Day: October 9, 2021

I found the field of Chemistry very interesting. Saw the article Hydration of terminal alkynes catalyzed by cobalt corrole complex published in 2020.0. Quality Control of 1-(4-Nitrophenyl)ethanone, Reprint Addresses Liu, HY (corresponding author), South China Univ Technol, Dept Chem, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Cobalt(III) corrole was firstly applied to the hydration of terminal alkynes. The alkyne hydration proceeded in good to excellent yield with 0.03 to 0.3 mol% cobalt corrole catalyst loading. A wide range of substrates were tolerated. Particularly, the reaction can give 90% yield in a gram scale experiment. (C) 2020 Elsevier Ltd. All rights reserved.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Lai, JW; Liu, ZY; Chen, XY; Zhang, H; Liu, HY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Microwave-Assisted Synthesis as an Efficient Method to Enhance the Catalytic Activity of Zr-Based Metal Organic Framework UiO-66 in a Heterocyclization Reaction WOS:000500019700001 published article about DEFECTS; QUINAZOLINONES; OPTIMIZATION; MOF in [Linh Ho Thuy Nguyen; Trang Thi Thu Nguyen; Thi Dang, Y.; Tan Le Hoang Doan] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Ctr Innovat Mat & Architectures INOMAR, Ho Chi Minh City 721337, Vietnam; [Linh Ho Thuy Nguyen; Trang Thi Thu Nguyen; Phuong Hoang Tran; Tan Le Hoang Doan] Vietnam Natl Univ Ho Chi Minh City, Dept Organ Chem, Fac Chem, Univ Sci, Ho Chi Minh City 721337, Vietnam in 2019.0, Cited 50.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Quality Control of 1-(4-Nitrophenyl)ethanone

Zr-based metal-organic frameworks have been considered promising heterogeneous catalysts in various reactions. It has been proven that the defect sites in these frameworks, which result from deficiency of linkers, could act as the reaction active sites. In this work, microwave irradiation was used for rapid synthesis and increasing defects on Zr-6 clusters of metal-organic framework UiO-66. Powder X-ray diffraction, thermal gravimetric analysis, and N-2 sorption isotherms were performed to characterize and calculate the defect number in the framework. UiO-66 prepared by microwave method for a few minutes could reach 1.8 missing linkers per cluster. The material with acetic acid as a co-catalyst showed highly heterogeneous catalytic activity in the solvent-free heterocyclization of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and ketones/aldehydes. The synthetic scheme consisted of zirconium cluster catalysed carbonyl group of anthranilamide to achieve the C-N propitious combination and succeeding ring closure process.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Nguyen, LHT; Nguyen, TTT; Dang, YT; Tran, PH; Doan, TLH or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Cu-Catalyzed Diastereo- and Enantioselective Reactions of gamma,gamma-Disubstituted Allyldiboron Compounds with Ketones published in 2020.0. Product Details of 100-19-6, Reprint Addresses Meek, SJ (corresponding author), Univ North Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27599 USA.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A catalytic diastereo- and enantioselective method for the preparation of complex tertiary homoallylic alcohols containing a vicinal quaternary carbon stereogenic center and a versatile alkenylboronic ester is disclosed. Transformations are promoted by 5 mol % of a readily available copper catalyst bearing a bulky monodentate phosphoramidite ligand, which is essential for attaining both high dr and er. Reactions proceed with a wide variety of ketones and allylic 1,1-diboronate reagents, which enables the efficient preparation of diverse array of molecular scaffolds.

Product Details of 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zanghi, JM; Meek, SJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

HPLC of Formula: C8H7NO3. I found the field of Chemistry very interesting. Saw the article Porous FeO(OH) Dispersed on Mg-Al Hydrotalcite Surface for One-Pot Synthesis of Quinoline Derivatives published in 2021.0, Reprint Addresses Motokura, K (corresponding author), Tokyo Inst Technol, Sch Mat & Chem Technol, Dept Chem Sci & Engn, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268502, Japan.; Motokura, K (corresponding author), Japan Sci & Technol Agcy JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan.; Motokura, K (corresponding author), Yokohama Natl Univ, Dept Chem & Life Sci, Hodogaya Ku, 79-5 Tokiwadai, Yokohama, Kanagawa 2408501, Japan.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

The use of ubiquities elements such as iron instead of expensive precious metals as catalysts is one goal toward realizing environmentally benign synthetic chemistry. Here, we report that porous FeO(OH) dispersed on Mg-Al hydrotalcite acts as a bifunctional heterogeneous catalyst in the one-pot synthesis of 2-substituted quinoline derivatives through dehydrogenative oxidation-cyclization reactions. The catalyst was prepared by a simple grafting method using FeCl3 and Mg-Al hydrotalcite. The prepared porous FeO(OH) possesses a higher surface area than those previously reported for alpha-FeO(OH) particles. The one-pot quinoline synthesis proceeded effectively under non-noble-metal catalysis in air without requiring additional homogeneous bases or solvents.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Motokura, K; Ozawa, N; Sato, R; Manaka, Y; Chun, WJ or concate me.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. In 2021.0 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; DERIVATIVES; ANALOGS in [Huo, Xian-Sen; Jian, Xie-Er; Ou-Yang, Jie; Chen, Lin; Yang, Fang; Lv, Dong-Xin; You, Wen-Wei; Rao, Jin-Jun; Zhao, Pei-Liang] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China in 2021.0, Cited 10.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Y By removing 5-methyl and 6-acetyl groups in our previously reported compound 3, we designed a series of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential tubulin polymerization inhibitors. Among them, compound 5e displayed low nanomolar antiproliferative efficacy on HeLa cells which was 166-fold higher than the lead analogue 3. Interestingly, 5e displayed significant selectivity in inhibiting cancer cells over HEK-293 (normal human embryonic kidney cells). In addition, 5e dose-dependently arrested HeLa in G2/M phase through the alterations of the expression levels of p-cdc2 and cyclin B1, and caused HeLa cells apoptosis by regulation of expressions of cleaved PARP. Further evidence demonstrated that 5e effectively inhibited tubulin polymerization and was 3-fold more powerful than positive control CA-4. Moreover, molecular docking analysis indicated that 5e overlapped well with CA-4 in the colchicine-binding site. These studies demonstrated that 2,7-diaryl-[1,2,4]triazolo [1,5-a]pyrimidine skeleton might be used as the leading unit to develop novel tubulin polymerization inhibitors as potential anticancer agents. (C) 2021 Elsevier Masson SAS. All rights reserved.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Huo, XS; Jian, XE; Ou-Yang, J; Chen, L; Yang, F; Lv, DX; You, WW; Rao, JJ; Zhao, PL or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model WOS:000563047900068 published article about ENDOGENOUS PEROXYNITRITE; RATIOMETRIC DETECTION; NITRIC-OXIDE; LIVING CELLS; PROBE; HEPATOTOXICITY; VISUALIZATION; TOXICITY; STRESS; INJURY in [Cheng, Dan; Gong, Xiangyang; Wu, Qian; Yuan, Jie; Lv, Yun; Yuan, Lin; Zhang, Xiaobing] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Peoples R China in 2020.0, Cited 49.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Peroxynitrite (ONOO-), a highly reactive species, is profoundly involved in many physiological and pathological processes. Change of the ONOO- level usually indicates an abnormal body function. Thus, it is desired to develop a highly reliable ONOO- assay to elucidate its roles in a related disease environment. In this work, we have constructed a ratiometric molecule fluorescent probe RTFP toward ONOO- with high specificity by the combination strategy of probe screening and a rational design method. RTFP displayed excellent detection sensitivity (detection limit: 4.1 nM) and produced a highly ratiometric emission signal (130-fold). Leveraging this probe, we showed the change of ONOO- content in the free-fatty-acid-induced nonalcoholic fatty liver disease (NAFLD) and acetaminophen-induced drug-induced liver injury (DILI) cellular model and for the first time disclosed the involved mechanism of cytochrome P450 2E1 (CYP2E1) enzyme in NAFLD with a DILI pathological environment. Furthermore, RTFP also was utilized to visualize ONOO- fluctuation of living liver tissues in a high-fat-diet-caused NAFLD model. We expected that this probe may help the study of liver injury in the exploration of mechanism and signal path.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Cheng, D; Gong, XY; Wu, Q; Yuan, J; Lv, Y; Yuan, L; Zhang, XB or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Yakantham, T; Sreenivasulu, R; Alluraiah, G; Tej, MB; Raju, RR in [Yakantham, T.; Ramesh Raju, R.] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India; [Sreenivasulu, R.] Jawaharlal Nehru Technol Univ, Univ Coll Engn Autonomous, Dept Chem, Kakinada 533003, Andhra Pradesh, India; [Alluraiah, G.] SV Arts & Sci Coll, Dept Chem, Giddalur 523357, Andhra Pradesh, India; [Tej, M. B.] Sri Ramachandra Inst Higher Educ & Res, Dept Pharm, Chennai 600116, Tamil Nadu, India published Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives in 2019.0, Cited 12.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by H-1 and C-13 NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Yakantham, T; Sreenivasulu, R; Alluraiah, G; Tej, MB; Raju, RR or concate me.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Palladium-Catalyzed Direct alpha-Arylation of Arylacetonitriles with Aryl Tosylates and Mesylates WOS:000522338200014 published article about REDUCTIVE ELIMINATION; CARBON-CARBON; NITRILES; CYANOACETATE; HALIDES; LIGAND; HETEROARYL; COMPLEXES; EFFICIENT; ACETONE in [Yuen, On Ying; Chen, Xiangmeng; Wu, Junyu; So, Chau Ming] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Hung Hom, Kowloon, Hong Kong, Peoples R China; [Yuen, On Ying; Chen, Xiangmeng; Wu, Junyu; So, Chau Ming] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China; [So, Chau Ming] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen, Peoples R China in 2020, Cited 49. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. Product Details of 86-29-3

The first general palladium-catalyzed alpha-arylation of arylacetonitriles with aryl and heteroaryl sulfonates are reported. Pd(OAc)(2) associated with XPhos serves as the effective catalyst to facilitate this reaction. A broad range of electron-rich, -neutral, -deficient, and sterically hindered aryl/heteroaryl tosylates and mesylates are coupled with arylacetonitriles bearing different substituents to give the corresponding products in good to excellent yields. Catalyst loading down to 0.1 mol-% Pd was achieved, and 22 unprecedented compounds were synthesized from 43 demonstrated examples using this method. Its applicability with the modification of biological phenolic compounds was successfully demonstrated. The Pd/XPhos system catalyzed the alpha-arylation and followed by alkylation in one-pot sequential conditions, resulting in the direct synthesis of compounds containing quaternary center- and deuterium-containing compounds in good to excellent yields.

Product Details of 86-29-3. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Yuen, OY; Chen, XM; Wu, JY; So, CM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY in [Gu, Xiaoke; Li, Xin; Guan, Mingyu; Jiang, Chunyu; Song, Qinghua; Sun, Nan; Qiu, Jingying] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China; [Zou, Yueting; Zhou, Qingqing; Chen, Jing; Qiu, Jingying] Xuzhou Med Univ, Sch Pharm, Dept Pharmaceut Anal, Xuzhou 221004, Jiangsu, Peoples R China published Discovery of thiosemicarbazone-containing compounds with potent anti- proliferation activity against drug-resistant K562/A02 cells in 2020.0, Cited 27.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the most active compound 7e displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC50 value of 0.44 mu M. Notably, compound 7e exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound 7e could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, respectively. Overall, 7e may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Moi, D; Nocentini, A; Deplano, A; Balboni, G; Supuran, CT; Onnis, V in [Moi, Davide; Balboni, Gianfranco; Onnis, Valentina] Univ Cagliari, Unit Pharmaceut Pharmacol & Nutraceut Sci, Dept Life & Environm Sci, Via Osped 72, I-09124 Cagliari, Italy; [Nocentini, Alessio; Supuran, Claudiu T.] Univ Firenze, Pharmaceut & Nutraceut Sect, Dept NEUROFARBA, Via Ugo Schiff 6, I-50019 Florence, Italy; [Deplano, Alessandro] Pharmacelera, Placa Pau Vila 1,Sect 1,Edificio Palau Mar, Barcelona 08039, Spain published Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation in 2019.0, Cited 64.0. HPLC of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Four new series of aromatic sulfamates were synthesized and investigated for the inhibition of four human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I, II, IX, and XII. The reported derivatives, obtained by a sulfamoylation reaction of the corresponding phenolic precursors, bear 3,5-diarylpyrazoline moieties as spacers between the benzenesulfamate fragment which binds the zinc ion from the active site, and the tail of the inhibitor. Pyrazolines are biologically privileged scaffolds, endowed with versatile biological activity, such as an anti-proliferative action. The derivatives were tested for the inhibition of the cytosolic, hCA I and II (off target isoforms) and the trans-membrane, tumor-associated hCA IX and XII enzymes (anticancer drug targets). Generally, hCA I was not effectively inhibited, whereas many low nanomolar inhibitors were evidenced against hCA II (KIs in the range of 0.42-90.1 nM), IX (KIs in the range of 0.72-63.6 nM), and XII (KIs in the range of 0.88-85.2 nM). The best substitution fragments at the pyrazoline ring included for CA it a 4-sulfamic group on the 3-aryl and halogens on the 5-aryl or a methoxy group on the 3-aryl and a 4-sulfamate group on the 5-aryl; for CA IX and CA XII they included the sulfamic group on the 3- or 4-position of the 5-aryl and an electronwithdrawing group on the 4-postion of the 3-aryl ring. (C) 2019 Elsevier Masson SAS. All rights reserved.

HPLC of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Moi, D; Nocentini, A; Deplano, A; Balboni, G; Supuran, CT; Onnis, V or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem