Day: December 22, 2021

Recently I am researching about TARGETING TUBULIN; DISCOVERY; ANALOGS; AFFINITY; SERIES, Saw an article supported by the Mashhad university of medical sciences. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Oskuei, SR; Mirzaei, S; Jafari-Nik, MR; Hadizadeh, F; Eisvand, F; Mosaffa, F; Ghodsi, R. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Novel imidazole-chalcone derivatives were designed and synthesized as tubulin polymerization inhibitors and anticancer agents. The antiproliferative activity of the imidazole-chalcone was assessed on some human cancer cell lines including A549 (adenocarcinoma human alveolar basal epithelial cells), MCF-7 (human breast cancer cells), MCF-7/MX (mitoxantrone resistant human breast cancer cells), and HEPG2 (human hepatocellular carcinoma cells). Generally, the imidazole-chalcone derivatives exhibited more cytotoxicity on A549 cancer cells in comparison to the other three cell lines, among them compounds 9j’ and 9g showed significant cytotoxicity with IC50 values ranging from 7.05 to 63.43 mu M against all the four human cancer cells. The flow cytometry analysis of A549 cancer cells treated with 9g and 9j’ displayed that these compounds induced cell cycle arrest at the G2/M phase at low concentrations and increased the number of apoptotic cells (cells in subG1 phase) at higher concentrations. They have also inhibited tubulin polymerization similar to combretastatin A-4 (CA-4). Annexin V binding staining assay in A549 cancer cells revealed that compound 9j’ induced apoptosis (early and late). Finally, molecular docking studies of 9j’ into the colchicine-binding site of tubulin presented the probable interactions of these compounds with tubulin.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about N-TOSYLHYDRAZONES; ENANTIOSELECTIVE SYNTHESIS; SULFONYL HYDRAZONES; SIMPLE OLEFINS; BOND-CLEAVAGE; CONSTRUCTION; HETEROCYCLES; DERIVATIVES; ROUTE; ISOCYANIDES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21901124]; Jiangsu University Natural Science Research Program [19KJB150032, 19KJB610013]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M651809]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Feng, JJ; He, TT; Xie, YX; Yu, Y; Baell, JB; Huang, F. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Computed Properties of C8H7NO3

A facile and efficient strategy for the synthesis of 1,4-dihydropyridazines and pyridazines through I-2-promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones has been developed. The switch in selectivity is attributed to the judicious choice of different reaction temperatures. The key features of this work include controllable and selective synthesis, good functional group tolerance, good to excellent reaction yields, metal/base-free conditions, and also applicability to one-pot methodology.

Welcome to talk about 100-19-6, If you have any questions, you can contact Feng, JJ; He, TT; Xie, YX; Yu, Y; Baell, JB; Huang, F or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Liu, CJ; Mei, M; Zang, LM; Zhou, HF; Huang, XH; Wei, C in [Liu, Chanjuan; Mei, Mei; Zang, Limin; Zhou, Huanfu; Huang, Xiaohua; Wei, Chun] Guilin Univ Technol, Collaborat Innovat Ctr Explorat Hidden Nonferrous, Key Lab New Proc Technol Nonferrous Met & Mat, Minist Educ,Sch Mat Sci & Engn, Guilin 541004, Peoples R China published Highly Thermally Stable, Organosoluble, and Hydrophobic Polyimides with Pyrrolidinylphenyl Pendant Groups and Pyridine Units in 2019.0, Cited 37.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A novel diamine monomer, 4-{4-(1-pyrrolidinyl)phenyl}-2,6-bis(4-aminophenyl) pyridine (PPAP), was synthesized using 4-(1-pyrrolidinyl)benzaldehyde as starting material, and a series of aromatic polyimides were prepared using PPAP and five aromatic dianhydrides by a two-step imidization method. The structure and properties of as-prepared polyimides were studied by Fourier transform infrared spectrometer (FTIR), nuclear magnetic resonance (NMR), thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and wide angle X-ray diffraction (WAXD). The results indicated that these polymers had good solubility in highboiling organic solvents upon heating, such as N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and N-methyl-2-pyrrolidone (NMP). Furthermore, they had outstanding thermal properties with the glass transition temperature (T-g) exceeding 354 degrees C, as well as T-5% and T-10% mass loss temperature under a nitrogen atmosphere in the range of 521534 oC and 544594 oC, respectively. Moreover, they exhibited excellent hydrophobic properties with the contact angles ranging from 82.7 to 90.5 degrees. In addition, the results of WAXD showed that these polyimides exhibited the structure of amorphous polymers.

Recommanded Product: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. I found the field of Chemistry very interesting. Saw the article Transfer Hydrogenation of Ketones and Imines with Methanol under Base-Free Conditions Catalyzed by an Anionic Metal-Ligand Bifunctional Iridium Catalyst published in 2020.0, Reprint Addresses Li, F (corresponding author), Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

An anionic iridium complex [Cp*Ir(2,2′-bpyO)(OH)][Na] was found to be a general and highly efficient catalyst for transfer hydrogenation of ketones and imines with methanol under base-free conditions. Readily reducible or labile substituents, such as nitro, cyano, and ester groups, were tolerated under present reaction conditions. Notably, this study exhibits the unique potential of anionic metal-ligand bifunctional iridium catalysts for transfer hydrogenation with methanol as a hydrogen source.

Welcome to talk about 100-19-6, If you have any questions, you can contact Wang, RZ; Han, XY; Xu, J; Liu, P; Li, F or send Email.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Transition Metal Oxide-Modified Ir Nanoparticles Supported on SBA-15 Silica for Selective Hydrogenation of Substituted Nitroaromatics WOS:000677582900072 published article about CHEMOSELECTIVE HYDROGENATION; CATALYTIC-SYSTEM; CARBON; FE; NITROBENZENE; EFFICIENCY; OXIDATION; ANILINE; SIZE; THIN in [Wu, Chunzheng] Zhejiang A&F Univ, Coll Sci, Hangzhou 311300, Zhejiang, Peoples R China; [Yu, Hongbo; Wang, Shiwei; Li, Tong; Yin, Hongfeng] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China in 2021.0, Cited 46.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Modification of active metals with metal oxide modifiers has attracted considerable attention in heterogeneous catalysis due to their synergistic effect. However, a controllable synthesis of highly reactive and stable metal-metal oxide hybrid nanocatalysts is difficult. To solve this problem, presynthesized IrM (M = Fe, Co, and Ni) bimetallic nanoparticles were initially confined in the mesopores of SBA-15 and were then in situ transformed to Ir-MOx hybrids. The obtained Ir-MOx/SBA-15 nanocatalysts show superior activity and selectivity in the hydrogenation of substituted nitroaromatics to corresponding aromatic amines compared to Ir/SBA-15. Among these Ir-based catalysts, Ir-FeOx/SBA-15 exhibits the highest activity and selectivity and has a wider substrate scope due to the interaction between Ir and FeOx. Therefore, our research provides a way to design reactive and stable hydrogenation catalysts.

Welcome to talk about 100-19-6, If you have any questions, you can contact Yu, HB; Wu, CZ; Wang, SW; Li, T; Yin, HF or send Email.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry; Materials Science; Metallurgy & Metallurgical Engineering very interesting. Saw the article Ni-Au alloy nanoparticles as a high performance heterogeneous catalyst for hydrogenation of aromatic nitro compounds published in 2019.0. Safety of 1-(4-Nitrophenyl)ethanone, Reprint Addresses Lang, LM (corresponding author), Nanjing Xiaozhuang Univ, Lab Adv Funct Mat Nanjing, Nanjing 211171, Jiangsu, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Selective hydrogenation of nitro compounds requires highly active and less expensive materials as a heterogeneous catalyst. As a good candidate, the Ni-Au alloy nanoparticles (NPs) have been synthesized by simple in-situ reduction method, which was loaded to the active carbon with 10 wt % loading amount. The Ni-Au/C catalyst shows superior catalytic performance for hydrogenation of nitro compounds with 100% conversion and selectivity without any by-products, which also indicates good recycle performance for several times use. The prepared catalyst not only reduces the usage amount of noble metal, but also keeps the high catalytic activity, which is a promising catalyst for industry applications. (C) 2019 Elsevier B.V. All rights reserved.

Safety of 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Lang, LM; Pan, ZR; Yan, J or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases WOS:000475378400004 published article about ALKALINE-PHOSPHATASE; BIOLOGICAL EVALUATION; PHOSPHODIESTERASE-I; DERIVATIVES; PROTEIN; IDENTIFICATION; AGENTS; CALCIFICATION; LOCALIZATION; THIAZOLES in [Andleeb, Hina; Hameed, Shahid; Khan, Imtiaz] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Andleeb, Hina] Int Islamic Univ, Fac Basic & Appl Sci, Sulaiman Bin Abdullah Aba Al Khail Ctr Interdisci, Islamabad, Pakistan; [Ejaz, Syeda Abida; Zaib, Sumera; Iqbal, Jamshed] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad 22060, Pakistan; [Khan, Imtiaz] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England; [Khan, Imtiaz] Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England; [Lecka, Joanna; Sevigny, Jean] Univ Laval, Fac Med, Dept Microbiol Infectiol & Immunol, Quebec City, PQ G1V 0A6, Canada; [Lecka, Joanna; Sevigny, Jean] Univ Laval, CHU Quebec, Ctr Rech, Quebec City, PQ G1V 4G2, Canada in 2019.0, Cited 52.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

With the aim to discover novel, efficient and selective inhibitors of human alkaline phosphatase and nucleotide pyrophosphatase enzymes, two new series of pyrazolyl pyrimidinetriones (PPTs) (6a-g) and thioxopyrimidinediones (PTPs) (6h-n) were synthesized in good chemical yields using Knoevenagel condensation reaction between pyrazole carbaldehydes (4a-g) and pharmacologically active N-alkylated pyrimidinetrione (5a) and thioxopyrimidinedione (5b). The inhibition potential of the synthesized hybrid compounds was evaluated against human alkaline phosphatase (h-TNAP and h-IAP) and ectonucleotidase (h-NPP1 and h-NPP3) enzymes. Most of the tested analogs were highly potent with a variable degree of inhibition depending on the functionalized hybrid structure. The detailed structure-activity relationship (SAR) of PPT and PTP derivatives suggested that the compound with unsubstituted phenyl ring from PPT series led to selective and potent inhibition (6a; IC50= 0.33 +/- 0.02 mu M) of h-TNAP, whereas compound 6c selectively inhibited h-IAP isozyme with IC50 value of 0.86 +/- 0.04 mu M. Similarly, compounds 6b and 6h were identified as the lead scaffolds against h-NPP1 and h-NPP3, respectively. The probable binding modes for the most potent inhibitors were elucidated through molecular docking analysis. Structure-activity relationships, mechanism of action, cytotoxic effects and druglikeness properties are also discussed.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Andleeb, H; Hameed, S; Ejaz, SA; Khan, I; Zaib, S; Lecka, J; Sevigny, J; Iqbal, J or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Niu, PF; Liu, X; Shen, ZL; Li, MC in MDPI published article about SELECTIVE AEROBIC OXIDATION; ELECTRON-TRANSFER KINETICS; HIGHLY EFFICIENT; BENZYL ALCOHOL; ELECTROCATALYTIC ACTIVITY; TEMPO; ALDEHYDES; CATALYST; ELECTROOXIDATION; NITRILES in [Niu, Pengfei; Liu, Xin; Shen, Zhenlu; Li, Meichao] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Zhejiang, Peoples R China; [Niu, Pengfei; Liu, Xin; Li, Meichao] Zhejiang Univ Technol, Res Ctr Anal & Measurement, Hangzhou 310032, Zhejiang, Peoples R China in 2019.0, Cited 72.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The ketones was successfully prepared from secondary alcohols using 9-azabicyclo[3.3.1]nonane-N-oxyl (ABNO) as the catalyst and 2,6-lutidine as the base in acetonitrile solution. The electrochemical activity of ABNO for oxidation of 1-phenylethanol was investigated by cyclic voltammetry, in situ Fourier transform infrared spectroscopy (FTIR) and constant current electrolysis experiments. The resulting cyclic voltammetry indicated that ABNO exhibited much higher electrochemical activity when compared with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) under the similar conditions. A reasonable reaction mechanism of the electrocatalytic oxidation of 1-phenylethanol to acetophenone was proposed. In addition, a series of secondary alcohols could be converted to the corresponding ketones at room temperature in 80-95% isolated yields.

Product Details of 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 MOL DIVERS published article about ORGANIC-REACTIONS; REGIOSELECTIVE SYNTHESIS; DOMINO REACTION; AQUEOUS-MEDIA; CONSTRUCTION; CHEMISTRY; CATALYST; DESIGN; ACCESS; INDOLE in [Anary-Abbasinejada, Mohammad; Nezhad-Shshrokhabadi, Frershteh; Mohammadi, Marziyeh] Vali E Asr Univ, Dept Chem, Rafsanjan 77176, Iran in 2020.0, Cited 58.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Product Details of 100-19-6

Three-component reaction between arylglyoxals, 1,3-dicetones and enaminoketones leads to new polyfunctionalized tetraone derivatives which may be easily converted to polyfunctionalized pyrroles. Reactions were conducted in water or water-ethanol mixture as green solvents, and all products were isolated by simple washing of the resulting solids with diethyl ether.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Borinic Acid Mediated Hydrosilylations: Reductions of Carbonyl Derivatives WOS:000458273900012 published article about HYDROSILATION; KETONES; SILYLATION; ALDEHYDES; NITRILES; IMINES; AMINES in [Chardon, Aurelien; Rouden, Jacques; Blanchet, Jerome] Normandie Univ, ENSICAEN, UNICAEN, CNRS,LCMT, F-14000 Caen, France in 2019.0, Cited 40.0. Category: benzodioxans. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

4-Fluoro-2-chlorophenylborinic acid acts as a precatalyst in the presence of phenylsilane for the facile reduction of ketones, aldehydes and imines. Notably, synergistic mediation of a tertiary amine was found essential to trigger silicon to boron hydride transfer to generate a key amine-diarylhydroborane Lewis complex.

Category: benzodioxans. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem