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(matrix presented) A general and efficient procedure for the synthesis of N-aryl-substituted 4-piperidones was developed. The general methodology was applied to the synthesis of several different N-aryl-4-piperidones utilizing an expedient two-step process.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Presented is a rapid and general approach to functionalised 1-aza-adamantanetrione (AAT) donor-sigma-acceptor molecules from a phloroglucinol-derived trilactone, benzotrifuranone (BTF). Ten C 3-symmetric AATs bearing diverse aryl amide substituents are accessed in two synthetic steps: (1) the exhaustive ring opening of BTF with aromatic amine nucleophiles (performed in up to 91% yield) and (2) cyclisation with hexamethylenetetramine (performed in up to 75% yield). Additionally, stepwise ring opening of BTF allows synthesis of phloroglucinol intermediates with two unique aryl amide substituents and ultimately Cs-symmetric AATs. Of the novel AATs prepared, three (including the Cs-symmetric hybrid) are effective gelators of chlorinated solvents (critical gelation concentration (CGC)=0.2-0.4 wt%) and one, with naphthyl substituents, forms translucent gels from aromatic solvents (CGC0 ? 3 wt%). The combination of AATs with moderately electron-poor and electron-rich aromatic substituents results in functional complementarity and gelation at concentrations below what is required for the individual components. Electron microscopy of the gel morphologies shows high aspect ratio fibres underlying the gel network superstructures in most cases. Polarised optical microscopy has allowed imaging of representative native organogel phases, and reveals striking morphology differences between gels that also share different optical and/or thermal stability properties.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Read on for other articles about 2879-20-1Quality Control of 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone“.

Quality Control of 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. In a document type is Article, and a compound is mentioned, 2879-20-1, Name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, introducing its new discovery.

In this study, we report the synthesis of a series of chalcone?benzoxaborole hybrid molecules and the evaluation of their anticancer activity. Their anticancer potency and toxicity were tested on three human cancer cell lines and two normal cell lines. The 4-fluoro compound 15 was found to be the most potent compound with an IC50value of 1.4 muM on SKOV3 cells. The 4-iodo compound 18 and 3-methyloxy-4-amino compound 47 showed good potency on SKOV3 cells while exhibiting low toxicity on normal cells. This work extended the application of benzoxaboroles to the field of anticancer research.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Read on for other articles about 2879-20-1Quality Control of 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone“.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Compounds represented by Formula (I): 1or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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We describe an eco-friendly, practical and operationally simple procedure for the bis(methoxypropyl) ether-promoted oxidation of aromatic alcohols into aromatic carboxylic acids and aromatic ketones with atmospheric dioxygen as the sole oxidant. This chemical process is clean with high conversion and good selectivity, and an external initiator, catalyst, additive and base are not required. The virtue of this reaction is highlighted by its easily available and economical raw materials and excellent functional group tolerance (acid-, base- and oxidant-labile groups).

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem