Day: March 29, 2021

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Dettbarn, WD, once mentioned the application of 104-03-0, Name is 4-Nitrophenylacetic acid, molecular formula is C8H7NO4, molecular weight is 181.1455, MDL number is MFCD00007383, category is benzodioxans. Now introduce a scientific discovery about this category, Computed Properties of C8H7NO4.

Different role of carboxylesterases in toxicity and tolerance to paraoxon and DFP

The contribution of carboxylesterase (CarbE) to toxicity and tolerance to the organophosphorus anticholinesterases; (OP-antiChE) paraoxon (diethyl p-nitrophenyl phosphate) and DFP (diisopropylphosphorofluoridate) was investigated in rats. Daily injections (20 days) of paraoxon (0.33 mu mol/kg) or DFP (2.72 mu mol/kg) reduced AChE activity in brain to 29 or 16% and in diaphragm to 58 or 54%, respectively. The animals tolerated an accumulated 6-fold LD50 dose and survived an LD90 dose of carbachol, indicating tolerance to this cholinergic agonist. A single dose of paraoxon or DFP significantly reduced CarbE activity of plasma, lung and liver. After paraoxon, rapid recovery was seen of plasma and liver CarbE while recovery after DFP was much slower. Daily pretreatment with the CarbE inhibitors CBDP (2-[o-cresyl]-4H-1,2,3-benzodioxa- phosphorin-2-oxide) (7.22 mu mol/kg, s.c.) or iso-OMPA (tetraisopropylpyrophosphoramide) (8.76 mu mol/kg, i.p.), followed by paraoxon (0.33 mu mol/kg, s.c.) 30 min later, prevented the development of tolerance to paraoxon and potentiated its toxicity. Rats died on day four of the combined treatment. The CarbE inhibitors neither potentiated the DFP toxicity, nor prevented tolerance development to DFP. We conclude that rat plasma CarbE provides a significant protection against paraoxon toxicity because its rapid reactivation can reduce the toxicity of repeated paraoxon applications and thus contribute to tolerance development. This same mechanism does not apply to DFP toxicity, as inhibition of CarbE of plasma, liver and lung neither potentiated its toxicity, nor prevented tolerance development. These findings confirm previous observations that CarbE detoxification is of greater importance for highly toxic OP-antiChEs such as nerve agents and paraoxon than for less toxic ones such as DFP. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 104-03-0, Computed Properties of C8H7NO4.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is an experimental science, Application In Synthesis of (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 50-69-1, Name is (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal, molecular formula is C5H10O5, belongs to benzodioxans compound. In a document, author is WELL, M.

SYNTHESIS AND NMR-SPECTROSCOPY OF PHOSPHORANES WITH 1,3,2-DIOXA-4,5-NAPHTHOPHOSPHOLE RING

The reaction of naphthalene-2,3-diol 1 with PCl3 was found to furnish the hydridophosphorane 3, with PCl5 the chlorophosphorane 4 was formed. The reaction of the fluorophosphoranes, RPF4 [R=F, (i)Pr, CH2SiMe3, CH2Cl, Ph] with the bis(trimethylsilyl) derivative of 1, 2 yielded the corresponding spirocyclic phosphoranes, 5-9 by cleavage of the Si-O bond and elimination of Me3SiF. The difluorophosphoranes, R2PF3 [R=Me, Ph] reacted with 2 to form the monocyclic phosphoranes, 10 and 11, where the fluorine atom occupies an axial position at trigonal-bipyramidal (TBP) phosphorus- The structure of compound 11 was confirmed by single crystal X-ray analysis of its dichloromethane hemisolvate at -95-degrees-C. The geometry at phosphorus is trigonal-bipyramidal. whereby the naphthalenedioxy ligand spans an axial and an equatorial site. Me2PF3 reacted with tetrakis(1,2,4.5-trimethylsiloxy)benzene to form the bifunctional benzodioxa-lambda5-phosphole, 12.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 50-69-1. Application In Synthesis of (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 37595-74-7, Name is 1,1,1-Trifluoro-N-phenyl-N-((trifluoromethyl)sulfonyl)methanesulfonamide, SMILES is C1=C(N([S](C(F)(F)F)(=O)=O)[S](C(F)(F)F)(=O)=O)C=CC=C1, belongs to benzodioxans compound. In a document, author is Bilgin, Ahmet, introduce the new discover, Computed Properties of C8H5F6NO4S2.

Novel porphyrazines containing peripherally functionalized macrocyclic (N2O2, N2S2) units: Synthesis and characterization

Novel maleonitrile moieties were synthesized by cyclization of 2,3-bis[(2-pyridylmethyl)amino]-2(Z)-butene-1,4-dinitrile with 1,2-bis(2-iodoethoxy)-4-nitrobenzene or o-xylyenebis(1-chloro-3-thiapropane) under conditions of high dilution. A series of novel, free-base, magnesium and zinc porphyrazines bearing macrocyclic substituents in peripheral positions were prepared via Linstead macrocyclization reactions of different maleonitrile derivatives, 12-nitro-4,7-bis(pyridin-2-ylmethyl)-2,3,4,7,8,9-hexahydro-1,10,4,7-benzodioxa-diaza-cyclododecine-5,6-dicarbonitrile or 5,8-bis(pyridin-2-ylmethyl)-1,3,4,5,8, 9,10,12-octa-hydro-2,11,5,8-benzodi-thiadiazacyclo-tetradecine-6,7-dicarbonitrile and the corresponding divalent metal salts. Pentanuclear copper(II) complexes were also prepared from the corresponding zinc(II) porphyrazine derivatives. The compounds were characterized by a combination of elemental analysis, FT-IR, UV-vis, H-1 NMR, C-13 NMR and MS spectral data. (c) 2008 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 37595-74-7 is helpful to your research. Computed Properties of C8H5F6NO4S2.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.603-11-2, Name is 3-Nitrophthalic acid, SMILES is O=C(O)C1=CC=CC([N+]([O-])=O)=C1C(O)=O, belongs to benzodioxans compound. In a document, author is WELL, M, introduce the new discover, COA of Formula: C8H5NO6.

SYNTHESIS AND NMR-SPECTROSCOPY OF PHOSPHORANES WITH 1,3,2-DIOXA-4,5-NAPHTHOPHOSPHOLE RING

The reaction of naphthalene-2,3-diol 1 with PCl3 was found to furnish the hydridophosphorane 3, with PCl5 the chlorophosphorane 4 was formed. The reaction of the fluorophosphoranes, RPF4 [R=F, (i)Pr, CH2SiMe3, CH2Cl, Ph] with the bis(trimethylsilyl) derivative of 1, 2 yielded the corresponding spirocyclic phosphoranes, 5-9 by cleavage of the Si-O bond and elimination of Me3SiF. The difluorophosphoranes, R2PF3 [R=Me, Ph] reacted with 2 to form the monocyclic phosphoranes, 10 and 11, where the fluorine atom occupies an axial position at trigonal-bipyramidal (TBP) phosphorus- The structure of compound 11 was confirmed by single crystal X-ray analysis of its dichloromethane hemisolvate at -95-degrees-C. The geometry at phosphorus is trigonal-bipyramidal. whereby the naphthalenedioxy ligand spans an axial and an equatorial site. Me2PF3 reacted with tetrakis(1,2,4.5-trimethylsiloxy)benzene to form the bifunctional benzodioxa-lambda5-phosphole, 12.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 603-11-2 is helpful to your research. COA of Formula: C8H5NO6.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, SMILES is CC1=C(C=CC=C1N(=O)=O)C(O)=O, belongs to benzodioxans compound. In a document, author is LUNDMARK, S, introduce the new discover, Product Details of 1975-50-4.

KINETICS, MECHANISMS, AND SYNTHESIS STUDIES OF RING-OPENING-CLOSING ALTERNATING COPOLYMERIZATION

The present paper describes the ring-opening-closing alternating copolymerization of cyclic phosphonites (2-phenyl-1,3,2-dioxaphospholane (1a), 2-phenyl-1,3,2-dioxaphosphorinane(1b), 2-phenyl-1,3,2-dioxaphosphepane(1c), and 2-phenyl-4H-1,3,2-benzodioxa phosphorin-4-one(1d) with muconic acid(2a), succinaldehyde(2b), glutaraldehyde(2c), adipinaldehyde(2d), o-phthalaldehyde(2e), acrylic anhydride(2f), methacrylic anhydride(2g), N-methyl diacrylamide(2h), and N-methyldimethacrylamide(2i). The reaction of a 1:1 monomer feed ratio, explained by a mechanism of propagation via zwitterion intermediates, proceeds without any added catalyst to give an alternating copolymer 3 involving ring-opening of 1 and ring-closing of 2. The structure of copolymer 3 was determined by H-1, C-13 NMR, P-31 NMR and IR spectroscopies as well as elemental analysis.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1975-50-4 is helpful to your research. Product Details of 1975-50-4.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 931-86-2, Name is 5-Azacytosine, molecular formula is C3H4N4O, belongs to benzodioxans compound. In a document, author is Bilgin, Ahmet, introduce the new discover, Quality Control of 5-Azacytosine.

Novel porphyrazines containing peripherally functionalized macrocyclic (N2O2, N2S2) units: Synthesis and characterization

Novel maleonitrile moieties were synthesized by cyclization of 2,3-bis[(2-pyridylmethyl)amino]-2(Z)-butene-1,4-dinitrile with 1,2-bis(2-iodoethoxy)-4-nitrobenzene or o-xylyenebis(1-chloro-3-thiapropane) under conditions of high dilution. A series of novel, free-base, magnesium and zinc porphyrazines bearing macrocyclic substituents in peripheral positions were prepared via Linstead macrocyclization reactions of different maleonitrile derivatives, 12-nitro-4,7-bis(pyridin-2-ylmethyl)-2,3,4,7,8,9-hexahydro-1,10,4,7-benzodioxa-diaza-cyclododecine-5,6-dicarbonitrile or 5,8-bis(pyridin-2-ylmethyl)-1,3,4,5,8, 9,10,12-octa-hydro-2,11,5,8-benzodi-thiadiazacyclo-tetradecine-6,7-dicarbonitrile and the corresponding divalent metal salts. Pentanuclear copper(II) complexes were also prepared from the corresponding zinc(II) porphyrazine derivatives. The compounds were characterized by a combination of elemental analysis, FT-IR, UV-vis, H-1 NMR, C-13 NMR and MS spectral data. (c) 2008 Elsevier Ltd. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 931-86-2. Quality Control of 5-Azacytosine.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of 2,3-Dihydrobenzo[b][1,4]dioxine493-09-4, Name is 2,3-Dihydrobenzo[b][1,4]dioxine, SMILES is C1COC2=C(O1)C=CC=C2, belongs to benzodioxans compound. In a article, author is Dettbarn, WD, introduce new discover of the category.

Different role of carboxylesterases in toxicity and tolerance to paraoxon and DFP

The contribution of carboxylesterase (CarbE) to toxicity and tolerance to the organophosphorus anticholinesterases; (OP-antiChE) paraoxon (diethyl p-nitrophenyl phosphate) and DFP (diisopropylphosphorofluoridate) was investigated in rats. Daily injections (20 days) of paraoxon (0.33 mu mol/kg) or DFP (2.72 mu mol/kg) reduced AChE activity in brain to 29 or 16% and in diaphragm to 58 or 54%, respectively. The animals tolerated an accumulated 6-fold LD50 dose and survived an LD90 dose of carbachol, indicating tolerance to this cholinergic agonist. A single dose of paraoxon or DFP significantly reduced CarbE activity of plasma, lung and liver. After paraoxon, rapid recovery was seen of plasma and liver CarbE while recovery after DFP was much slower. Daily pretreatment with the CarbE inhibitors CBDP (2-[o-cresyl]-4H-1,2,3-benzodioxa- phosphorin-2-oxide) (7.22 mu mol/kg, s.c.) or iso-OMPA (tetraisopropylpyrophosphoramide) (8.76 mu mol/kg, i.p.), followed by paraoxon (0.33 mu mol/kg, s.c.) 30 min later, prevented the development of tolerance to paraoxon and potentiated its toxicity. Rats died on day four of the combined treatment. The CarbE inhibitors neither potentiated the DFP toxicity, nor prevented tolerance development to DFP. We conclude that rat plasma CarbE provides a significant protection against paraoxon toxicity because its rapid reactivation can reduce the toxicity of repeated paraoxon applications and thus contribute to tolerance development. This same mechanism does not apply to DFP toxicity, as inhibition of CarbE of plasma, liver and lung neither potentiated its toxicity, nor prevented tolerance development. These findings confirm previous observations that CarbE detoxification is of greater importance for highly toxic OP-antiChEs such as nerve agents and paraoxon than for less toxic ones such as DFP. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 493-09-4. Quality Control of 2,3-Dihydrobenzo[b][1,4]dioxine.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Bilgin, Ahmet, once mentioned the application of 6226-25-1, Name is 2,2,2-Trifluoroethyltrifluoromethanesulfonate, molecular formula is C3H2F6O3S, molecular weight is 232.1, MDL number is MFCD00671579, category is benzodioxans. Now introduce a scientific discovery about this category, Recommanded Product: 2,2,2-Trifluoroethyltrifluoromethanesulfonate.

Novel porphyrazines containing peripherally functionalized macrocyclic (N2O2, N2S2) units: Synthesis and characterization

Novel maleonitrile moieties were synthesized by cyclization of 2,3-bis[(2-pyridylmethyl)amino]-2(Z)-butene-1,4-dinitrile with 1,2-bis(2-iodoethoxy)-4-nitrobenzene or o-xylyenebis(1-chloro-3-thiapropane) under conditions of high dilution. A series of novel, free-base, magnesium and zinc porphyrazines bearing macrocyclic substituents in peripheral positions were prepared via Linstead macrocyclization reactions of different maleonitrile derivatives, 12-nitro-4,7-bis(pyridin-2-ylmethyl)-2,3,4,7,8,9-hexahydro-1,10,4,7-benzodioxa-diaza-cyclododecine-5,6-dicarbonitrile or 5,8-bis(pyridin-2-ylmethyl)-1,3,4,5,8, 9,10,12-octa-hydro-2,11,5,8-benzodi-thiadiazacyclo-tetradecine-6,7-dicarbonitrile and the corresponding divalent metal salts. Pentanuclear copper(II) complexes were also prepared from the corresponding zinc(II) porphyrazine derivatives. The compounds were characterized by a combination of elemental analysis, FT-IR, UV-vis, H-1 NMR, C-13 NMR and MS spectral data. (c) 2008 Elsevier Ltd. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 6226-25-1, Recommanded Product: 2,2,2-Trifluoroethyltrifluoromethanesulfonate.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 887144-97-0, Name is 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, molecular formula is C10H10F3IO, belongs to benzodioxans compound. In a document, author is Keglevich, Gyoergy, introduce the new discover, Safety of 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole.

Platinum Complexes of Five- and Six-Membered P-Heterocycles as Potential Catalysts

5- and 6-Membered P-heterocycles including phosphines (1H-phospholes, 3-phospholenes, phospholanes, dihydro-and tetrahydrophosphinines), phosphinites (dibenzo[c. e][1,2]oxaphosphorines) and phosphonites (benzo[1,3,2]dioxaphospholanes), as well as, 3-P-substituted species 3-diphenylphosphino-1,2,3,6-tetrahydrophosphinine or 1,2,3,4,5,6-hexahydrophosphinine derivatives are surveyed as potential monodentate and bidentate P(III)-ligands in platinum(II)-complexes. The cis structures were assigned on the basis of stereospecific (1)J(P-31-Pt-195) NMR coupling constants. The catalytic effect of selected Pt(II)-complexes in hydroformylation is also summarized.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 887144-97-0. Safety of 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In an article, author is WELL, M, once mentioned the application of 1975-50-4, COA of Formula: C8H7NO4, Name is 2-Methyl-3-nitrobenzoic acid, molecular formula is C8H7NO4, molecular weight is 181.1455, MDL number is MFCD00007160, category is benzodioxans. Now introduce a scientific discovery about this category.

SYNTHESIS AND NMR-SPECTROSCOPY OF PHOSPHORANES WITH 1,3,2-DIOXA-4,5-NAPHTHOPHOSPHOLE RING

The reaction of naphthalene-2,3-diol 1 with PCl3 was found to furnish the hydridophosphorane 3, with PCl5 the chlorophosphorane 4 was formed. The reaction of the fluorophosphoranes, RPF4 [R=F, (i)Pr, CH2SiMe3, CH2Cl, Ph] with the bis(trimethylsilyl) derivative of 1, 2 yielded the corresponding spirocyclic phosphoranes, 5-9 by cleavage of the Si-O bond and elimination of Me3SiF. The difluorophosphoranes, R2PF3 [R=Me, Ph] reacted with 2 to form the monocyclic phosphoranes, 10 and 11, where the fluorine atom occupies an axial position at trigonal-bipyramidal (TBP) phosphorus- The structure of compound 11 was confirmed by single crystal X-ray analysis of its dichloromethane hemisolvate at -95-degrees-C. The geometry at phosphorus is trigonal-bipyramidal. whereby the naphthalenedioxy ligand spans an axial and an equatorial site. Me2PF3 reacted with tetrakis(1,2,4.5-trimethylsiloxy)benzene to form the bifunctional benzodioxa-lambda5-phosphole, 12.

Interested yet? Read on for other articles about 1975-50-4, you can contact me at any time and look forward to more communication. COA of Formula: C8H7NO4.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem