Day: October 26, 2021

Authors Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Rana, Manish; Arif, Rizwan; Yasmeen, Shama; Dar, Sajad Hussain; Rahisuddin] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Khan, Faez Iqbal] Univ Elect Sci & Technol China, Sch Elect Sci & Engn, Chengdu, Peoples R China; [Maurya, Vikas; Singh, Raja] Jawharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India; [Faizan, Md Imam; Ahmad, Tanveer] Jamia Millia Islamia, Multidisciplinary Ctr Adv Res & Studies, New Delhi 110025, India; [Alam, Raquib] Jamia Millia Islamia, Univ Polytech, Dept Appl Sci, New Delhi 110025, India; [Sahu, Ankita] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi 110029, India in 2021.0, Cited 77.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

N-formyl pyrazoline derivatives (3a-3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carried out by various spectroscopic techniques such as H-1, C-13 NMR, FT-IR, UV-visible spectroscopy, mass spectrometry and elemental analysis. Anticancer activity of the pyrazoline derivatives (3a-3l) was evaluated against human lung cancer (A549), fibrosarcoma cell lines (HT1080) and human primary normal lung cells (HFL-1) by MTT assay. The results of anticancer activity showed that potent analogs 3b and 3d exhibited promising activity against A549 (IC50 = 12.47 +/- 1.08 and 14.46 +/- 2.76 mu M) and HT1080 (IC50 = 11.40 +/- 0.66 and 23.74 +/- 13.30 mu M) but low toxic against the HFL-1 (IC50 =116.47 +/- 43.38 and 152.36 +/- 22.18 mu M). The anticancer activity of potent derivatives (3b and 3d) against A549 cancer cell line was further confirmed by flow cytometry based approach. DNA binding interactions of the pyrazoline derivatives 3b and 3d have been carried out with calf thymus DNA (Ct-DNA) using absorption, fluorescence and viscosity measurements, circular dichroism and cyclic voltammetry. Antioxidant potential of N-formyl pyrazoline derivatives (3a-3l) has been also estimated through DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical and H2O2. Results revealed that all the compounds exhibited significant antioxidant activity. In silico molecular modelling and ADMET properties of pyrazoline derivatives were also studied using PyRx software against topoisomerase II receptor with PDB ID: 1ZXM to explore their best hits. MD simulation of 3b and 3d was also carried out with topoisomerase II for structure-function correlation in a protein. HuTopoII inhibitory activity of the analogs (3a-3l) was examined by relaxation assay at varying concentrations 100-1000 mu M.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 BIOORG CHEM published article about PROLIFERATOR-ACTIVATED RECEPTORS; CYCLOOXYGENASE-2 INHIBITORS; MOLECULAR DOCKING; INFLAMMATION; GLUCOSIDASE; REGULATOR; DISCOVERY; ANALOGS; RAT in [Abdellatif, Khaled R. A.; Fadaly, Wael A. A.] Beni Suef Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Bani Suwayf, Egypt; [Abdellatif, Khaled R. A.] Ibn Sina Natl Coll Med Studies, Pharmaceut Sci Dept, Jeddah 21418, Saudi Arabia; [Kamel, Gehan M.] Cairo Univ, Fac Vet, Pharmacol Dept, Cairo, Egypt; [Elshaier, Yaseen A. M. M.] Al Azhar Univ, Pharmaceut Organ Chem Dept, Fac Pharm, Assiut 71524, Egypt; [El-Magd, Mohammed A.] Kafrelshiekh Univ, Anat Dept, Fac Vet Med, Kafrelshiekh 33516, Egypt in 2019.0, Cited 51.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Formula: C8H7NO3

Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions as anti-inflammatory (AI) and anti-diabetic have been led to a temptation for focusing on the discovery and development of new compounds with potential AI and antidiabetic activities. Herein, we synthesized two new series containing pyrazole ring with vicinal diaryl rings as selective COX-2 moiety and thiazolidindione (series 12a-f) or thiazolidinone (series 13a-f) as anti-diabetic moiety and the two moieties were linked together with methylene or methylenehydrazone functionality. The two series were evaluated for their COX inhibition, AI activity and ulcerogenic liability and for the anti-diabetic activity; 12a-f and 13a-f were assessed in vitro against alpha-glucosidase, beta-glucosidase, in vivo hypoglycemic activity (one day and 15 days studies) in addition to PPAR. activation study. Four compounds (12c, 12f, 13b and 13f) had higher COX-2 S.I. (8.69-9.26) than the COX-2 selective drug celecoxib (COX-2 S.I. = 8.60) and showed the highest AI activities and the lowest ulcerogenicity than other derivatives. Also, two thiazolidindione derivatives 12e and 12f and two thiazolidinone derivatives 13b and 13c showed higher inhibitory activities against alpha- and beta-glucosidase (% inhibitory activity = 62.15, 55.30, 65.37, 59.08 for alpha-glucosidase and 57.42, 60.07, 58.19, 66.90 for beta-glucosidase respectively) than reference compounds (acarbose with % inhibitory activity = 49.50 for alpha-glucosidase and D-saccharic acid 1,4-lactone monohydrate with % inhibitory activity = 53.42 for beta-glucosidase) and also showed good PPAR-gamma activation and good hypoglycemic effect in comparison to pioglitazone and rosiglitazone. Moreover, Shape comparison and docking studies were carried out to understand their interaction and similarity with standard drugs.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Abdellatif, KRA; Fadaly, WAA; Kamel, GM; Elshaier, YAMM; El-Magd, MA or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. Authors Wang, YZ; Huang, XL; Wang, Q; Tang, YH; Xu, SL; Li, Y in AMER CHEMICAL SOC published article about in [Wang, Yongzhuang; Huang, Xiaoli; Wang, Qin; Tang, Yuhai; Xu, Silong; Li, Yang] Xi An Jiao Tong Univ, Dept Mat Chem, Sch Chem, Xian 710049, Peoples R China; [Wang, Yongzhuang; Huang, Xiaoli; Wang, Qin; Tang, Yuhai; Xu, Silong; Li, Yang] Xi An Jiao Tong Univ, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China in 2021.0, Cited 61.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

An efficient Cp*Rh-III-catalyzed formal C(sp(3))-H activation/spiroannulation of alkylidene Meldrum’s acids with alkynes has been developed using catalytical Cu(OAc)(2) and air as the oxidant. This reaction demonstrates a new and straightforward approach to spirocyclopentadienes with Meldrum’s acid moieties in good to excellent yields under mild reaction conditions with a broad substrate scope. Notably, this protocol provides a novel and straightforward approach to cyclopentadienes with various substitution patterns and the corresponding cyclopentadienyl-type ligands from simple substrates.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wang, YZ; Huang, XL; Wang, Q; Tang, YH; Xu, SL; Li, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020 FOOD RES INT published article about LOW-PRESSURE PLASMA; ACID in [Akasapu, Kumudhini; Gupta, Arun Kumar; Mishra, Poonam] Tezpur Univ, Dept Food Engn & Technol, Tezpur 784028, Assam, India; [Ojah, Namita; Choudhury, Arup Jyoti] Tezpur Univ, Dept Phys, Tezpur 784028, Assam, India in 2020, Cited 24. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. Quality Control of 2,2-Diphenylacetonitrile

In the present study, an innovative cold plasma treatment was used as a tool to fortify the white rice. The amounts of ferrous sulphate and ascorbic acid were optimized for improving the bioavailability of iron. White rice samples were treated with plasma at a constant voltage of 20 kV for varying time (10 min and 15 min). The exposure time of plasma was selected based on the surface characteristics, hydrophilicity and thermal properties. Significant improvement was observed in the characteristics of hydrophilicity, surface energy, cooking time and hardness of plasma-treated rice. Plasma treated rice was fortified with the optimum concentrations of iron and ascorbic acid solution. Optimum concentrations of iron and ascorbic acid per 100 g of rice (862.93 mg and 1398.27 mg) were found by conducing experiments using Central Composite Design of Response Surface Methodology. Further, rice was blended with untreated rice in the ratio of 1:100 and 1:200 and was packed in LDPE and PP pouches and was stored at ambient temperature for further storage analysis. The in vitro bioavailability of iron was significantly higher in the plasma-treated fortified rice at both 1.35 and 7.5 pH than in the control sample, and plasma treatment significantly reduced the rate of oxidation of iron during storage.

Quality Control of 2,2-Diphenylacetonitrile. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Akasapu, K; Ojah, N; Gupta, AK; Choudhury, AJ; Mishra, P or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C14H11N. Recently I am researching about PALLADIUM-CATALYZED CARBONYLATION; ARYL IODIDES; EXPEDITIOUS SYNTHESIS; AROMATIC SPIROKETALS; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; ALKYNYL KETONES; O-IODOPHENOLS; FORMIC-ACID; CHROMONES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472078, 21772079, 21572092]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Xiang, KR; Tong, P; Yan, BR; Long, LL; Zhao, CB; Zhang, Y; Li, Y. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

A one-pot Pd-catalyzed carbonylative Sonogashira coupling in tandem with double annulation reaction to synthesize benzannulated [6,6]-spiroketals from o-iodophenols and terminal alkynols or alkynyl phenols was achieved. The protocol provides straightforward and facile access to benzannulated [6,6]-spiroketals in moderate to good yields and excellent diastereoselectivities under balloon pressure of CO at room temperature.

Formula: C14H11N. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Xiang, KR; Tong, P; Yan, BR; Long, LL; Zhao, CB; Zhang, Y; Li, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Ultrasound-assisted diversion of nitrobenzene derivatives to their aniline equivalents through a heterogeneous magnetic Ag/Fe3O4-IT nanocomposite catalyst WOS:000594503300039 published article about NANOPARTICLES; NANOCATALYST; REDUCTION; EFFICIENT; PHOTOCATALYST; ALCOHOL; SYSTEM in [Taheri-Ledari, Reza; Rahimi, Jamal; Maleki, Ali] Iran Univ Sci & Technol IUST, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran; [Shalan, Ahmed Esmail] Cent Met Res & Dev Inst CMRDI, POB 87, Cairo 11421, Egypt; [Shalan, Ahmed Esmail] UPV EHU Sci Pk, BCMat, Basque Ctr Mat Applicat & Nanostruct, Barrio Sarriena S-N, Leioa 48940, Spain in 2020.0, Cited 48.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A heterogeneous magnetic catalytic system is fabricated and suitably applied for the fast and direct conversion of nitrobenzene (NB) derivatives to their aniline forms. For this purpose, different conditions and methods have been checked with numerous catalytic amounts of the nanocatalyst composite, which was constructed of iron oxide and silver nanoparticles and possessed an isothiazolone organic structure. Herein, the mechanistic aspect of the catalytic functioning of this highly efficient nanocatalyst is highlighted and discussed. Firstly, a convenient preparation route assisted by ultrasonication for this metal and metal oxide nanocomposite is presented. Further, a fast and direct reduction strategy for NBs is investigated using ultrasound irradiation (50 kHz, 200 W L-1). As two great advantages of this catalyst, high magnetic property and excellent reusability are also mentioned. This report well reveals that a really convenient conversion of NBs to anilines can be achieved with a high yield during the rapid reaction time in presence of mild reaction conditions.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Taheri-Ledari, R; Rahimi, J; Maleki, A; Shalan, AE or concate me.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about 2-(1H-PYRAZOL-1-YL)-THIAZOLE DERIVATIVES; APOPTOSIS; INHIBITORS; CYTOTOXICITY; OPTIMIZATION; ANTICANCER; GROWTH; SAR, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Reddy, NB; Zyryanov, GV; Reddy, GM; Balakrishna, A; Padmaja, A; Padmavathi, V; Reddy, CS; Garcia, JR; Sravya, G. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. HPLC of Formula: C8H7NO3

A new class of bis heterocycles-benzimidazolyl pyrazoles were prepared from the Michael acceptor (E)-3-(1H-benzimidazol-2-yl)-1-aryl-prop-2-en-1-one. The thiamide group was exploited to develop thiazole ring on treatment with p-fluorophenacyl bromide to get tris heterocycles. All the lead compounds were tested for antimicrobial activity. The compound 7d having nitro substituent on the aromatic ring showed greater antimicrobial activity particularly against Pseudomonas aeruginosa and Penicillium chrysogenum.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Reddy, NB; Zyryanov, GV; Reddy, GM; Balakrishna, A; Padmaja, A; Padmavathi, V; Reddy, CS; Garcia, JR; Sravya, G or concate me.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

COA of Formula: C14H11N. In 2019 ADV SYNTH CATAL published article about LIGHT PHOTOREDOX CATALYSIS; ALPHA-AMINOALKYL RADICALS; CENTERED RADICALS; RECENT PROGRESS; RATE CONSTANTS; GENERATION; FUNCTIONALIZATION; METHODOLOGY; CYCLIZATION; HYDRAZONYL in [Gao, Shuang; Niggeman, Meike] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany in 2019, Cited 56. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

N-Alkylanilines have rarely been used in oxyamination reactions, due to the normally necessary pre-functionalization of the N-atom. Also, the formation of aminium radical cations (ARCs) of anilines bearing alkyl substituents is plagued by the ARC’s tendency to instantaneously convert to alpha-amino radicals or iminium ions. We present a readily available reagent combination that addresses both challenges, and thus allows for an oxyamination with N-alkylanilines via ARCs as the crucial reactive intermediates and excellent diastereoselectivity.

COA of Formula: C14H11N. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Gao, S; Niggeman, M or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article A Lewis Base Supported Terminal Uranium Phosphinidene Metallocene published in 2020. Recommanded Product: 2,2-Diphenylacetonitrile, Reprint Addresses Zi, GF (corresponding author), Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China.; Walter, MD (corresponding author), Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, D-38106 Braunschweig, Germany.. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

A Lewis base supported terminal uranium phosphinidene, [eta(5)-1,3-(Me3C)(2)C5H3]2U(= P-2,4,6-(Bu3C6H2)-Bu-t)(OPMe3) (5), is isolated from the reaction of the uranium methyl chloride [eta(5)- 1,3-(Me3C)(2)C5H3](2)U(Cl) Me (4) with 2, 4, 6-(Me3C)(3)C6H2PHK in toluene in the presence of Me3PO. Moreover, the reactivity of uranium phospinidene 5 toward a series of small molecules was comprehensively explored. While no reactivity of 5 with internal alkynes is observed attributed to steric hindrance, it readily reacts in good yields with various small molecules including isothiocyanates, aldehydes, imines, diazenes, carbodiimides, nitriles, isonitriles, and organic azides, yielding uranium sulfidos, oxidos, metallaheterocycles, and imido complexes.

Recommanded Product: 2,2-Diphenylacetonitrile. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Wang, DQ; Wang, SC; Hou, GH; Zi, GF; Walter, MD or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Munyai, TR; Sonqishe, T; Gumbo, JR in [Munyai, Thabelo R.; Sonqishe, Thantaswa] Univ Venda, Dept Ecol & Resource Management, Thohoyandou, South Africa; [Gumbo, Jabulani R.] Univ Venda, Dept Hydrol & Water Resource Management, Thohoyandou, South Africa published Algae colonisation of brick pavement at the University of Venda: A potential slippery hazard in 2019, Cited 33. Category: benzodioxans. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

A brick pavement, tramped by humans, is exposed to atmospheric elements, thus allowing cyanobacteria and algae to colonise. In this article, we report on the factors that contribute to the slipperiness of a brick pavement at the University of Venda in the Limpopo province of the South Africa. Samples were collected from brick surfaces either colonised by green algae (treated) or not (control). The samples were acid-digested and analysed for metals by Inductively Coupled Plasma Mass Spectrometry (ICP MS) in parts per billion (ppb). The treated bricks, with green algae, had average high metal contents (ppb): Al 9456.02, Ti 731.23, V 46.44, Cr 78.85, Mn 862.93, Fe 16295.18, Co 23.57, Ni 59.36, Cu 66.31, Zn 160.57, As 7.92, Se 10.45, Mo 6.74, Cd 5.19, Sn 4.65, Sb 2.31 and Pb 19.51. In contrast, control bricks had a low average of metal content (ppb) as follows: Al 2.99, Ti 0.28, V 4.04, Cr 1.42, Mn 4.29, Fe 20.89, Co 0.36, Ni 2.74, Cu 5.64, Zn 4.21, As 0.56, Se <3.00, Mo 0.88, Cd 0.01, Sn 1.05, Sb 0.04 and Pb 0.04. Other factors that promote algae colonisation include high solar radiation, neutral pH, nutrients, low electrical conductivity and total dissolved solids. The algae colonisation of brick pavement results in an unaesthetic sighting and a slippery surface that is hazardous to humans. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Munyai, TR; Sonqishe, T; Gumbo, JR or concate me.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem