei; Tao, Guanyu; Chang, Xiao-Yong; Xing, Xiangyou; Xu, Chen] Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen, Guangdong, Peoples R China; [Chen, Bo] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen, Guangdong, Peoples R China in 2021, Cited 66. Recommanded Product: 2,2-Diphenylacetonitrile. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

Hydrofunctionalization, the direct addition of an X-H (e.g., X=O, N) bond across an alkene, is a desirable strategy to make heterocycles that are important structural components of naturally occurring molecules. Described here is the design and discovery of donor-acceptor-type platinum catalysts that are highly effective in both hydroalkoxylation and hydroamination of unactivated alkenes over a broad range of substrates under mild conditions. A number of alkene substitution patterns are accommodated, including tri-substituted, 1,1-disubstituted, (E)-disubstituted, (Z)-disubstituted and even mono-substituted double bonds. Detailed mechanistic investigations suggest a plausible pathway that includes an unexpected dissociation/re-association of the electron-deficient ligand to form an alkene-bound donor-acceptor-type intermediate. These mechanistic studies help understand the origins of the high reactivity exhibited by the catalytic system, and provide a foundation for the rational design of chiral catalysts towards asymmetric hydrofunctionalization reactions. The direct addition of an O-H (hydroalkoxylation) or an N-H (hydroamination) bond across an alkene is a useful strategy to access biologically relevant heterocycles. Here, the authors report donor-acceptor-type platinum catalysts that are effective for both hydroalkoxylation and hydroamination of unactivated alkenes, with broad substrate scope and use of mild conditions.

Bye, fridends, I hope you can learn more about C14H11N, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 2,2-Diphenylacetonitrile

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019 BIOORG CHEM published article about NUCLEAR RIBONUCLEOPROTEIN-K; CARBON NANOTUBES BINDING; I-MOTIF DNA; CELL-PROLIFERATION; STRANDED-DNA; G-QUADRUPLEX; PROMOTER; PROTEIN; METASTASIS; MECHANISM in [Shu, Bing; Zeng, Ping; Kang, Shuangshuang; Li, Peng-Hui; Hu, Dexuan; Kuang, Guotao; Cao, Jiaojiao; Li, Xiaoya; Zhang, Meiling; An, Lin-Kun; Huang, Zhi-Shu; Li, Ding] Sun Yat Sen Univ, Sch Pharmaceut Sci, 132 Waihuan East Rd, Guangzhou 510006, Guangdong, Peoples R China; [Shu, Bing] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China in 2019, Cited 54. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Product Details of 100-19-6

Aberrant overexpression of heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key feature in oncogenesis and progression of many human cancers. hnRNP K has been found to be a transcriptional activator to up-regulate c-myc gene transcription, a critical proto-oncogene for regulation of cell growth and differentiation. Therefore, down-regulation of c-myc transcription by inhibiting hnRNP K through disrupting its binding to c-myc gene promoter is a potential approach for cancer therapy. In the present study, we synthesized and screened a series of Quinoline derivatives and evaluated their binding affinity for hnRNP K. Among these derivatives, (E)-1-(4-methoxyphenyl)-3-(4 morpholino-6-nitroquinolin-2-yl)prop-2-en-1-one (compound 25) was determined to be the first-reported hnRNP K binding ligand with its K-D values of 4.6 and 2.6 mu M measured with SPR and MST, respectively. Subsequent evaluation showed that the binding of compound 25 to hnRNP K could disrupt its unfolding of c-myc promoter i-motif, resulting in down-regulation of c-myc transcription. Compound 25 showed a selective anti-proliferative effect on human cancer cell lines with IC50, values ranged from 1.36 to 3.59 mu M. Compound 25 exhibited good tumor growth inhibition in a Hela xenograft tumor model, which might be related to its binding with hnRNP K. These findings illustrated that inhibition of DNA-binding protein hnRNP K by compound 25 could be a new and selective strategy of regulating oncogene transcription instead of targeting promoter DNA secondary structures such as G-quadruplexes or i-motifs.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. Authors Vasilyeva, TP; Vorobyeva, DV in SPRINGER published article about in [Vasilyeva, T. P.; Vorobyeva, D. V.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Ul Vavilova, Moscow 119991, Russia in 2021.0, Cited 28.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

New 1,5-diaryl-3-(pyridin-4 ‘-yl)pentane-1,5-diones were synthesized via the tandem reaction of pyridin-4-carbaldehyde with methyl (aryl) ketones in the presence of sodium hydride. The treatment of the diketones with ammonium acetate resulted in heterocyclization to 2,6-diaryl-4-(pyridin-4 ‘-yl)pyridines.

Welcome to talk about 100-19-6, If you have any questions, you can contact Vasilyeva, TP; Vorobyeva, DV or send Email.. Quality Control of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem