Application of Vinylferrocene

2879-20-1, As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

The benzodioxans compound, cas is 2879-20-1 name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, mainly used in chemical industry, its synthesis route is as follows.

General procedure: Carbonyl substrate, 0.02 mol, was added in portions to a suspension of 0.01 mol NaBH4 in 0.3 mol of the corresponding alcohol solvent, and the mixture was stirred for 2-2.5 h at 20C. The resulting boron derivatives of benzyl alcohols were decomposed with 10% aqueous HCl (3.7 mL), and the mixture was stirred for a required time at a required temperature(see Tables 1-5), cooled, and poured into 200 mL of cold water. The products were extracted with diethylether (2 ¡Á 40 mL), the combined extracts were washed with water and dried over anhydrous sodium sulfate, the solvent was distilled off on a rotary evaporator, and the residue was analyzed by 1H NMR. If necessary,benzyl ethers were isolated by chromatography. Alcohol coreactants poorly soluble in water were removed from the diethyl ether extracts by vacuum distillation, and the target ethers ware isolated from the still residue. Ethers 2a [9], 2c [3], 2h, 4a [10], 4b [11], 4i,4l, 7e, 10c, 10d, 10e [4], and 13a [12] were described previously. Ethers 2b, 2d-2g, 2i, 4c-4h, 4j, 4k, 4m-4w, 7a-7d, 7f, 7g, and 13b-13f are mobile liquids, and 7h-7j, 10a, 10b, and 10f-10i are viscous liquids.

2879-20-1, As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Review; Mochalov; Fedotov; Trofimova; Zefirov; Russian Journal of Organic Chemistry; vol. 52; 4; (2016); p. 503 – 512; Zh. Org. Khim.; vol. 52; 4; (2016); p. 503 – 512,10;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Application of 3-Piperazinobenzisothiazole hydrochloride

4442-53-9, With the rapid development of chemical substances, we look forward to future research findings about 4442-53-9

The benzodioxans compound, cas is 4442-53-9 name is 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid, mainly used in chemical industry, its synthesis route is as follows.

A.5.1 Synthesis of (IS^S.SRJ^-facylamino-methylJ-S-aza-bicycloIS.S.O]- octane-3-carboxylic acid tert. -butyl ester derivatives (general procedure)To a solution of the respective carboxylic acid R3-COOH (1 eq) in DMF (0.2 mmol/ 0.5 mL) are added successively DIPEA (5 eq) and TBTU (1 eq). The reaction mixture is stirred for 15 min. at RT and then is added a solution of (1S,2S,5R)-1- aminomethyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid te/t.-butyl ester derivative (1 eq) in DMF (0.5 ml_). The stirring at RT is continued for 16 h, the reaction mixture is poured into water and diluted with EA. The org. phase is washed with sat. NaHCOs solution and water. After drying over anh. MgSO4 and removal of solvents in vacuo the desired compounds are obtained which are used without further purification.(1S,2S,5R)-2-{[(3,4-Dihydro-benzo[1 ,4]dioxine-5-carbonyl)-amino]-methyl}-3- aza-bicyclo[3.3.0]octane-3-carboxylic acid tert. -butyl esterprepared by reaction of (I S^S.SR^I-aminomethyl-S-aza-bicyclobeta.S.OJ-octane-S- carboxylic acid te/t-butyl ester with commercially available 2,3-dihydro- benzo[1 ,4]dioxine-5-carboxylic acid.LC-MS: tR = 1.00 min; [M+H]+ = 403.

4442-53-9, With the rapid development of chemical substances, we look forward to future research findings about 4442-53-9

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/4584; (2009); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Application of 5-Bromo-1,2,3,4-tetrahydroisoquinoline

4442-53-9, With the rapid development of chemical substances, we look forward to future research findings about 4442-53-9

The benzodioxans compound, cas is 4442-53-9 name is 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid, mainly used in chemical industry, its synthesis route is as follows.

Intermediate 35: 2-diazo-1-(2,3-dihvdro-1 ,4-benzodioxin-5-yl)ethanone; A solution of 1 g of 2,3-dihydro-1 ,4-benzodioxin-5-carboxylic acid (5.55 mmole, Aldrich) in 30.7 mL of SOCI2 was stirred at 850C for 1 h in a dry flask under nitrogen atmosphere. The excess of SOCI2 was removed under reduced pressure, the resulting crude oil was dissolved in 20.3 ml. of MeCN and to this solution, a solution of TMSCHN2 2M in hexane (11.1 mmole, Aldrich) was added dropwise at O0C. The reaction mixture was warmed to RT and stirred for 2 h. A 1 M solution of citric acid was added and then extracted with AcOEt. The organic layer was washed with a saturated solution of NaHCC>3, dried over Na2SO4 and concentrated under reduced pressure. The crude oil was purified by flash chromatography (from CH to CH/AcOEt 80/20) to give the title compound as a yellow oil (489 mg, 42percent). 1H-NMR (500 MHz, CDCI3): delta 4.29-4.34 (2H, m), 4.35-4.40 (2H, m), 6.25 (1 H, s), 6.92 (1 H, t), 7.02 (1 H, dd), 7.46 (1 H, s); m/z (ES): 205 [M+H]+.

4442-53-9, With the rapid development of chemical substances, we look forward to future research findings about 4442-53-9

Reference£º
Patent; GLAXO GROUP LIMITED; WO2008/148853; (2008); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Application of 8-Chloro-3-methoxy-1,5-naphthyridine

2879-20-1, With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

The benzodioxans compound, cas is 2879-20-1 name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, mainly used in chemical industry, its synthesis route is as follows.

General procedure: Finely powdered CuO (0.8 g, 10.0 mmol) and I2 (2.53 g, 10.0 mmol) were added to a solution of aryl methyl ketone 9a (1.2 g, 10.0 mmol) in anhydrous MeOH (20 mL). The mixture was refluxed for 1-2.5 h. After disappearance of aryl methyl ketone 9a (monitored by TLC), the mixture was filtered and the solvent was removed under reduced pressure. The residue was poured into 10% Na2S2O3 solution (50 mL), the mixture was extracted with EtOAc (3 ¡Á 50 mL), and the organic layer was dried (Na2SO4). Removal of the solvent and purification of the residue by column chromatography gave the desired product 1a in 96% yield.

2879-20-1, With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Zhu, Yan-Ping; Cai, Qun; Gao, Qing-He; Jia, Feng-Cheng; Liu, Mei-Cai; Gao, Meng; Wu, An-Xin; Tetrahedron; vol. 69; 31; (2013); p. 6392 – 6398;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Application of 1-Methylimidazolidin-2-one

2879-20-1, With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

The benzodioxans compound, cas is 2879-20-1 name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, mainly used in chemical industry, its synthesis route is as follows.

The title compound was prepared according to the published protocol1. A 60 % suspension of sodium hydride in mineral oil (0.2 g, 5.0 mmol) was washed with petroleum benzin (20 ml) twice, anhydrous DMSO (4 ml) was added. After being stirred for 30 mm at room temperature under argon, the flask was cooled down to 15 00 and a solution of methyl3-chlorobenzoate (0.853 g, 5.0 mmol) and 1 -(2,3-dihydro-1 ,4-benzodioxin-6-yl)ethanone (0.712 g, 4.0 mmol) in DMSO (4 ml) was added dropwise. Upon completion of addition, the reaction mixture was stirred 24 h at room temperature, then poured slowly into crushed ice (50 g) containing 85 % phosphoric acid (1 ml). The resulting precipitate was collected by filtration, washed with water (50 ml) and air dried. The resulting crude product wasrecrystallized from methanol to provide sery595 (590 mg, 47 %) as a light-yellow powder.TLC (hexane:EtOAc, 3/1 v/v): RE = 0.53.1H NMR (400 MHz, DMSO-d6) 6 = 8.24 (t, J = 1.8 Hz, 1H), 8.10 (d, J = 7.8 Hz, 1H), 7.79-7.73(m, 2H), 7.69 (m, 1H), 7.58 (t, J 7.8 Hz, 1H), 7.32 (s, 1H), 7.02 (d, J = 8.3 Hz, 1H), 4.39-4.29 (m, 4H), (in 1H NMR spectrum 6.5% of diketone form is present).130 NMR (100.6 MHz, DMSO-d6) 6 = 186.2, 181.6, 148.1, 143.5, 136.6, 133.8, 132.4, 130.7,127.8, 126.9, 125.8, 121.7, 117.4, 116.7, 93.1, 64.6, 63.9.LC MS (RP18-100A, gradient 0% CH3CN/100% H20 – 100% CH3CN in 50 mm), RT 45.8 mm and mass 317.04 (100%), 318.99 (35%) ([M+H]).M.p. 106-1 07 C.

2879-20-1, With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; LUDWIG-MAXIMILIANS-UNIVERSITAeT MUeNCHEN; GEORG-AUGUST-UNIVERSITAeT GOeTTINGEN; BECKER, Dorothea; JOVIN, Thomas M.; GRIESINGER, Christian; LEONOV, Andrei; RYAZANOV, Sergey; GIESE, Armin; OUTEIRO, Tiago F.; LAZARO, Diana F.; SCHOeN, Michael P.; SCHOeN, Margarete; (101 pag.)WO2018/206778; (2018); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Introduction of a new synthetic route about 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde

29668-44-8, With the rapid development of chemical substances, we look forward to future research findings about 29668-44-8

2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde, cas is 29668-44-8, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

General procedure: To a solution of 2-nitro-benzaldehyde 1a,b or benzaldehyde 4a,b (20 mmol) in methanol (15 mL) was added dropwise solution of hydroxylamine hydrochloride (40 mol) in water (10 mL) at room temperature in 30 min. Aqueous solution of sodium hydroxide (0.4 mol) was then added dropwise to the solution and the sulting mixture was stirred for 30-60 min at room temperature. Afterwards, solvent was removed under reduced pressure, the residue was quenched in crushed ice/water (10 mL) and the pH was adjusted to ~ 4 with acetic acid 50 %. The formed precipitate was isolated, washed with cold water (20 mL) and n-hexane (30 mL), and dried at 50C to afford corresponding oxime derivatives 2a,b or 5a,b, which were used for the next step without further purification.

29668-44-8, With the rapid development of chemical substances, we look forward to future research findings about 29668-44-8

Reference£º
Article; Le-Nhat-Thuy, Giang; Dinh, Thuy Van; Pham-The, Hai; Nguyen Quang, Hung; Nguyen Thi, Nga; Dang Thi, Tuyet Anh; Hoang Thi, Phuong; Le Thi, Tu Anh; Nguyen, Ha Thanh; Nguyen Thanh, Phuong; Le Duc, Trung; Nguyen, Tuyen Van; Bioorganic and Medicinal Chemistry Letters; vol. 28; 23-24; (2018); p. 3741 – 3747;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Simple exploration of 3663-80-7

3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The dipeptides after appropriate deprotection and the amino acid methyl esters were coupled with 1,4-benzodioxane-2-carboxylic acid using DCC as acoupling reagent and TEA as a base in different reaction conditions like microwave, sonication, refluxing and conventional methods to give the desired products (2a-2e) (Scheme-2)., 3663-80-7

3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various.

Reference£º
Article; Malipeddi, Himaja; Gowda, Visruth; Das, Moonjit; Indian Journal of Heterocyclic Chemistry; vol. 25; 2; (2015); p. 113 – 118;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Some tips on 2879-20-1

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various.

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2879-20-1

General procedure: Equimolar quantities of substituted benzaldehyde and 1-(2H-1,3-benzodioxol-5-yl)ethan-1-one or 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one were dissolved in 40% KOH and ethanol. The reactionmixture was then stirred for 10 h and poured into ice-cold water. Theprecipitated product was washed with water, dried, and recrystallizedfrom ethanol.

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various.

Reference£º
Article; Parambi, Della Grace Thomas; Oh, Jong Min; Baek, Seung Cheol; Lee, Jae Pil; Tondo, Anna Rita; Nicolotti, Orazio; Kim, Hoon; Mathew, Bijo; Bioorganic Chemistry; vol. 93; (2019);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Brief introduction of 2879-20-1

2879-20-1, The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: To 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one(A) (1 mmol) alcohol solution (5 mL) was added substituted benzaldehyde(1 mmol). After dissolution, 50% NaOH (0.5 mL) was added. After confirming the completion of the reaction by thin layer chromatography, the sediment was filtered, washed with ethanol and dried to obtain chalcone

2879-20-1, The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yang, Yu-Shun; Yang, Bing; Zou, Yan; Li, Guigen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 3052 – 3061;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

New learning discoveries about 20197-75-5

As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20197-75-5

To a solution of compound A(0.1 mol) in ethanol (50 mL) was added 85% hydrazine hydrate (1 mL) and the mixture was refluxed for 8-10 h. The reaction mixture was cooled down and the precipitated solid was filtered off and washed with small quantity of ethanol to give intermediate compound B.

As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Article; Wang; Liu; Xu; Sun; Russian Journal of General Chemistry; vol. 87; 11; (2017); p. 2671 – 2677; Zh. Obshch. Khim.; vol. 87; 11; (2017); p. 2671 – 2677,7;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem