Authors Babu, LS; Shaik, AB; Prasad, YR in INT JOURNAL LIFESCIENCE & PHARMA RESEARCH published article about in [Babu, Lagu Surendra; Prasad, Y. Rajendra] Andhra Univ, Dept Pharmaceut Chem, AU Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India; [Shaik, Afzal Basha] Vignan Pharm Coll, Guntur 522213, Andhra Pradesh, India in 2019.0, Cited 16.0. COA of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
Infectious diseases are one of the common problems encountered globally. Even though there are a number of drugs available in the market for the treatment of infectious diseases, still many new molecules are required due to the problems with the existing drugs. Hence we prepared a series of chalcones (Al-A10) containing nitrophenyl moieties by Claisen-Schmidt condensation reaction. All the ten compounds were characterized by IR, NMR, Mass spectroscopy and elemental analysis. The compounds were further screened for antitubercular activity employing MABA assay and antibacterial and antifungal activities by cup plate method against selected tubercular, bacterial and fungal organisms. The compound A9 displayed potent antitubercular activity with MIC 11.02 +/- 0.030, whereas the compound A3 showed superior antibacterial and antifungal activities. Further, molecular docking studies were performed on Thymidine Kinase (TMP) of Mycobacterium tuberculosis by employing AU autodocker. The docking scores were in association with the in vitro MABA results and also identified the potent nature of A9 with the docking score -6.7. This study helped to identify novel nitrophenyl derivatives against thymidylate kinase.
COA of Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Babu, LS; Shaik, AB; Prasad, YR or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem