Day: October 12, 2021

An article Continuous-Flow Hydrogenation and Reductive Deuteration of Nitriles: a Simple Access to alpha,alpha-Dideutero Amines WOS:000486789800001 published article about D EXCHANGE-REACTIONS; SELECTIVE DEUTERATION; SODIUM-BOROHYDRIDE; ISOTOPIC EXCHANGE; CARBOXYLIC-ACID; DEUTERIUM; EFFICIENT; RHODIUM; HETEROCYCLES; MECHANISM in [Meszaros, Rebeka; Peng, Bai-Jing; Otvos, Sandor B.; Fulop, Ferenc] Univ Szeged, Inst Pharmaceut Chem, Eotvos U 6, H-6720 Szeged, Hungary; [Peng, Bai-Jing; Yang, Shyh-Chyun] Kaohsiung Med Univ, Sch Pharm, Coll Pharm, Kaohsiung 807, Taiwan; [Otvos, Sandor B.; Fulop, Ferenc] Hungarian Acad Sci, MTA SZTE Stereochem Res Grp, Eotvos U 6, H-6720 Szeged, Hungary; [Otvos, Sandor B.] Graz Univ, NAWI Graz, Inst Chem, Heinrichstr 28, A-8010 Graz, Austria; [Yang, Shyh-Chyun] Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, Coll Pharm, Kaohsiung 807, Taiwan; [Yang, Shyh-Chyun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan in 2019, Cited 61. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. SDS of cas: 86-29-3

A simple and efficient continuous flow methodology has been developed for hydrogenation and reductive deuteration of nitriles to yield primary amines and also valuable alpha,alpha-dideutero analogues. Raney nickel proved to be a useful catalyst for the transformation of a wide range of nitriles under reasonably mild conditions with excellent deuterium incorporation (>90 %) and quantitative conversion. Among known model compounds, three new deuterated primary amines were prepared. The large-scale synthesis of deuterated tryptamine was also carried out to deliver 1.1 g product under flow conditions.

SDS of cas: 86-29-3. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Meszaros, R; Peng, BJ; Otvos, SB; Yang, SC; Fulop, F or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

COA of Formula: C8H7NO3. Authors Yang, LL; Chen, Y; He, JL; Njoya, EM; Chen, JJ; Liu, SY; Xie, CQ; Huang, WZ; Wang, F; Wang, ZY; Li, YZ; Qian, S in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Yang, Lingling; Chen, Yang; Chen, Jianjun; Liu, Siyan; Xie, Congqiang; Huang, Wenze; Wang, Zhouyu; Qian, Shan] Xihua Univ, Sch Food & Bioengn, Dept Pharmaceut Engn, Chengdu 610039, Sichuan, Peoples R China; [He, Junlin; Li, Yuzhi] Chengdu Univ Tradit Chinese Med, Coll Pharm, Key Lab Systemat Res Dev & Utilizat Chinese Med R, Chengdu 610091, Sichuan, Peoples R China; [Njoya, Emmanuel Mfotie; Wang, Fei] Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu 610041, Sichuan, Peoples R China in 2019.0, Cited 38.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships (SARs). Among these, compound 35 displayed the most IDO1 inhibitory potency with an IC50 value of 0.74 mu M in an enzymatic assay and 1.37 mu M in HeLa cells. Quantitative analysis of the Western blot results indicated that 35 significantly decreased the INF gamma-induced IDO1 expression in a concentration-dependent manner. In addition, 35 showed promising TDO inhibition with an IC50 value of 2.93 mu M in the enzymatic assay and 7.54 mu M in A172 cells. Moreover, compound 35 exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that 1H-indazole derivative 35 is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment.

COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Yang, LL; Chen, Y; He, JL; Njoya, EM; Chen, JJ; Liu, SY; Xie, CQ; Huang, WZ; Wang, F; Wang, ZY; Li, YZ; Qian, S or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 CATAL COMMUN published article about WACKER-TYPE OXIDATION; TERMINAL OLEFINS; METHYL KETONES; HYDROGEN-PEROXIDE; METAL; CATALYSTS; NANOPARTICLES; DERIVATIVES; STYRENE; ALKENES in [Gao, Xi; Zhou, Jianhao; Peng, Xinhua] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China in 2019.0, Cited 35.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. HPLC of Formula: C8H7NO3

Selective oxidation of olefin derivatives to ketones has made innovative development over palladium(0) supported on reduced graphene oxide. Compared to traditional Wacker oxidation, the novel method offers an economical and environment-friendly option by using graphene oxide (GO) as a ‘solid weak acid’ instead of classical homogeneous catalysts like H2SO4 and CF3COOH. X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscope and transmission electron microscopy images of Pd degrees/RGO showed that the nanoscaled Pd particles generated at the flake structure of reduced graphene oxide. Under optimized condition, up to 44 kinds of ketones with different structures can be prepared with excellent yields.

HPLC of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Gao, X; Zhou, JH; Peng, XH or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Ag2CO3-mediated direct functionalization of alkyl nitriles: Facile synthesis of gamma-ketonitriles through nitrile alkylation of enol acetates published in 2019.0. HPLC of Formula: C8H7NO3, Reprint Addresses Cheng, P (corresponding author), Hunan Agr Univ, Key Lab Tradit Chinese Vet Med Hunan Prov, Changsha 410128, Hunan, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Direct C(sp3)-H functionalization of alkyl nitriles is a low toxic and facile route to nitrile-containing compounds. In this research, the Ag2CO3-mediated nitrile methylenation of enol acetates is developed to prepare gamma-ketonitriles through the direct C(sp(3))-H oxidative functionalization of acetonitrile. A radical pathway is proposed, and acetonitrile serves both as solvent and CN-containing radical source. (C) 2019 Elsevier Ltd. All rights reserved.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Cheng, P; Wang, W; Wang, L; Zeng, JG; Reiser, O; Liang, Y or concate me.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 1-(4-Nitrophenyl)ethanone. In 2019.0 J ORG CHEM published article about C-H FUNCTIONALIZATION; ONE-POT SYNTHESIS; EFFICIENT CONSTRUCTION; SUBSTITUTED CARBAZOLES; CLAUSINE-L; INDOLES; ANNULATION; ALKALOIDS; ACID; CYCLIZATION in [Chen, Shanping; Jiang, Pingyu; Wang, Pu; Pei, Yong; Huang, Huawen; Xiao, Fuhong; Deng, Guo-Jun] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China in 2019.0, Cited 81.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A novel method was developed for the synthesis of substituted carbazoles from commercially available starting materials under metal-free conditions. This strategy involves a [1s,6s] sigmatropic shift step and introduces an electron-withdrawing ester substituent at the C2 position of the carbazole ring. The present protocol afforded the desired carbazole derivatives with good regioselectivity and well functional group tolerance. DFT calculations were carried out to support the reaction pathway.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Chen, SP; Jiang, PY; Wang, P; Pei, Y; Huang, HW; Xiao, FH; Deng, GJ or concate me.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article A new cobalt triangular prism supramolecular flask: Encapsulation of a quinhydrone cofactor for hydrogenation of nitroarenes with high selectivity and efficiency WOS:000498316900017 published article about PRIMARY AMINES; AMINATION; CATALYST; RECOGNITION; GENERATION; NITRILES; ALCOHOLS; WATER in [Zheng, Sijia; Zhao, Liang; Wei, Jianwei; He, Cheng; Liu, Guangzhou; Duan, Chunying] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China in 2019.0, Cited 40.0. HPLC of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new M6L3 metal-organic triangular prism host Co-L-1 was synthesized that contains a sufficiently large cavity for encapsulation of a quinhydrone (QHQ) electron transporter to form charge-transfer complexes for accelerating electron delivery. Through the strong coordinating ability of the ONP chelator, a suitable redox potential was obtained for the combination of light-driven proton reduction with the selective hydrogenation of nitro groups. The experimental results showed that the regulation of redox potential is very beneficial for hydrogen production and that the introduction of QHQ accelerates electron transfer and increases the reaction rate. Control experiments based on an inhibitor and a mononuclear compound resembling the cobalt corner of the triangular prism suggest enzyme-like behaviour. This synthetic platform, in which the supramolecular systems exhibit high activity and stability, provides an alternative strategy to selectively hydrogenate nitroarenes using light as a clean energy source.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zheng, SJ; Zhao, L; Wei, JW; He, C; Liu, GZ; Duan, CY or concate me.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Name: 1-(4-Nitrophenyl)ethanone. I found the field of Chemistry very interesting. Saw the article Unlocking the catalytic potential of tris(3,4,5-trifluorophenyl)borane with microwave irradiation published in 2019.0, Reprint Addresses Melen, RL (corresponding author), Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

The catalytic activity of tris(3,4,5-trifluorophenyl)borane has been explored in the 1,2-hydroboration reactions of unsaturated sub-strates. Under conventional conditions, the borane was found to be active only in the hydroboration of aldehyde, ketone and imine substrates, with alkenes and alkynes not being reduced effectively. The use of microwave irradiation on the other hand has permitted alkenes and alkynes to be hydroborated in good yields.

Name: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Carden, JL; Gierlichs, LJ; Wass, DF; Browne, DL; Melen, RL or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 1-(4-Nitrophenyl)ethanone. In 2021.0 ORG LETT published article about ASYMMETRIC-SYNTHESIS; ALPHA-ALKYLATION; ALLYLIC ALCOHOLS; INHIBITORS; DISCOVERY; ALDEHYDES; BENZYLATION; ARYLATION in [Zhu, Xiaoyi; Li, Ruibo; Yao, Hequan; Lin, Aijun] China Pharmaceut Univ, Dept Med Chem, State Key Lab Nat Med, Jiangsu Key Lab Bioact Nat Prod Res, Nanjing 210009, Peoples R China in 2021.0, Cited 52.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C-C bonds were formed in one pot.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zhu, XY; Li, RB; Yao, HQ; Lin, AJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Ang, HT; Rygus, JPG; Hall, DG in [Ang, Hwee Ting; Rygus, Jason P. G.; Hall, Dennis G.] Univ Alberta, Dept Chem, Centennial Ctr Interdisciplinary Sci, Edmonton, AB T6G 2G2, Canada published Two-component boronic acid catalysis for increased reactivity in challenging Friedel-Crafts alkylations with deactivated benzylic alcohols in 2019.0, Cited 47.0. Category: benzodioxans. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A general and efficient boronic acid catalyzed Friedel-Crafts alkylation of arenes with benzylic alcohols was previously developed for the construction of unsymmetrical diarylmethane products (X. Mo, J. Yakiwchuk, J. Dansereau, J. A. McCubbin and D. G. Hall, J. Am. Chem. Soc., 2015, 137, 9694). Highly electron-deficient benzylic alcohols, however, were ineffective coupling partners due to the increased difficulty of C-O bond ionization. Herein, we report the use of perfluoropinacol as an effective co-catalyst to improve the reactivity of a boronic acid catalyst in the Friedel-Crafts benzylations of electronically deactivated primary and secondary benzylic alcohols. According to spectroscopic studies, it is believed that perfluoropinacol condenses with the arylboronic acid catalyst to form a highly electrophilic and Lewis acidic boronic ester. This in situ formed species enables a more facile ionization of the benzylic alcohols likely through a mode of activation promoted by a Lewis acid assisted hydronium Bronsted acid generated from the interactions of the transient boronic ester with hexafluoroisopropanol solvent and water.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Ang, HT; Rygus, JPG; Hall, DG or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Copper-catalyzed coupling of anthranils and alpha-keto acids: direct synthesis of alpha-ketoamides published in 2019.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone, Reprint Addresses Zou, LH (corresponding author), Jiangnan Univ, Minist Educ, Sch Pharmaceut Sci, Key Lab Carbohydrate Chem & Biotechnol, Lihu Ave 1800, Wuxi 214122, Jiangsu, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Copper-catalyzed coupling of alpha-keto acids with anthranils is reported for the synthesis of alpha-ketoamides. This process involves N-O/C-O bond cleavages and C-N bond formation. Furthermore, the decarboxylation of alpha-keto acids can be successfully suppressed under redox-neutral conditions.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Li, PG; Zhu, H; Fan, M; Yan, C; Shi, K; Chi, XW; Zou, LH or concate me.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem