Day: August 27, 2020

(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine, cas is 17413-10-4, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

General procedure: A 15mL capped tube was charged with intermediate 11 (64 mg,0.2 mmol) and corresponding amine (1.0 mmol). The degassed isopropanol (5 mL) was added. The tube was flushed with argon,capped, and heated at 140 C for 12-48 h. After cooling to roomtemperature, the reaction mixture was concentrated in vacuum,and the residue was purified by column chromatography (EtOAc:PE = 1:2) to give the target compounds 6a-r.

With the rapid development of chemical substances, we look forward to future research findings about 17413-10-4

Reference£º
Article; Li, Peng; Wang, Bin; Zhang, Xinwei; Batt, Sarah M.; Besra, Gurdyal S.; Zhang, Tingting; Ma, Chen; Zhang, Dongfeng; Lin, Ziyun; Li, Gang; Huang, Haihong; Lu, Yu; European Journal of Medicinal Chemistry; vol. 160; (2018); p. 157 – 170;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: To 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one(A) (1 mmol) alcohol solution (5 mL) was added substituted benzaldehyde(1 mmol). After dissolution, 50% NaOH (0.5 mL) was added. After confirming the completion of the reaction by thin layer chromatography, the sediment was filtered, washed with ethanol and dried to obtain chalcone

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Article; Yang, Yu-Shun; Yang, Bing; Zou, Yan; Li, Guigen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 3052 – 3061;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol, cas is 274910-19-9, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol (533 mg, 3.20 mmol) is dissolved in chloroform (4 mL), pyridine (0.11 mL) and thionyl chloride (0.7 mL, 9.7 mmol) is added little by little and the mixture is stirred at room temperature for 1 hour. The reaction solution is added with water and extracted with dichloromethane, and the organic layer is washed with aqueous sodium hydrogen carbonate solution. The organic layer is dried, the solvent is distilled off under reduced pressure, and pale yellow liquid of 578 mg is obtained in 97% yield.

With the rapid development of chemical substances, we look forward to future research findings about 274910-19-9

Reference£º
Patent; KANTO KAGAKU KABUSHIKI KAISHA; ABE, Jiro; INAGAKI, Yuki; SUGA, Takayoshi; NAGASAWA, Hiroto; US2020/131193; (2020); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: A series of sixteen novel 1, 4-benzodioxane-based thiosemicarbazones(3a-p) was synthesized by reacting appropriatethiosemicarbazide (1a-p) (5 mmol) and 1, 4-benzodioxan-6-ylmethyl ketone (2) (5 mmol) in methanol (15 mL) using glacialacetic acid (1e2 drops) as catalyst. Reflux at 80 C for 6 h wascarried out and the product formation and the reaction completion were examined by thin layer chromatography. Upon completion,the reaction mixturewas allowed to cool at r.t and the solid productwas collected by suction filtration followed by washing with hotmethanol and then dried in vacuum. Finally, the target thiosemicarbazonesderivatives were recrystallized from chloroformmethanolmixture (1:1) in good to excellent yields. The X-raymeasurements were read by mounting a 3m single crystal on agreased MiTe Gen loop and was inspected through thediffractometer (Bruker D8 Venture APEX diffractometer) at 296 (2)K by means of graphite-monochromated MoeK a radiation(l 0.71073 A); diffractometer was complimented with an areadetector (Photon 100 CCD) along with a cooler (Oxford Cryostream).APEX-II software was used to collect Data [41] and SAINTwas operated for integration [42] The SADABS (multi-scanapproach) was used for correction in absorption [43]. and intrinsicphasing (SHELXT)was employed to the solve the structure [44]. Fullleast squares refinement of all detected reflections were used todetermine the final cell constants and assign positions of all atomsother than H to the consequential difference maps via refinementagainst F2. Whereas H atoms were assigned location and addedagainst F2 and were refined by riding model. SHELXL-97 wasimplemented to refine anisotropically [45]. The CCDC (CSD depositionnumbers 1874544) of the structure has been deposited. Thedetailed characterization of compounds 3a e 3p are given insupporting informations.

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Article; Shehzad, Muhammad Tariq; Khan, Ajmal; Islam, Muhammad; Hameed, Abdul; Khiat, Mohammed; Halim, Sobia Ahsan; Anwar, Muhammad U.; Shah, Syed Raza; Hussain, Javid; Csuk, Rene; Khan, Samra; Al-Harrasi, Ahmed; Shafiq, Zahid; Journal of Molecular Structure; vol. 1209; (2020);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

To a solution of 1 ,4-benzodioxan-2-carboxylic acid (0.216 g, 1.2 mmol) in N, N- dimethylformamide (5.0 mL) were added 2,2-diphenylethanamine (0.197 g, 1.0 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.186 g, 1.2 mmol) and 1- hydroxybenzotriazole (0.162 g, 1.2 mmol). The resulting mixture was stirred at ambient temperature for 16 h. To the above mixture was added ethyl acetate (100 ml_), the resultant solution was washed with 2 N citric acid (50 ml_), saturated sodium bicarbonate (50 ml_) and brine (50 ml_). The organic layer was dried over anhydrous sodium sulfate, then filtered and concentrated to give the crude product. The crude product was recrystalized from ether and hexane to yield lambda/-(2,2-diphenylethyl)-2,3- dihydro-1 ,4-benzodioxine-2-carboxamide (0.326 g, 91percent) as a colorless solid: 1H NMR (300 MHz, CDCI3) 5 7.33-7.11 (m, 10H), 6.89-6.68 (m, 4H), 6.49 (s, 1 H), 4.59 (dd, J = 6.6, 2.7 Hz, 1 H), 4.39 (dd, J = 11.3, 2.7 Hz, 1 H), 4.17-3.97 (m, 3H), 3.90-3.78 (m, 1H); 13C NMR (75 MHz, CDCI3) delta 167.1 , 143.2, 141.4, 141.3, 128.7, 128.7, 128.0, 127.9, 126.9, 122.2, 121.9, 117.6, 117.0, 73.2, 65.0, 50.5, 43.2; MS (ES+) m/z 382.1 (M + 23), 360.1 (M + 1 ).

With the rapid development of chemical substances, we look forward to future research findings about 3663-80-7

Reference£º
Patent; XENON PHARMACEUTICALS INC.; WO2008/106633; (2008); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

Example 11 1-butyl-2,5-dioxo-3-(2-methylpropyl)-9-(1-(1,4-benzodioxan-6-yl)ethyl)-1,4,9-triazaspiro[5.5]undecane ¡¤ hydrochloride Under an atmosphere of argon, to a solution of the compound prepared in Example 9 (315 mg) in dichloromethane (5 ml) were added 1,4-benzodioxan-6-yl methyl ketone (285 mg), triethylamine (0.354 ml) and a solution of titanium tetrachloride in dichloromethane (1.0 M, 0.63 ml). The reaction mixture was stirred for 16 hours at room temperature. To the reaction mixture was added a solution of sodium cyanoborohydride (133 mg) in methanol (2 ml). The reaction mixture was stirred for 1 hour at room temperature. To the reaction mixture was added 2N aqueous solution of sodium hydroxide, and was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated. The obtained residue was purified by column chromatography on silica gel (Fuji Silysia Chemical Ltd., BW235; chloroform: methanol = 50: 1). The obtained residue was dissolved in methanol. The solution was acidified by adding 1 N hydrochloric acid, and was concentrated to give the compound of the present invention (176 mg) having the following physical data. TLC: Rf 0.46 (chloroform: methanol = 10:1); NMR (CD3OD): delta 7.04 (d, J = 2.1 Hz, 1H), 6.98 (dd, J = 8.4, 2.1 Hz, 1H), 6.92 (d, J = 8.4 Hz, 1H), 4.40 (q, J = 6.9 Hz, 1H), 4.26 (s, 4H), 3.98 (dd, J = 8.1, 4.5 Hz, 1H), 3.82-3.17 (m, 6H), 2.55-2.04 (m, 4H), 1. 87-1.28 (m, 10H), 1.04-0.85 (m, 9H).

With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1236726; (2002); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine, cas is 17413-10-4, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

To a solution of fers-butyl (25)-2-{[(6-methoxy-l,5-naphthyridin-4-yl)amino]carbonyl}- 5-oxopiperidine-l -carboxylate (1.19 g) in dichloroethane (50 mL) were added l-(2,3-dihydro- l,4-benzodioxin-6-yl)methanamine (0.60 g) and sodium cyanoborohydride (NaCNBH3) (0.42 g). After stirring at room temperature 60 hours, the reaction was concentrated. This residue was purified by flash chromatography using a FlashMaster using ethylacetate and hexane as eluants yielding 0.45 g of the title compound. ES (M+H)+=550.

With the rapid development of chemical substances, we look forward to future research findings about 17413-10-4

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/125974; (2006); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of acetophenone 1 (1a 120 mg, 1.0 mmol), 2 (2a, 216 mg, 2.0 mmol), 3 (3a, 260 mg, 2.0 mmol), TfOH (375 mg, 2.5 mmol) and iodine (25.4 mg, 0.1 mmol) in DMSO (4 mL), the mixture was stirred at 140 C till almost completed conversion of the substrates by TLC analysis, the mixture was quenched with saturation Na2S2O3 solution (50 mL), extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (eluent: petroleum ether/EtOAc=8/1) to afford the product 4 (4a-4x).

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various.

Reference£º
Article; Zhao, Peng; Wu, Xia; Geng, Xiao; Wang, Can; Wu, Yan-Dong; Wu, An-Xin; Tetrahedron; vol. 74; 32; (2018); p. 4323 – 4330;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-53-9,2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 106a (S)-ethyl 4-amino-5-(2-(2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamido)-3-methylbutoxy)-2-methylquinoline-3-carboxylate Prepared as in Example 24a from (S)-ethyl 4-amino-5-(2-amino-3-methylbutoxy)-2-methylquinoline-3-carboxylate (Example 95b) and 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid as brown solid (36%). MS 494 (MH+).

4442-53-9 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid 78184, abenzodioxans compound, is more and more widely used in various.

Reference£º
Patent; SENOMYS, INC.; US2011/245353; (2011); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

General procedure: A mixture of acetophenone 1a(0.5 mmol), acetonitrile 2 (7.5 mmol), and I2 (0.75 mmol) in DMSO (2mL) was stirred at 110 C. After disappearance of the reactant (monitored by TLC), added 50 mL water to the mixture, then extracted with EtOAc 3 times. The extract was washed with Na2S2O3 solution, dried over anhydrous Na2SO4 and evaporation. The residue was puriedby column chromatography to afford 3a.

With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Gao, Qinghe; Liu, Shan; Wu, Xia; Wu, Anxin; Tetrahedron Letters; vol. 55; 47; (2014); p. 6403 – 6406;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem