Day: October 25, 2021

In 2020 ORG BIOMOL CHEM published article about C-H; DIRECT ACYLOXYLATION; BENZOXYLATION; BONDS; ACTIVATION; ARYL; NOX in [Xiong, Xue; Mao, Yang-Jie; Hao, Hong-Yan; He, Yu-Ting; Xu, Zhen-Yuan; Lou, Shao-Jie; Xu, Dan-Qian] Zhejiang Univ Technol, Coll Chem Engn, Key Lab Green Pesticides & Cleaner Prod Technol Z, Catalyt Hydrogenat Res Ctr,State Key Lab Breeding, Hangzhou 310014, Peoples R China; [Luo, Gen] Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China in 2020, Cited 30. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Computed Properties of C8H7NO3

A nitrate-promoted Pd-catalysed mild cross-dehydrogenative C(sp(2))-H bond oxidation of oximes or azobenzenes with diverse carboxylic acids has been developed. In contrast to the previous catalytic systems, this protocol features mild conditions (close to room temperature for most cases) and a broad substrate scope (up to 64 examples), thus constituting a versatile method to directly prepare diverseO-aryl esters. Moreover, the superiority of the nitrate additive in this mild transformation was further determined by experimental and computational evidence.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Xiong, X; Mao, YJ; Hao, HY; He, YT; Xu, ZY; Luo, G; Lou, SJ; Xu, DQ or concate me.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Name: 1-(4-Nitrophenyl)ethanone. Authors Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y in ROYAL SOC CHEMISTRY published article about in [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, 189 Songling Rd, Qingdao 266101, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Crown St, Liverpool L69 7ZD, Merseyside, England; [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Shandong Energy Inst, Qingdao 266101, Peoples R China in 2021.0, Cited 66.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new methodology for the synthesis of alpha-diketones was reported via a one-pot cascade process from aldehydes and ketones catalyzed by a bifunctional iron nanocomposite using H2O2 as a green oxidant in water. The one-pot strategy showed excellent catalytic stability, comprehensive suitability of substrates and important practical utility for directly synthesizing biologically active and medicinally valuable N-heterocycles via an intermittent process.

Name: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about BISINDOLE, Saw an article supported by the Higher Education Commission, PakistanHigher Education Commission of Pakistan [59/PAS/3437]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Shaikh, NN; Iqbal, S; Syed, N; Khan, MA; Moin, ST; Choudhary, MI; Basha, FZ. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. COA of Formula: C8H7NO3

beta-Glucuronidase enzyme is a tetrameric glycoprotein present in microsomes and lysosomes of many organs, and body fluids. Over-expression of this enzyme is observed in several melanomas and carcinomas. Therefore, it has been identified as a target for the treatment of several pathological conditions. In this regard, carbazole linked 1,2,3-triazoles (1-27) were synthesized according to our previous report, and evaluated for their in vitro beta-glucuronidase inhibitory activities. Compounds 7-10, 17-18, 20, and 22-27 showed potent activities with IC50 values between 0.55-32.5 mu M, as compared to the standard, D-saccharic acid 1,4-lactone (IC50=45.75 +/- 2.16 mu M). All active compounds were found to be non-cytotoxic against mouse fibroblast 3T3 cell line. Compounds 20, 22, 23, 25, 26, and 27 were subjected to enzyme kinetic studies for the determination of their modes of inhibition, and dissociation constants Ki. Compounds 23, 25, and 26 were also studied for their mode of inhibition by using molecular docking methods.

COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Shaikh, NN; Iqbal, S; Syed, N; Khan, MA; Moin, ST; Choudhary, MI; Basha, FZ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Huang, X; Li, ZP; Liu, ZX; Zeng, CC; Hu, LM in [Huang, Xin; Li, Zhipeng; Liu, Zixin; Zeng, Chengchu; Hu, Liming] Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China published A near-infrared fluorescent probe for endogenous hydrogen peroxide real-time imaging in living cells and zebrafish in 2019.0, Cited 44.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Hydrogen peroxide (H2O2) can be produced in mitochondria and plays a significant role in physiological metabolism. Overproduction of H2O2 is a hallmark of many diseases. Therefore, it is very important to develop a highly sensitive method for detecting H2O2 both in vivo and in vitro. Previously reported benzil-based fluorescence probes are superior to those based on boronate ester in terms of reaction selectivity. However, the near infrared (NIR) probe with biocompatibility has been rarely reported for the detection of endogenous hydrogen peroxide and the real-time imaging in biological system. Hemicyanine skeleton has been proven to be effective scaffold for NM fluorescent probes for non-invasive optical imaging in vivo. In this paper, a Cy-H2O2 probe for real-time monitoring hydrogen peroxide in organisms was designed by modifying the NIR hemicyanine framework with benzil moiety. The results showed that Cy-H2O2 exhibits high specificity and sensitivity, and has good water solubility and short response time (within 10 min) for detection of hydrogen peroxide in vitro and in vivo. The reaction mechanism was deduced by detecting product of the fluorescent probe reacting with hydrogen peroxide using HPLC. The probe shows a good linear relationship for the specific response to H2O2 within the concentration range of 0-7 mu M and the detection limit is 65 nM. In addition, the probe Cy-H2O2 has been successfully applied to H2O2 detection in living cells and zebrafish.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Huang, X; Li, ZP; Liu, ZX; Zeng, CC; Hu, LM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about DIMETHYL-SULFOXIDE; FUNCTIONALIZATION; ALKYLATION; BOND; ALCOHOLS; HYDROGENATION; SULFONYLATION; HETEROARENES; HETEROCYCLES; OXIDATION, Saw an article supported by the Foundation of the Department of Education of Guangdong Province [2018KZDXM070, 2017KZDXM085, 2017KQNCX204]; Foundation for Young Talents [2018KQNCX272, 2018KQNCX273]; College Students Innovation and Entrepreneurship Training Program of Wuyi University; Climbing Program [pdjh2019b0497]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Jiang, SH; Yang, ZH; Guo, ZY; Li, YB; Chen, L; Zhu, ZZ; Chen, XW. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Recommanded Product: 100-19-6

A practical approach to the direct alpha-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Jiang, SH; Yang, ZH; Guo, ZY; Li, YB; Chen, L; Zhu, ZZ; Chen, XW or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 2,2-Diphenylacetonitrile. In 2021 CHEM-EUR J published article about CHEMISTRY; COMPLEXES in [Wang, Deqiang; Ding, Wanjian; Hou, Guohua; Zi, Guofu] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China; [Walter, Marc D.] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, Hagenring 30, D-38106 Braunschweig, Germany in 2021, Cited 121. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

The synthesis, electronic structure, and reactivity of a uranium metallacyclopropene were comprehensively studied. Addition of diphenylacetylene (PhC equivalent to CPh) to the uranium phosphinidene metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U=P-2,4,6-tBu(3)C(6)H(2) (1) yields the stable uranium metallacyclopropene, [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U[eta(2)-C2Ph2] (2). Based on density functional theory (DFT) results the 5f orbital contributions to the bonding within the metallacyclopropene U-(eta(2)-C=C) moiety increases significantly compared to the related Th-IV compound [eta(5)-1,2,4-(Me3C)(3)C5H2](2)Th[eta(2)-C2Ph2], which also results in more covalent bonds between the [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U2+ and [eta(2)-C2Ph2](2-) fragments. Although the thorium and uranium complexes are structurally closely related, different reaction patterns are therefore observed. For example, 2 reacts as a masked synthon for the low-valent uranium(II) metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U-II when reacted with Ph2E2 (E=S, Se), alkynes and a variety of hetero-unsaturated molecules such as imines, ketazine, bipy, nitriles, organic azides, and azo derivatives. In contrast, five-membered metallaheterocycles are accessible when 2 is treated with isothiocyanate, aldehydes, and ketones.

Recommanded Product: 2,2-Diphenylacetonitrile. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Wang, DQ; Ding, WJ; Hou, GH; Zi, GF; Walter, MD or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about 2 CHK2 INHIBITORS; POTENTIAL ANTICANCER; CARBAZOLES SYNTHESIS; DERIVATIVES; DISCOVERY; SCAFFOLD; BENDAMUSTINE; MOIETY; DRUGS, Saw an article supported by the Indian Council of Medical Research, New Delhi, IndiaIndian Council of Medical Research (ICMR) [58/16/2013BMS]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Sivaramakarthikeyan, R; Shunmugam, I; Vadivel, S; Lim, WM; Mai, CW; Ramalingan, C. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Recommanded Product: 100-19-6

Synthesis of a series of benzimidazole-ornamented pyrazoles, 6a-6j has been obtained from arylhydrazine and aralkyl ketones via a multistep synthetic strategy. Among them, a hybridpossessing para-nitrophenyl moiety connected to a pyrazole scaffold (6a) exerted the highest anti-inflammatory activity, which is superior to the standard, diclofenac sodium. While executing the 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, a hybrid-possessing para-bromophenyl unit integrated at the pyrazole structural motif (6i) exhibited the highest activity among the hybrids examined. Besides, evaluation of anticancer potency of the synthesized hybrids revealed that the one containing a para-fluorophenyl unit tethered at the pyrazole nucleus (6h) showed the highest activity against both the pancreatic cancer cells (SW1990 and AsPCl) investigated. Considerable binding affinity between B-cell lymphoma and the hybrid, 6h has been reflected while performing molecular docking studies (-8.65 kcal/mol). The outcomes of the investigation expose that these hybrids could be used as effective intermediates to construct more potent biological agents.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sivaramakarthikeyan, R; Shunmugam, I; Vadivel, S; Lim, WM; Mai, CW; Ramalingan, C or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Arif, R; Rana, M; Yasmeen, S; Amaduddin; Khan, MS; Abid, M; Khan, MS; Rahisuddin in [Arif, Rizwan; Rana, Manish; Yasmeen, Shama; Rahisuddin] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Amaduddin; Abid, Mohammad] Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India; [Khan, M. S.] Jamia Millia Islamia, Dept Phys, New Delhi 110025, India; [Khan, Md Shahzad] Galgotias Univ, Sch Basic & Appl Sci, Greater Noida 203201, India published Facile synthesis of chalcone derivatives as antibacterial agents: Synthesis, DNA binding, molecular docking, DFT and antioxidant studies in 2020.0, Cited 63.0. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A series of beta-chalcones derivatives (1a-11) was synthesized using different substituted amines in basic condition by Claisen-Schmidt condensation reaction. Structural analysis of the synthesized compounds was carried out by various characterization techniques. Antimicrobial properties of the chalcone derivatives (1a-11) were evaluated against different bacterial strains Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus pneumoniae and Enterococcus faecalis by disc diffusion method. The pharmacological treatment of chalcones showed that chalcone 1b has promising potential against tested bacterial strains. Ct-DNA was used to study the binding interactions of the potent chalcone derivative 1b by means of absorption spectroscopy, viscosity measurement, fluorescence quenching, cyclic voltammetery and circular dichroism study. Chalcone 1b showed significant binding towards Ct-DNA with intrinsic binding constant (K-b) 1.75 x 10(4)M(-1). Molecular docking study of the target compound was also carried out against B-DNA dodecamer d(CGCGAATTCGCG)(2) and it has been found that chalcone 1b can bind to Ct-DNA via an intercalative mode. For the chalcone derivative 1b and Ct-DNA interaction, static quenching mechanism observed which was further confirmed using time-resolved fluorescence spectroscopy. To optimize the chalcone derivative 1b for HOMO-LUMO energy calculation, Density Functional Theory (DFT) has been used. Time dependent-DFT study has been optimized to generate vertical excitation energies, absorption wavelengths and oscillator strengths of the chalcone derivative lb. Antioxidant activity was also carried out to evaluate the antioxidant nature of the chalcone derivative lb by DPPH and H2O2 assay. (C) 2020 Elsevier B.V. All rights reserved.

Name: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Arif, R; Rana, M; Yasmeen, S; Amaduddin; Khan, MS; Abid, M; Khan, MS; Rahisuddin or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Rastogi, GK; Deka, B; Deb, ML; Baruah, PK in [Rastogi, Gaurav K.; Deka, Bhaskar; Deb, Mohit L.; Baruah, Pranjal K.] Gauhati Univ, GUIST, Dept Appl Sci, Gauhati 781014, Assam, India; [Rastogi, Gaurav K.] NEIST, CSIR, Dept Appl Organ Chem, Jorhat 785006, Assam, India published Diastereoselective sp3-C-H Functionalization of Arylmethyl Ketones and Transformation of E- to Z-Products Through Photocatalysis in 2020.0, Cited 91.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

We have developed an efficient metal-free route for the synthesis of 1,4-enedione derivatives under microwave irradiation by reacting easily available arylmethylketones with DMSO or diphenyl sulfoxide in the presence of TBAI and persulfate. The reaction is very clean and completes within very short time. All the reagents and catalysts are cheap and environmentally benign. In addition, the E-isomer of the products can easily be transformed into the Z-isomer by using eosin Y photocatalyst under the irradiation of white CFL.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rastogi, GK; Deka, B; Deb, ML; Baruah, PK or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Efficient and Practical Transfer Hydrogenation of Ketones Catalyzed by a Simple Bidentate Mn-NHC Complex WOS:000474698500001 published article about ASYMMETRIC TRANSFER HYDROGENATION; HETEROCYCLIC CARBENE COMPLEXES; MANGANESE; LIGANDS; RUTHENIUM; MECHANISM; ACETOPHENONE; REDUCTION; IRIDIUM; RHODIUM in [van Putten, Robbert; Benschop, Joeri; de Munck, Vincent J.; Filonenko, Georgy A.; Pidko, Evgeny A.] Delft Univ Technol, Fac Sci Appl, Inorgan Syst Engn Grp, Dept Chem Engn, Maasweg 9, NL-2629 HZ Delft, Netherlands; [Weber, Manuela; Mueller, Christian] Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 34-36, D-14195 Berlin, Germany in 2019.0, Cited 42.0. Category: benzodioxans. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Catalytic reductions of carbonyl-containing compounds are highly important for the safe, sustainable, and economical production of alcohols. Herein, we report on the efficient transfer hydrogenation of ketones catalyzed by a highly potent Mn(I)-NHC complex. Mn-NHC 1 is practical at metal concentrations as low as 75 ppm, thus approaching loadings more conventionally reserved for noble metal based systems. With these low Mn concentrations, catalyst deactivation is found to be highly temperature dependent and becomes especially prominent at increased reaction temperature. Ultimately, understanding of deactivation pathways could help close the activity/stability-gap with Ru and Ir catalysts towards the practical implementation of sustainable earth-abundant Mn-complexes.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact van Putten, R; Benschop, J; de Munck, VJ; Weber, M; Muller, C; Filonenko, GA; Pidko, EA or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem