Day: November 13, 2020

As a common heterocyclic compound, it belong benzodioxans compound,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,4442-54-0,Molecular formula: C9H8O4,mainly used in chemical industry, its synthesis route is as follows.,4442-54-0

Compound 239, N-(2-bromo-5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)phenyl)-2-methylquinoline-6-carboxamide[00332] To a suspension of 2,3-dihydrobenzo[b][1 ,4]dioxine-6-carboxylic acid(1 .001 g, 5.56 mmol) in dry DCM (20 mL), DMF (0.972 muIota, 0.013 mmol) and oxalyl chloride (0.513 mL, 6.06 mmol) were added dropwise and the resulting green solution was allowed to stir at 20 ¡ãC for 3 hours after which it was concentrated under vacuum to afford a dry pale green solid. The solid was dissolved in pyridine (20.00 mL) and Lambda/-(5- amino-2-bromophenyl)-2-methylquinoline-6-carboxamide (1 .80 g, 5.05 mmol) was added in one portion. The resulting dark yellow suspension was allowed to stir for 72 hours after which it was poured onto water. The yellow precipitate was filtered and washed several times with water, Et20 and finally with a minimum amount of DCM to afford the crude product as a pale yellow solid which does not require further purification (2.1 1 g, 81 percent).1H-NMR (500 MHz, DMSO): delta 10.29 (s, 1 H), 10.27 (s, 1 H), 8.63 (s, 1 H), 8.42 (d, J =9.1 1 Hz, 1 H), 8.25 (d, J = 7.29 Hz, 1 H), 8.10 (s, 1 H), 8.05 (d, J = 8.20 Hz, 1 H), 7.69 (bs, 2H), 7.58-7.49 (m, 3H), 6.99 (d, J = 9.1 1 Hz, 1 H), 4.37-4.27 (m, 4H), 2.71 (s, 3H). HRMS (ESI+): Found [M+H]+520.0723 C26H21BrN3O4 requires 520.0693.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,belong benzodioxans compound

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid, cas is 4442-54-0, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.,4442-54-0

General procedure: 2,3-Dihydrobenzo[b]-[1,4] dioxinecarboxylic acid A, B and C (10 mmol) in ethanol (200 mL) was treated with thionyl chloride (5 mL) under reflux overnight. Excess ethanol was distilled out and the solid left was dissolved in ethyl acetate (150 mL), washed with saturation sodium bicarbonate (200 mL) and then sodium chloride (200 mL). After drying the organic layer with anhydrous Na2SO4 and evaporating the solvent under reduced pressure and solid appeared. The solid was recrystallized from ethanol to obtain the compound A1, B1 and C1. The completion of the reaction was monitored on TLC by using silica gel-G coated plates by using ethyl acetate and petroleum ether (1 : 1) as the elution and observed in UV light.

With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid

Reference£º
Article; Song, Xiaoda; Yang, Yushun; Zhao, Jing; Chen, Yangjian; Chemical and Pharmaceutical Bulletin; vol. 62; 11; (2014); p. 1110 – 1118;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belong benzodioxans compound,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,2879-20-1,Molecular formula: C10H10O3,mainly used in chemical industry, its synthesis route is as follows.,2879-20-1

General procedure: Acetophenone 1a (120 mg, 1.0 mmol), pyridine 2a (158 mg, 2.0 mmol), and iodine (254 mg, 1.0 mmol) were placed in an oven-dried and argon filled Schlenk tube. After addition of anhydrous DMSO (5 mL), the mixture was stirred at 100 C for 36 h. After the reaction completed, the mixture was diluted with water and treated with Na2S2O3 (5% w/w, aq) until the color turned to pale yellow. The mixture was then extracted with CH2Cl2 (3¡Á20 mL), the combined organic extracts were dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (eluent: CH2Cl2/EtOAc=200:1) to afford a yellow solid 3aa (122 mg, 85%).

With the synthetic route has been constantly updated, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,belong benzodioxans compound

Reference£º
Article; Yang, Yan; Gao, Meng; Zhang, Dong-Xue; Wu, Liu-Ming; Shu, Wen-Ming; Wu, An-Xin; Tetrahedron; vol. 68; 36; (2012); p. 7338 – 7344;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid, and cas is 4442-54-0, its synthesis route is as follows.,4442-54-0

Compound benzodioxane-6-carboxylic acid (0401-119) (500 mg, 2.78 mmol, 1 eq.)Dissolved in 15 ml of methanol,Then slowly add 1.5 ml of thionyl chloride,The mixture was stirred at reflux for 2 hours.After the reaction was completed, the mixture was concentrated under reduced pressure.Ester and water extraction, the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the target compound benzodiMethyl hexacycline-6-carboxylate (538 mg, yield: 99.26percent) was a yellow solid.

With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.6 (3,5-Bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone (C6) White crystal, mp: 144-146 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.12-3.18 (d, J = 16.8 Hz, 1H), 3.69-3.76 (m, 1H), 3.82 (s, 6H), 4.31-4.33 (t, J = 2.4 Hz, 4H), 5.72-5.77 (m, 1H), 6.83-6.90 (m, 3H), 7.19-7.23 (m, 2H), 7.43-7.46 (m, 1H), 7.59 (s, 1H), 7.71-7.74 (d, J = 8.1 Hz, 2H), 7.82-7.84 (d, J = 7.2 Hz, 2H). MS (ESI): 445.17 (C26H25N2O5, [M+H]+). Anal. Calcd for C26H24N2O5: C, 70.26; H, 5.44; N, 6.30; O, 18.00. Found: C, 69.97; H, 5.44; N, 6.32., 4442-54-0

The synthetic route of 4442-54-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 2879-20-1, its synthesis route is as follows.,2879-20-1

General procedure: A mixtureof substituted acetophenone (0.02 mol) and dimethylformamide-dimethylacetal (DMF-DMA) (II) (0.023 mol)was reAuxed for 12 h under solvent-free condition on aheating mantle, and then, the mixture was left to cool slowlyat room temperature. +e precipitate was obtained. Diethylether was added to the precipitate, and 6ltration was performedunder vacuum. +e obtained product was recrystallizedfrom absolute ethanol [24].

With the complex challenges of chemical substances, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone

Reference£º
Article; Bhat, Mashooq Ahmad; Al-Omar, Mohamed A.; Naglah, Ahmed M.; Khan, Abdul Arif; Bonomo, Maria Grazia; Journal of Chemistry; vol. 2019; (2019);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: NEt3 (0.57?mL, 4.00?mmol) was added dropwise to a suspension of 3-methoxyphenylacetic acid (0.60?g, 4.00?mmol) and [Ti(eta5-C5H5)2Cl2] (0.50?g, 2.00?mmol) in toluene (50?mL) at room temperature. The reaction mixture colour changed immediately from deep red to orange and was then stirred for 3?h at 80?¡ãC. The mixture was decanted and filtered to remove the triethylammonium chloride salt. The filtrate was then concentrated and cooled to ?30?¡ãC to give orange crystals of the complex which were isolated by filtration.

4442-54-0, The synthetic route of 4442-54-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ceballos-Torres, Jesu?s; Caballero-Rodri?guez, Mari?a J.; Prashar, Sanjiv; Paschke, Reinhard; Steinborn, Dirk; Kaluerovic?, Goran N.; Go?mez-Ruiz, Santiago; Journal of Organometallic Chemistry; vol. 716; (2012); p. 201 – 207;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

It is a common heterocyclic compound, the benzodioxans compound, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1 its synthesis route is as follows.,2879-20-1

General procedure: To 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one(A) (1 mmol) alcohol solution (5 mL) was added substituted benzaldehyde(1 mmol). After dissolution, 50% NaOH (0.5 mL) was added. After confirming the completion of the reaction by thin layer chromatography, the sediment was filtered, washed with ethanol and dried to obtain chalcone

With the complex challenges of chemical substances, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone

Reference£º
Article; Yang, Yu-Shun; Yang, Bing; Zou, Yan; Li, Guigen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 3052 – 3061;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belong benzodioxans compound,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,4442-54-0,Molecular formula: C9H8O4,mainly used in chemical industry, its synthesis route is as follows.,4442-54-0

Preparation of Compound 181, N-(4-chloro-3-nitrophenyl)-2,3- dihydrobenzo[b][1,4]dioxine-6-carboxamide[00247] Oxalyl chloride (0.141 mL, 1 .665 mmol) was added dropwise to a solution of 1 ,4-benzodioxane-6-carboxylic acid (250 mg, 1 .388 mmol) and DMF (2.69 mu, 0.035 mmol) in dry DCM (7 mL). The reaction was allowed to stir at room temperature for 2 h. The reaction mixture was concentrated, a further portion of dry DCM (7 ml) was added and concentrated again. This residue was re-dissolved in dry DCM (3 + 3 +1 mL) and added drop-wise to a solution of 4-chloro-3-nitroaniline (239 mg, 1 .388 mmol) and pyridine (0.224 mL, 2.78 mmol) in dry DCM (7 mL). The reaction was allowed to stir for 3 h at room temperature. The solvent was removed in vacuo and the resulting residue was suspended in MeOH and a solid precipitated by addition of water. The precipitate was isolated by filtration and washed with water, then dried under high vacuum to afford the title compound as a dark yellow solid (417 mg, 90percent). 1H NMR (500 MHz, DMSO-d6) delta 10.54 (s, 1 H), 8.59 (d, J= 2.5 Hz, 1 H), 8.05 (dd, J = 8.9, 2.5 Hz, 1 H), 7.75 (d, J = 8.9 Hz, 1 H), 7.59 – 7.46 (m, 2H), 7.02 (d, J = 8.4 Hz, 1 H), 4.35 – 4.28 (m, 6H). HRMS (ESI+): calcd for C15H12ClN2O5 (M + H)+, 335.0435; found 335.0437.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,belong benzodioxans compound

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belong benzodioxans compound,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,3663-80-7,Molecular formula: C9H8O4,mainly used in chemical industry, its synthesis route is as follows.,3663-80-7

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.18 (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone (D3) White crystal, mp: 223-225 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.20-3.24 (d, J = 10.2 Hz, 1H), 3.71-3.80 (m, 1H), 3.87 (s, 3H), 4.42-4.45 (m, 1H), 4.51-4.54 (d, J = 6.9 Hz, 1H), 5.57-5.60 (m, 1H), 5.62-5.63 (m, 1H), 6.82-6.89 (m, 3H), 6.95-6.97 (d, J = 5.1 Hz, 2H), 7.00-7.02 (d, J = 5.4 Hz, 1H), 7.22-7.26 (m, 3H), 7.30-7.33 (m, 2H), 7.69-7.71 (d, J = 5.4 Hz, 2H). MS (ESI): 415.16 (C25H23N2O4, [M+H]+). Anal. Calcd for C25H22N2O4: C, 72.45; H, 5.35; N, 6.76; O, 15.44. Found: C, 72.18; H, 5.34; N, 6.79.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,belong benzodioxans compound

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem