Day: October 21, 2021

In 2020.0 EUR J MED CHEM published article about BREAST-CANCER; CRYSTAL-STRUCTURE; CDK INHIBITORS; AGENTS DESIGN; APOPTOSIS; CELLS; IX; ENHANCEMENT; DERIVATIVES; SELECTIVITY in [Said, Mohamed A.; Soliman, Dalia H.] Egyptian Russian Univ, Coll Pharm, Dept Pharmaceut Chem, POB 11829, Cairo, Egypt; [Eldehna, Wagdy M.] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, POB 33516, Kafrelsheikh, Egypt; [Nocentini, Alessio; Bonardi, Alessandro; Supuran, Claudiu T.] Univ Florence, Dept NEUROFARBA, Sect Pharmaceut & Nutraceut Sci, Polo Sci, Via U Schiff 6, I-50019 Florence, Italy; [Nocentini, Alessio; Bonardi, Alessandro; Gratteri, Paola] Univ Firenze, Dept NEUROFARBA, Pharmaceut & Nutraceut Sect, Via U Schiff 6, I-50019 Florence, Italy; [Nocentini, Alessio; Bonardi, Alessandro; Gratteri, Paola] Univ Firenze, Lab Mol Modeling Cheminformat & QSAR, Via U Schiff 6, I-50019 Florence, Italy; [Fahim, Samar H.; Abou-Seri, Sahar M.] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Kasr El Aini St,POB 11562, Cairo, Egypt; [Elgazar, Abdullah A.] Kafrelsheikh Univ, Fac Pharm, Dept Pharmacognosy, POB 33516, Kafrelsheikh, Egypt; [Krystof, Vladimir] Palacky Univ, Lab Growth Regulators, Slechtitelu 27, Olomouc 78371, Czech Republic; [Krystof, Vladimir] Czech Acad Sci, Inst Expt Bot, Slechtitelu 27, Olomouc 78371, Czech Republic; [Soliman, Dalia H.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, POB 11471, Cairo, Egypt; [Abdel-Aziz, Hatem A.] Natl Res Ctr, Dept Appl Organ Chem, Cairo 12622, Egypt; [Krystof, Vladimir] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, Hnevotinska 5, Olomouc 77900, Czech Republic in 2020.0, Cited 56.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

In the present study, we report the design and synthesis of novel CAN508 sulfonamide-based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with potential CDK inhibitory activity. A bioisosteric replacement approach was adopted to replace the phenolic OH of CAN508 with a sulfamoyl group to afford compound 4. Thereafter, a ring-fusion approach was utilized to furnish the 5/5 fused imidazopyrazoles 8a-e which were subsequently expanded to 6/5 pyrazolopyrimidines 9a-h and 10a-e. All the synthesized analogues were evaluated for their inhibitory activity toward isoforms hCA I, II, IX and XII. The target tumor-associated isoforms hCA IX and XII were effectively inhibited with KIs ranges 6-67.6 and 10.1-88.6 nM, respectively. Furthermore, all compounds were evaluated for their potential CDK2 and 9 inhibitory activities. Pyrazolopyrimidines 9d, 9e and 10b displayed weak CDK2 inhibitory activity (IC50 = 6.4, 8.0 and 11.6 mu M, respectively), along with abolished CDK9 inhibitory activity. This trend suggested that pyrazolopyrimidine derivatives merit further optimization to furnish more effective CDK2 inhibitor lead. On account of their excellent activity and selectivity towards hCA IX and XII, pyrazolopyrimidines 10 were evaluated for their anti-proliferative activity toward breast cancer MCF-7 and MDA-MB-468 cell lines under normoxic and hypoxic conditions. The most potent anti-proliferative agents 10a, 10c and 10d significantly increased cell percentage at sub-G1 and G2-M phases with concomitant decrease in the S phase population in MCF-7 treated cells. Finally, a docking study was undertaken to investigate the binding mode for the most selective hCA IX and XII inhibitors 10a-e, within hCA II, IX and XII active sites. (C) 2020 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Krystof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 ASIAN J ORG CHEM published article about DEFECTS; QUINAZOLINONES; OPTIMIZATION; MOF in [Linh Ho Thuy Nguyen; Trang Thi Thu Nguyen; Thi Dang, Y.; Tan Le Hoang Doan] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Ctr Innovat Mat & Architectures INOMAR, Ho Chi Minh City 721337, Vietnam; [Linh Ho Thuy Nguyen; Trang Thi Thu Nguyen; Phuong Hoang Tran; Tan Le Hoang Doan] Vietnam Natl Univ Ho Chi Minh City, Dept Organ Chem, Fac Chem, Univ Sci, Ho Chi Minh City 721337, Vietnam in 2019.0, Cited 50.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

Zr-based metal-organic frameworks have been considered promising heterogeneous catalysts in various reactions. It has been proven that the defect sites in these frameworks, which result from deficiency of linkers, could act as the reaction active sites. In this work, microwave irradiation was used for rapid synthesis and increasing defects on Zr-6 clusters of metal-organic framework UiO-66. Powder X-ray diffraction, thermal gravimetric analysis, and N-2 sorption isotherms were performed to characterize and calculate the defect number in the framework. UiO-66 prepared by microwave method for a few minutes could reach 1.8 missing linkers per cluster. The material with acetic acid as a co-catalyst showed highly heterogeneous catalytic activity in the solvent-free heterocyclization of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and ketones/aldehydes. The synthetic scheme consisted of zirconium cluster catalysed carbonyl group of anthranilamide to achieve the C-N propitious combination and succeeding ring closure process.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Nguyen, LHT; Nguyen, TTT; Dang, YT; Tran, PH; Doan, TLH or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about ALKYL-ARYL KETONES; IR-F-BINAPHANE; ENANTIOSELECTIVE HYDROGENATION; IDENTIFICATION; SALTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772155, 21402155, 21602172]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Wu, ZT; Du, SZ; Gao, GR; Yang, WK; Yang, XY; Huang, HZ; Chang, MX. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Product Details of 100-19-6

The secondary amine participating asymmetric reductive amination remains an unsolved problem in organic synthesis. Here we show for the first time that secondary amines are capable of effectively serving as N-sources in direct asymmetric reductive amination to afford corresponding tertiary chiral amines with the help of a selected additive set under mild conditions (0-25 degrees C). The applied chiral phosphoramidite ligands are readily prepared from BINOL and easily modified. Compared with common tertiary chiral amine synthetic methods, this procedure is much more concise and scalable, as exemplified by the facile synthesis of rivastigmine and N-methyl-1-phenylethanamine.

Product Details of 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wu, ZT; Du, SZ; Gao, GR; Yang, WK; Yang, XY; Huang, HZ; Chang, MX or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. In 2019.0 MOL DIVERS published article about BENZAMIDE; DISCOVERY; ALPHA; ACIDS in [Nian, Si-Yun; Jiang, Zheng-Li] Taizhou Hosp Zhejiang Prov, Dept Clin Pharm, Xi Men St 150, Linhai 317000, Zhejiang, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping; Xiao, Ying] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 201203, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping] Aurisco Pharmaceut Yangzhou Co Ltd, Yangzhou 225100, Jiangsu, Peoples R China; [Huang, Mo-Han; Zhou, Yi-Huan; Tan, Xiang-Duan] Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China in 2019.0, Cited 21.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC50 = 7.8 +/- 1.1 mu M) showed better activity compared to SIPI-7623 (IC50 = 40.8 +/- 1.7 mu M) and guggulsterone (IC50 = 45.9 +/- 1.1 mu M). Docking of A-11 in FXR’s ligand-binding domain was also studied.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Nian, SY; Wang, GP; Jiang, ZL; Xiao, Y; Huang, MH; Zhou, YH; Tan, XD or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 1-(4-Nitrophenyl)ethanone. In 2019.0 J ORG CHEM published article about 3+3 ANNULATION REACTION; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; MICHAEL ADDITION; CYCLIZATION REACTIONS; EFFICIENT SYNTHESIS; SPIROPYRAZOLONES; CASCADE; CYCLOADDITION; EPOXIDATION in [Shen, Shou-Jie; Du, Xiao-Li; Zhao, Ming-Gang] Shanxi Normal Univ, Key Lab Magnet Mol, Magnet Informat Mat Minist Educ, Sch Chem & Mat Sci, Linfen 041004, Peoples R China; [Xu, Xiao-Li; Liang, Jin-Yan] Shanxi Normal Univ, Coll Life Sci, Linfen 041004, Peoples R China in 2019.0, Cited 70.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The regioselective N-addition/substitution reaction between alpha-alkylidene pyrazolinones and propargyl sulfonium salts has been developed to construct functionalized allylthio-containing pyrazolones with moderate to excellent yields. alpha-Alkylidene pyrazolinones act as N-nucleophilic agents which are distinguished from reported C-nucleophilic reactions. Excellent regioselectivity, readily available starting materials, the broad range of substrates, gram-scale synthesis, and simple operation illustrate the synthetic advantages of this new reaction pathway.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Shen, SJ; Du, XL; Xu, XL; Zhao, MG; Liang, JY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about DEFECTIVE GRAPHENE; ELECTROCATALYTIC ACTIVITY; REDUCTION; CATALYSTS; FRAMEWORKS; EVOLUTION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21306132]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Li, GZ; Zheng, SY; Wang, L; Zhang, XW. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. SDS of cas: 100-19-6

Chemoselective hydrogenation of nitroarenes to anilines is of great importance for the manufacture of pharmaceuticals, fine chemicals, and dyes. In this study, a series of metal-free N-doped carbon nanotubes (NCNTs) have been prepared by the carbonization of in situ polymerized pyrrole on CNTs. The concentration of pyrrole, pyrolysis temperature, and the outside diameter of CNTs were investigated to improve the catalytic performance. As characterized by Raman and X-ray photoelectron spectroscopy (XPS), the optimal catalyst (NCNTs-800) possessed a unique structure doped with the same content of pyrrolic N and graphitic N. The activity and selectivity of NCNTs-800 have been evaluated for the selective hydrogenation of substituted nitroarenes. Highly selective hydrogenation of the nitro group of 12 different substrates has been achieved on NCNTs-800, even in the presence of a fragile iodo group. The hydrogenation reaction on N-doped CNTs from polypyrrole involved a mixture of different hydrogen species including nonpolar H radicals. In addition, stability and recyclability of NCNTs-800 have been tested.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Li, GZ; Zheng, SY; Wang, L; Zhang, XW or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Amininasab, SM; Esmaili, S; Shami, Z in [Amininasab, S. Mojtaba; Esmaili, Sahereh; Shami, Zahed] Univ Kurdistan, Fac Sci, Dept Chem, Polymer Chem Res Lab, Sanandaj 6617715175, Iran published High-performance polyimides based on pyridine and xanthene pendant groups; synthesis, characterization, photoactivity, thermal, antibacterial, and Cr(VI) ion adsorption properties in 2020.0, Cited 44.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A group of new polyimides (PIs) containing xanthene bulky groups and heterocyclic pyridine ring were synthesized by polycondensation reaction by using new symmetric and asymmetric diamines with available dianhydrides. The prepared diamines and PIs were characterized by Fourier transform infrared, elemental analysis, and proton nuclear magnetic resonance spectroscopy and carbon nuclear magnetic resonance spectroscopy. The PIs have desirable solubility in common aprotic solvents like dimethyl sulfoxide, N-methyl-2-pyrrolidone, dimethylacetamide, and pyridine as a less polar solvent. The PIs with inherent viscosities in the range of 0.51-0.72 dL/g were amorphous in nature, showed glass transition temperatures (T(g)s) of about 270-300 degrees C, and 10% weight loss at temperatures 384-443 degrees C. They showed fluorescence emission (quantum yield 7-12%) due to the presence of xanthene and pyridine groups in their structure. The prepared PIs showed tensile strength of 81-91 MPa with elongation at break of 19-23%. The antibacterial properties of the PIs against Gram negative and Gram positive bacteria and funguses were investigated. Also, a membrane of PI prepared by electrospinning method was used for the removal of different concentrations of Cr(VI) from aqueous solutions.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Amininasab, SM; Esmaili, S; Shami, Z or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. Kilic, A; Balci, TE; Arslan, N; Aydemir, M; Durap, F; Okumu, V; Tekin, R in [Kilic, Ahmet; Balci, Tubba Ersayan] Harran Univ, Art & Sci Fac, Chem Dept, TR-63190 Sanliurfa, Turkey; [Arslan, Nevin] Sirnak Univ, Fac Agr, Dept Field Crops, TR-73000 Sirnak, Turkey; [Aydemir, Murat; Durap, Feyyaz] Dicle Univ, Sci Fac, Dept Chem, TR-21280 Diyarbakir, Turkey; [Okumu, Veysi] Univ Siirt, Fac Sci & Art, Dept Biol, TR-56100 Siirt, Turkey; [Tekin, Recep] Dicle Univ, Dept Infect Dis & Clin Microbiol, Fac Med, TR-21280 Diyarbakir, Turkey published Synthesis of cis-1,2-diol-type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation in 2020.0, Cited 69.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Two cis-1,2-diol-type chiral ligands (T-1 and T-2) and their tri-coordinated chiral dioxaborinane (T(1-2)B(1-2)) and four-coordinated chiral dioxaborinane adducts with 4-tert-butyl pyridine sustained by N -> B dative bonds (T(1-2)B(1-2)-N) were synthesized and characterized by various spectroscopic techniques such as NMR (H-1, C-13, and B-11), FT-IR and UV-Vis spectroscopy, LC-MS/MS, and elemental analysis. It was suggested that both ferrocene and trifluoromethyl groups played key roles in the catalytic and biological studies because they could tune the solubility of the chiral dioxaborinane complexes and adjust the strength of intermolecular interactions. To assess the biological activities of newly synthesized chiral dioxaborinane compounds, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, reducing power, antibacterial, DNA binding, and DNA cleavage activities were tested. Then, all chiral dioxaborinane complexes were investigated as catalysts for the asymmetric transfer hydrogenation of various ketones under suitable conditions. The results indicated that the chiral dioxaborinane catalysts performed well with high yields.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Kilic, A; Balci, TE; Arslan, N; Aydemir, M; Durap, F; Okumu, V; Tekin, R or concate me.. Quality Control of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Hydration of terminal alkynes catalyzed by cobalt corrole complex WOS:000579003400002 published article about COUNTERION in [Lai, Jia-Wei; Liu, Zhao-Yang; Chen, Xiao-Yan; Zhang, Hao; Liu, Hai-Yang] South China Univ Technol, Dept Chem, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China in 2020.0, Cited 36.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Cobalt(III) corrole was firstly applied to the hydration of terminal alkynes. The alkyne hydration proceeded in good to excellent yield with 0.03 to 0.3 mol% cobalt corrole catalyst loading. A wide range of substrates were tolerated. Particularly, the reaction can give 90% yield in a gram scale experiment. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Lai, JW; Liu, ZY; Chen, XY; Zhang, H; Liu, HY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies published in 2019.0, Reprint Addresses Agrawal, N (corresponding author), GLA Univ, Inst Pharmaceut Res, Mathura, UP, India.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Selective monoamine oxidase B inhibitors are potential drug candidates for the treatment of Parkinson’s disease. A series of phenyl substituted isoxazole carbohydrazides was designed by structural modification of isocarboxazid, a nonselective MAO inhibitor and evaluated as inhibitors of MAO-A and MAO-B. The compounds were not able to inhibit MAO-A significantly, but most of the compounds exhibited potent inhibitory activity against MAO-B. The enzyme kinetic study of the most active compounds 5d, 5-phenyl-N ‘-(1-(p-tolyl)ethylidene)isoxazole-3-carbohydrazide and 5g, N ‘-(1-(3,4-dimethoxyphenyl)ethylidene)-5-phenylisoxazole-3-carbohydrazide displayed reversible and competitive MAO-B inhibition. In molecular modeling studies, compounds 5d and 5g exhibited strong binding affinity on MAO-B active site. The administration of compounds 5d and 5g exhibited prevention of MPTP-induced Parkinsonism as indicated by footprint analysis and horizontal wire tests. Further optimization studies are essential to exploit their potential for MAO-B associated neurodegenerative pathologies.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Agrawal, N; Mishra, P or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem