Day: December 8, 2021

Category: benzodioxans. Recently I am researching about METAL-ORGANIC FRAMEWORKS; HETEROGENEOUS CATALYST; BRONSTED ACIDITY; BENZOXAZOLES; EFFICIENT; ZR; CHEMISTRY; SCAFFOLD; CASCADE, Saw an article supported by the Vietnam National University, Ho Chi Minh City [NCM2019-50-01]. Published in ELSEVIER in AMSTERDAM ,Authors: Nguyen, LHT; Nguyen, TTT; Dang, MHD; Tran, PH; Doan, TLH. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Use of green chemistry and alternative strategies has been explored to prepare diverse organic derivatives. The combination between heterogeneous catalyst, environmentally benign reaction and high-yielding methods is gaining momentum. Herein, a defective 6-connected Hf-MOF, named Hf-BTC, was efficiently synthesized and characterized for the heterogeneous catalysis under microwave irradiation. The MOF features including structural defect, porosity, acidity, and stability was analyzed by powder X-ray diffraction, N-2 sorption isotherms, acid-base titration, and thermal gravimetric analysis. In the catalytic studies, the Brunsted-Lewis dual acidic HfBTC was efficiently applied for the synthesis of the heterocyclic compounds via the microwave-assisted cycloaddition and condensation reactions. The reactions proceeded smoothly in the presence of the Hf-MOF with a broad scope of substrates provided the expected products in high to excellent yields (up to 99 %) for few minutes and the catalyst could be easily recycle over many consecutive reactions without loss of its reactivity and structure.

Category: benzodioxans. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Computed Properties of C8H7NO3. Recently I am researching about REDUCED GRAPHENE OXIDE; WALLED CARBON NANOTUBES; SUZUKI-MIYAURA; PALLADIUM NANOPARTICLES; SELECTIVE HYDROGENATION; HIERARCHICAL NANOSTRUCTURES; HETEROGENEOUS CATALYST; IMMOBILIZED PALLADIUM; IONIC LIQUID; EFFICIENT, Saw an article supported by the National Research Foundation (NRF) of South AfricaNational Research Foundation – South Africa; University of KwaZulu-Natal (UKZN). Published in SPRINGER INTERNATIONAL PUBLISHING AG in CHAM ,Authors: Labulo, AH; Omondi, B; Nyamori, VO. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

This work focused on the synthesis of 3D Pd-based nanocomposites which were tested in Heck coupling reactions and for the hydrogenation of nitroarenes. This was achieved by fabrication of graphene oxide/nitrogen-doped carbon nanotubes (G/N-CNTs) by mechanical grinding of 2D graphene oxide (GO) and 1D oxygen-treated nitrogen-doped CNTs (N-CNTs-OT) in a 3:1 ratio, respectively. The fabrication of G/N-CNTs is to overcome the habitual aggregation and restacking of graphene sheets. Palladium nanoparticles (Pd NPs) were deposited on the 3D G/N-CNTs nanocomposites via metal organic chemical vapour deposition method. The 3D Pd-based nanocomposites were characterized by TEM, SEM, HRTEM, XRD, TGA, XPS, ICP-OES, elemental analysis, BET analysis and Raman spectroscopy. For the Heck coupling reactions, aryl halides, olefins and 3D Pd-based nanocomposites were mixed in a suitable solvent and the reaction carried under microwave irradiation.The chemoselective hydrogenation of nitroarenes was done with dry ethanol in a Paar reactor, purged with H-2 gas. These catalysts demonstrate excellent activity and selectivity in both reactions. The remarkable activity of the 3D Pd-based nanocomposites in Heck reactions and hydrogenation of nitroarenes may be attributed to the small particle size (3-10 nm) and a high degree of dispersion of Pd NPs. A comparative experiment was conducted with Pd/AC, Pd/CNTs, Pd/G/CNTs and Pd/rGO. Pd/G/N-CNTs-OT showed higher activity and selectivity than Pd/G/CNTs, Pd/G/N-CNTs, Pd/rGO and Pd/N-CNTs counterpart.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Safety of 1-(4-Nitrophenyl)ethanone. I found the field of Chemistry very interesting. Saw the article Organocatalytic Reduction of Nitroarenes with Phenyl(2-quinolyl)methanol published in 2020, Reprint Addresses Giomi, D; Brandi, A (corresponding author), Univ Firenze, Dipartimento Chim Ugo Schiff, Via Lastruccia 3-13, I-50019 Sesto Fiorentino, FI, Italy.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

The transition metal free reduction of aromatic/heteroaromatic nitro compounds to amines has been improved employing phenyl(2-quinolyl)methanol (PQM) as organocatalyst in the presence of NaBH(4)or NaCNBH(3)as stoichiometric reducing agent. The procedure is chemoselective for NO(2)group reduction with high tolerance of many functionalities. The reaction pathway strongly depends on the substituents present on the nitroarene ring. However, a careful choice of the reaction conditions allows to address the reduction process towards the corresponding anilines (isolated in 17-91 % yields). The use of substoichiometric amounts of PQM allows more sustainable processes: reaction products are easily isolated and PQM can be directly recovered at the end of the reaction and recycled.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Giomi, D; Ceccarelli, J; Salvini, A; Brandi, A or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Yamali, C; Gul, HI; Ece, A; Bua, S; Angeli, A; Sakagami, H; Sahin, E; Supuran, CT in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about CARBONIC-ANHYDRASE-IX; SQUAMOUS-CELL CARCINOMA; STRUCTURE-CYTOTOXICITY RELATIONSHIP; TYROSINE KINASE INHIBITOR; PHENOLIC MANNICH-BASES; CYCLOOXYGENASE-2 INHIBITOR; RHEUMATOID-ARTHRITIS; ISOFORMS IX; SULFONAMIDES; APOPTOSIS in [Yamali, Cem; Gul, Halise Inci] Ataturk Univ, Fac Pharm, Dept Pharmaceut Chem, TR-25240 Erzurum, Turkey; [Ece, Abdulilah] Biruni Univ, Fac Pharm, Dept Pharmaceut Chem, Istanbul, Turkey; [Bua, Silvia; Angeli, Andrea; Supuran, Claudiu T.] Univ Firenze, Neurofarba Dept, Sez Sci Farmaceut & Nutraceut, Via U Schiff 6, I-50019 Florence, Italy; [Sakagami, Hiroshi] Meikai Univ, Res Inst Odontol M RIO, Sakado, Saitama 3500283, Japan; [Sahin, Ertan] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey in 2019.0, Cited 84.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Inhibition of carbonic anhydrases (CAs, EC 4.2.1.1) has clinical importance for the treatment of several diseases. They participate in crucial regulatory mechanisms for balancing intracellular and extracellular pH of the cells. Among CA isoforms, selective inhibition of hCA IX has been linked to decreasing of cell growth for both primary tumors and metastases. The discovery of novel CA inhibitors as anticancer drug candidates is a current topic in medicinal chemistry. 1,3,5-Trisubstituted pyrazoles carrying benzenesulfonamide were evaluated against physiologically abundant cytosolic hCA I and hCA II and trans-membrane, tumor-associated hCA IX isoforms by a stopped-flow CO2 hydrase method. Their in vitro cytotoxicities were screened against human oral squamous cell carcinoma (OSCC) cell lines (HSC-2) and human mesenchymal normal oral cells (HGF) via 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) test. Compounds 6, 8, 9, 11, and 12 showed low nanomolar hCA II inhibitory potency with Ki < 10 nM, whereas compounds 9 and 12 displayed Ki < 10 nM against hCA IX isoenzyme when compared with reference Acetazolamide (AZA). Compound 9, 4-(3-(hydrazinecarbonyl) 5 (4 nitropheny1)-1H-pyrazol-1-yebenzenesulfonamide, can be considered as the most selective hCA IX inhibitor over off-target cytosolic isoenzymes hCA I and hCA II with the lowest Ki value of 2.3 nM and selectivity ratios of 3217 (hCA I/hCA IX) and 3.9 (hCA II/hCA IX). Isoform selectivity profiles were also discussed using in silico modelling. Cytotoxicity results pointed out that compounds 5 (CC50, = 37.7 mu M) and 11 (CC50 = 58.1 mu M) can be considered as lead cytotoxic compounds since they were more cytotoxic than 5-Fluorouracil (5-FU) and Methotrexate (MTX). Welcome to talk about 100-19-6, If you have any questions, you can contact Yamali, C; Gul, HI; Ece, A; Bua, S; Angeli, A; Sakagami, H; Sahin, E; Supuran, CT or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Chemoselective Hydrogenation of Functionalized Nitroarenes into Anilines by Supported Molybdenum Catalysts published in 2020.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone, Reprint Addresses Xiao, LP; Chen, XH (corresponding author), Dalian Polytech Univ, Ctr Lignocellulos Chem & Biomat, 1 Qinggongyuan, Dalian 116034, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Anilines are the most important fine chemicals that have been widely used as the intermediates of industrial products. Herein, a new series of nanostructured Mo-based catalysts were reported, such as MoOx/ZSM-5(25), MoOx/ZSM-5(50) and MoOx/SBA-15, which can serve as efficient catalysts in the hydrogenation of nitroarenes by using hydrogen as the reducing reagent to afford functionalized anilines. Those catalysts showed both excellent activity and high chemoselectivity of the nitro group even though other reducible groups (C-X, C=C, C=O and C equivalent to N) were exiting. This protocol constitutes an economically responsible pathway for the synthesis of anilines in high yields, good functional group compatibility and high chemselectivity.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Yan, SS; Guo, YZ; Xiao, LP; Chen, XH; Sun, RC or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 ACS OMEGA published article about SCHIFF-BASE COMPLEX; EFFICIENT HETEROGENEOUS CATALYST; METAL BASED CATALYSTS; N-HYDROXYPHTHALIMIDE; CRYSTAL-STRUCTURE; TIO2 NANOPARTICLES; BENZYLIC ALCOHOLS; HYDRAZONE LIGAND; ETHYL BENZENE; MOLYBDENUM in [Tavallaei, Hasan; Jafarpour, Maasoumeh; Feizpour, Fahimeh; Rezaeifard, Abdolreza; Farrokhi, Alireza] Univ Birjand, Dept Chem, Catalysis Res Lab, Fac Sci, Birjand 97179414, Iran in 2019.0, Cited 77.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Computed Properties of C8H7NO3

In this study, a new heterobimetallic Mo(VI)-V(V) organosilicon Schiff base complex has been prepared and characterized by different techniques, such as FTIR, Raman, MS, ICP-AES, TGA, and XPS. The bimetallic nanocomplex, revealed by TEM images, showed high oxidation stability and desired activity in the aerobic oxidation of a structurally diverse set of benzylic alcohols in ethanol as a safe solvent. Further, oxidation of benzylic hydrocarbons successfully occurred, producing the target compounds in high yields and excellent selectivities. Our results demonstrated a cooperative effect between Mo(VI) and V(V) as redox active sites in an organosilicon Schiff base framework. A facile and practical reusability of the solid catalyst at the end of the reaction was observed.

Welcome to talk about 100-19-6, If you have any questions, you can contact Tavallaei, H; Jafarpour, M; Feizpour, F; Rezaeifard, A; Farrokhi, A or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Synthesis and Anticancer Activity of N-(di/trimethoxyaryl)-5-arylisoxazole-3-carboxamide WOS:000583587600026 published article about BIOLOGICAL EVALUATION; CYTOTOXIC ACTIVITY; IN-VITRO; ISOXAZOLE; INHIBITION; APOPTOSIS; CURCUMIN; GROWTH in [Saeedi, Mina] Univ Tehran Med Sci, Fac Pharm, Med Plants Res Ctr, Tehran, Iran; [Saeedi, Mina; Karimpour-Razkenari, Elahe; Akbarzadeh, Tahmineh] Univ Tehran Med Sci, Persian Med & Pharm Res Ctr, Tehran, Iran; [Hashemi, Mehdi; Rafinejad, Ali; Akbarzadeh, Tahmineh] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran; [Mahdavi, Mohammad] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran; [Najafi, Zahra] Hamadan Univ Med Sci, Sch Pharm, Dept Med Chem, Hamadan, Hamadan, Iran; [Mirfazli, Seyedeh Sara] Iran Univ Med Sci, Sch Pharm, Dept Med Chem, Int Campus, Tehran, Iran; [Mohammadian, Razieh; Kabudanian Ardestani, Sussan] Univ Tehran, Inst Biochem & Biophys, Dept Biochem, Tehran, Iran; [Safavi, Maliheh] Iranian Res Org Sci & Technol, Dept Biotechnol, Tehran, Iran in 2020.0, Cited 30.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

In this study, a new series of N-(di or trimethoxyaryl)-5-arylisoxazole-3-carboxamide derivatives were synthesized and evaluated against human breast cancer cell lines including MCF-7, MDA-MB-231, and T-47D. Among the synthesized compounds, 5-(m-tolyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide (8f) showed significant cytotoxicity against all three cell lines comparing with etoposide as the reference drug. Also, Annexin V-FITC/propidium iodide and acridine orange/ethidium bromide staining assay were performed to validate apoptotic activity of compound 8f. The results confirmed induction of apoptosis at early stage.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Saeedi, M; Hashemi, M; Mahdavi, M; Rafinejad, A; Najafi, Z; Mirfazli, SS; Mohammadian, R; Karimpour-Razkenari, E; Ardestani, SK; Safavi, M; Akbarzadeh, T or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Dermatology very interesting. Saw the article Metformin is associated with decreased risk of basal cell carcinoma: A whole-population case-control study from Iceland published in 2021.0. Name: 1-(4-Nitrophenyl)ethanone, Reprint Addresses Adalsteinsson, JA (corresponding author), Univ Connecticut, Dept Dermatol, 21 South Rd, Farmington, CT 06030 USA.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Background: Metformin has anticarcinogenic properties and is also known to inhibit the sonic hedgehog pathway, but population-based studies analyzing the potential protective effect for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are needed. Objectives: To delineate the association between metformin use and invasive SCC, SCC in situ (SCCis), and BCC. Methods: A population-based case-control study design was employed using all 6880 patients diagnosed in Iceland between 2003-2017 with first-time BCC, SCCis, or invasive SCC, and 69,620 population controls. Multivariate odds ratios (ORs) were calculated using conditional logistic regression. Results: Metformin was associated with a lower risk of developing BCC (OR, 0.71; 95% confidence interval [CI], 0.61-0.83), even at low doses. No increased risk of developing SCC was observed. SCCis risk was mildly elevated in the 501-1500 daily dose unit category (OR, 1.40; 95% CI, 1.00-1.96). Limitations: This study was retrospective in nature with the inability to adjust for ultraviolet exposure, Fitzpatrick skin type, and comorbidities. Conclusion: Metformin is associated with decreased risk of BCC development, even at low doses. Metformin might have potential as a chemoprotective agent for patients at high risk of BCC, although this will need confirmation in future studies.

Name: 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. I found the field of Chemistry very interesting. Saw the article Theoretical and computational insight into the supramolecular assemblies of Schiff bases involving hydrogen bonding and C-H center dot center dot center dot pi interactions: Synthesis, X-ray characterization, Hirshfeld surface analysis, anticancer activity and molecular docking analysis published in 2021.0, Reprint Addresses Andleeb, H; Hameed, S (corresponding author), Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan.; Andleeb, H (corresponding author), Int Islamic Univ, Fac Basic & Appl Sci, Sulaiman Bin Abdullah Aba Al Khail Ctr Interdisci, Islamabad, Pakistan.; Khan, I (corresponding author), Univ Manchester, Dept Chem, 131 Princess St, Manchester M1 7DN, Lancs, England.; Khan, I (corresponding author), Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England.; Simpson, J (corresponding author), Univ Otago, Dept Chem, POB 56, Dunedin 9054, New Zealand.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

The present study examines the significance of various non-covalent interactions in the supramolecular assembly of (E)-1-(1-(4-nitrophenyl)ethylidene)-2-phenylhydrazine 1c and (E)-3-bromo-N’-(1-phenylethylidene)benzohydrazide 2d. The synthesized compounds were fully characterized by spectroscopic methods and single crystal X-ray diffraction analysis. The topology of the supramolecular assemblies was controlled by various non-covalent interactions including classical hydrogen bonding, C-H center dot center dot center dot pi and Br center dot center dot center dot Br interactions which were examined in detail using several theoretical methods and DFT calculations. The optimized geometric parameters of compounds 1c and 2d were calculated using density functional theory (DFT/B3LYP) quantum chemical method with the 6-311++G(d,p) basis set using the crystallographic coordinates. Additionally, fragments contributing to the HOMO and LUMO molecular orbitals were investigated at the same level of theory. The nature and various types of intermolecular interactions in the crystal structures was also investigated by Hirshfeld surface analysis. The synthesized Schiff bases were also studied for their potential as drugs and physicochemical properties. Bioevaluation against four cancer cell lines (NCI-H460, NCI-H460/Bcl-2, MDA-MB-231 and MCF-7) showed that compound 1c was a more potent inducer of toxicity compared to 2d. The putative binding modes of the bioactive Schiff bases were investigated using molecular docking tools and the results revealed that both the inhibitors were stabilized in the active pocket of the enzyme via the formation of various interactions with the key amino acid residues. (C) 2021 Elsevier B.V. All rights reserved.

Recommanded Product: 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Andleeb, H; Danish, L; Munawar, S; Ahmed, MN; Khan, I; Ali, HS; Tahir, MN; Simpson, J; Hameed, S or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Na2S-promoted reduction of azides in water: synthesis of pyrazolopyridines in one pot and evaluation of antimicrobial activity WOS:000465614900012 published article about BIOLOGICAL EVALUATION; PRIMARY AMINES; EFFICIENT; DERIVATIVES; REAGENT; INHIBITORS; CONVERSION; DISCOVERY; DESIGN; ACID in [Kale, Ashok; Medishetti, Nagaraju; Atmakur, Krishnaiah] Indian Inst Chem Technol, CSIR, Fluoro & Agro Chem Dept, Hyderabad 500007, Telangana, India; [Kanugala, Sirisha; Kumar, Ganesh C.] Indian Inst Chem Technol, CSIR, Med Chem & Pharmacol Div, Hyderabad 500007, Telangana, India; [Kale, Ashok; Medishetti, Nagaraju; Kanugala, Sirisha; Atmakur, Krishnaiah] Indian Inst Chem Technol, AcSIR, Hyderabad 500007, Telangana, India in 2019.0, Cited 48.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reduction of various azides using Na2S has been accomplished in water, and, in situ, the resulting amines on reaction with various ketones lead to pyrazolo[3,4-b]pyridines in one pot. Thus, a number of new trifluoromethyl-substituted pyrazolo[3,4-b]pyridine compounds have been prepared and screened for antimicrobial activity against different Gram-positive and Gram-negative strains. A good number of compounds, 4a, 4b, 4d, 4f, 4i, 4k, 4l, 4m, 4r and 4s, were found to possess promising activity. Notably, Na2S on hydrolysis in water generates H2S and NaOH, which facilitate the reduction of azides followed by intramolecular cyclization leading to the title compounds. To the best of our knowledge, this is the first report of the synthesis of the title compounds in aqueous medium in a one-pot reaction.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem