Day: February 20, 2021

Synthetic Route of 22013-33-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 22013-33-8, 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine, introducing its new discovery.

Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus

Alphaviruses are arthropod-transmitted members of the Togaviridae family that can cause severe disease in humans, including debilitating arthralgia and severe neurological complications. Currently, there are no approved vaccines or antiviral therapies directed against the alphaviruses, and care is limited to treating disease symptoms. A phenotypic cell-based high-throughput screen was performed to identify small molecules that inhibit the replication of Venezuelan Equine Encephalitis Virus (VEEV). The compound, 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(3-fluoro-4-methoxybenzyl)ethan-1-amine (1), was identified as a highly active, potent inhibitor of VEEV with an effective concentration for 90% inhibition of virus (EC90) of 0.89 muM and 7.49 log reduction in virus titers at 10 muM concentration. These data suggest that further investigation of compound 1 as an antiviral therapeutic against VEEV, and perhaps other alphaviruses, is warranted. Experiments suggested that the antiviral activity of compound 1 is directed at an early step in the VEEV replication cycle by blocking viral RNA and protein synthesis.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Related Products of 214894-89-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 214894-89-0, Name is 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine, molecular formula is C9H9BrO2. In a Article£¬once mentioned of 214894-89-0

Non-imidazole histamine H3 ligands. Part VI. Synthesis and preliminary pharmacological investigation of thiazole-type histamine H3-receptor antagonists with lacking a nitrogen nucleus in the side chain

Background: Antagonists to the H3 receptor are considered to be potential drugs for the treatment of Alzheimer’s disease, attention deficit-hyperactive disorder, memory and learning deficits, and epilepsy. The initial development of potent H3 receptor antagonists focused on extensive modification of the natural ligand histamine. However, it has appeared that imidazole-containing ligands are associated with inhibition of cytochrome P450 enzymes, caused by imidazole nitrogen complexation to heme iron in the active site of the enzyme. For these reasons, the development of potent non-imidazole H3 receptor antagonists was eagerly awaited. Objective: Previously, we reported the synthesis and pharmacological in vitro characterization of series of potent histamine H3-receptor non-imidazole antagonists belonging to the class of substituted 2-thiazol-4-n-propylpiperazines. A lead compound 1 of this family was a derivative carrying the ethylaminomethylpropyl chain. Methods: With the aim of increasing lipophilicity, that will help the ligands to cross the blood-brain barrier, we synthesized a series of new 2-thiazol-4-n-propylpiperazines where the ethylaminomethylpropyl moiety was replaced by a p-substituted-, an unsubstituted benzene ring, and omega-phenylalkyl substituent at positions 4 and 5 of thiazole ring, respectively. All compounds were tested for H3 antagonistic effects in vitro using the electrically contracting guinea pig jejunum. Results: The most active compounds of presented series 3d, 3e, and 3j showed lower affinity than the lead compound 1 and additionally, derivatives 3d and 3j possessed weak, competitive H1-antagonistic activity. This is in contrast to the lead compound 1 that has no affinity at H1 receptor. Conclusion: We can conclude that a side chain in the 2-thiazol-4-n-propylpiperazine scaffold should contain a basic center and should be present at a favorable position 5 of thiazole ring.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C8H9NO2. Introducing a new discovery about 22013-33-8, Name is 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

General synthesis of N-Alkylation of amines with secondary alcohols via hydrogen autotransfer

Direct catalytic N-alkylation of amines with secondary alcohols via hydrogen autotransfer (HA) strategy is very challenging and has been scarcely reported, even under precious metal catalysis. Herein, an efficient N-alkylation of amines, including benzylamines using secondary alcohols as alkylating agents, is reported. This reaction is catalyzed by a molecularly defined NNN-Ni(II) pincer complex, and the reaction operates under mild, benign conditions. Various substrates and functional groups were tolerated. Preliminary mechanistic studies suggest that the N-alkylation reaction proceeds via a hydrogen autotransfer mechanism.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C8H9NO2, you can also check out more blogs about22013-33-8

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 214894-89-0, Name is 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine, molecular formula is C9H9BrO2

Selective switchable iron-catalyzed hydrosilylation of carboxylic acids

Selective reduction of carboxylic acids either to aldehydes or alcohols is achieved using a one pot procedure based on iron-catalyzed hydrosilylations. Using phenylsilane and (COD)Fe(CO)3 catalyst under UV-irradiation at rt, alcohols were obtained specifically in good yields, whereas aldehydes were selectively obtained using TMDS and (t-PBO)Fe(CO)3 catalyst under thermal activation.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 214894-89-0, in my other articles.

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C8H9NO2. Introducing a new discovery about 22013-33-8, Name is 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

Reduction of 3-(carboxyaryl)isocoumarins with sodium borohydride

Reduction of 3-(carboxyaryl)isocoumarins with sodium borohydride proceeds with formation of corresponding 3-carboxyaryl-3,4-dihydroisocoumarins or isomeric dihydrophthalides, 3-(2-carboxybenzyl)-2-benzofuran-1(3H)-ones. Derivatives at the carboxyl group of 3-carboxyaryl-3,4-dihydroisocoumarins and 3-(2-carboxybenzyl)-2-benzofuran-1(3H)-ones have been obtained. 0009-3122/12/4710-12122012 Springer Science+Business Media, Inc.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C8H9NO2, you can also check out more blogs about22013-33-8

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid. Introducing a new discovery about 4442-53-9, Name is 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid

3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS

The invention relates to 3-aza-bicyclo[3.3.0]octane derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as orexin receptor antagonists.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

70918-54-6, Name is (S)-1,4-Benzodioxane-2-carboxylic acid, belongs to benzodioxans compound, is a common compound. Product Details of 70918-54-6In an article, once mentioned the new application about 70918-54-6.

Photocatalytic Aminodecarboxylation of Carboxylic Acids

Aminodecarboxylation of unactivated alkanecarboxylic acids has been accomplished utilizing an organic photocatalyst. This operationally simple reaction utilizes readily available carboxylic acids to chemoselectively generate reactive alkyl intermediates that are not accessible via conventional two-electron pathways. The organic radical intermediates are efficiently trapped with electrophilic diazo compounds to provide aminated alkanes.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Related Products of 4442-59-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 4442-59-5, (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanamine, introducing its new discovery.

ASYMMETRIC SYNTHESIS OF ORGANOELEMENTAL ANALOGS OF NATURAL COMPOUNDS. 7. (2R,3S)-2-AMINO-3-HYDROXY-5-PHOSPHONOVALERIC ACID

The reaction of the Ni(II) complex of the Schiff base of glycine with (S)-2-N-(N1-benzylprolyl)-o-aminobenzophenone with diethyl-3-bromo-2-hydroxypropyl phosphonate yields the corresponding complex from which (2R,3S)-2-amino-3-hydroxy-5-phosphonovaleric acid is separated with HCl. Keywords: asymmetric synthesis, (S)-2-N-(N1-benzylprolyl)-o-aminobenzophenone, (2R,3S)-2-amino-3-hydroxy-5-phosphonovaleric acid.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 4442-59-5. In my other articles, you can also check out more blogs about 4442-59-5

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Related Products of 2879-20-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2879-20-1, Name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, molecular formula is C10H10O3. In a Article£¬once mentioned of 2879-20-1

The alpha-chlorination of aryl methyl ketones under aerobic oxidative conditions

The novel reaction system air/ammonium nitrate/iodine/hydrochloric acid [air/NH4NO3(cat.)/I2(cat.)/HCl] is introduced as a simple, safe, cheap, efficient and regioselective mediator for the alpha-chlorination of aryl, heteroaryl and alkyl methyl ketones under aerobic oxidative conditions. The inventive use of a catalytic amount of iodine enabled the moderate to quantitative, regioselective chlorination of a comprehensive scope of different methyl ketone derivatives including those bearing oxidizable heteroatom (S, N) substituents, some of which possess declared potential biological and pharmaceutical activity. Air oxygen under a slight overpressure plays the role of the terminal oxidant catalytically activated by redox cycles of nitrogen oxides released from the catalytic amount of ammonium nitrate (NH4NO3) under acidic conditions of hydrochloric acid (HCl) and co-catalyzed by elemental iodine (I2), which was found to be essential for the high efficiency of the reaction system.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2879-20-1

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of Ethyl 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 261767-10-6

Benzofuran derivatives, their preparation and use

The present invention relates to benzofuran derivatives having general Formula (I) 1wherein A is selected from (1), (2), (3), (4) 2wherein Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C26-alkynyl, C1-6-alkyl-aryl, or C1-6-alkyl-O-aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene; its enantiomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT1A receptor.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem