Day: August 26, 2020

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethanone (XV) (11 mmol), dimethylamine hydrochloride (14 mmol), paraformaldehyde (16 mmol) and 12 N HCl (2 drops) in ethanol (5 mL) was refluxed overnight. The solution was cooled to room temperature and the ethanol was evaporated under vacuum. The residue was treated with ethyl acetate, heated slightly and sonicated to disperse into fine particles. The solids were filtered and dried at room temperature to produce 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(dimethylamino)propan-1-one (XVI) as a white solid, (82% yield), 1H NMR (CDCl3, 400 MHz): delta ppm 2.77 (s, 6H), 3.41 (m, 2H), 3.56 (m, 2H), 4.25 (m, 4H), 6.85 (m, 1H), 7.45 (m, 2H).

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Patent; WINTHERIX, LLC; US2012/46320; (2012); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

General procedure: A series of sixteen novel 1, 4-benzodioxane-based thiosemicarbazones(3a-p) was synthesized by reacting appropriatethiosemicarbazide (1a-p) (5 mmol) and 1, 4-benzodioxan-6-ylmethyl ketone (2) (5 mmol) in methanol (15 mL) using glacialacetic acid (1e2 drops) as catalyst. Reflux at 80 C for 6 h wascarried out and the product formation and the reaction completion were examined by thin layer chromatography. Upon completion,the reaction mixturewas allowed to cool at r.t and the solid productwas collected by suction filtration followed by washing with hotmethanol and then dried in vacuum. Finally, the target thiosemicarbazonesderivatives were recrystallized from chloroformmethanolmixture (1:1) in good to excellent yields. The X-raymeasurements were read by mounting a 3m single crystal on agreased MiTe Gen loop and was inspected through thediffractometer (Bruker D8 Venture APEX diffractometer) at 296 (2)K by means of graphite-monochromated MoeK a radiation(l 0.71073 A); diffractometer was complimented with an areadetector (Photon 100 CCD) along with a cooler (Oxford Cryostream).APEX-II software was used to collect Data [41] and SAINTwas operated for integration [42] The SADABS (multi-scanapproach) was used for correction in absorption [43]. and intrinsicphasing (SHELXT)was employed to the solve the structure [44]. Fullleast squares refinement of all detected reflections were used todetermine the final cell constants and assign positions of all atomsother than H to the consequential difference maps via refinementagainst F2. Whereas H atoms were assigned location and addedagainst F2 and were refined by riding model. SHELXL-97 wasimplemented to refine anisotropically [45]. The CCDC (CSD depositionnumbers 1874544) of the structure has been deposited. Thedetailed characterization of compounds 3a e 3p are given insupporting informations.

With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Shehzad, Muhammad Tariq; Khan, Ajmal; Islam, Muhammad; Hameed, Abdul; Khiat, Mohammed; Halim, Sobia Ahsan; Anwar, Muhammad U.; Shah, Syed Raza; Hussain, Javid; Csuk, Rene; Khan, Samra; Al-Harrasi, Ahmed; Shafiq, Zahid; Journal of Molecular Structure; vol. 1209; (2020);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid, cas is 4442-53-9, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

Example 8 Synthesis of 4-{2-[(2,3-Dihydro-benzo[1,4]dioxine-5-carbonyl)-amino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide (Table 2, Compound 110) 4-(2-Amino-benzooxazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (1 eq) and 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid (1 eq) were dissolved in DMF. To this solution were added DIPEA (3 eq) and [dimethylamino-([1,2,3]triazolo[4,5-b]pyridin-3-yloxy)-methylene]-dimethyl-ammonium hexafluoro phosphate (1 eq). The mixture was stirred at 40¡ã C. overnight, then diluted with ethyl acetate and washed once each with 1N HCl, saturated aqueous sodium bicarbonate, and brine, and finally dried with anhydrous sodium sulfate, filtered, and concentrated. This was purified by preparatory reverse phase HPLC. MH+=447.0.

With the rapid development of chemical substances, we look forward to future research findings about 4442-53-9

Reference£º
Patent; Novartis AG; US2008/45528; (2008); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

The title compound was prepared according to the published protocol4. A mixture of 1-(2,3- dihydro-1,4-benzodioxin-6-yI)ethanone (890 mg, 5.0 mmol) and HDNIB (2.81 g, 6.0 mmol) in acetonitrile (50 ml) was heated under reflux for 2.5 h. 3-bromobenzamide (3.0 g, 15 mmol) was added in one portion and stirring was continued for additional 12 h with reflux. After cooling to room temperature, solvent was evaporated under reduced pressure. DOM(100 ml), water (50 ml) and saturated aq. NaHCO3 solution (50 ml) were added to the residual solid. The organic phase was separated, washed with water (50 ml), brine (20 ml), dried over Na2SO4, filtered and evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel (DCM/n-hexane = 2:1 v/v) to provide sery534 (700 mg, 39%) as a white solid.TLC (DCM/n-hexane, 2:1 v/v): RF = 0.52.1H NMR (400 MHz, DMSO-d6) = 8.63 (s, 1 H), 8.14 (t, J = 1.8 Hz, 1 H), 8.01 (d, J 7.9 Hz,1 H), 7.74 (d, J = 7.9 Hz, I H), 7.51 (t, J 7.9 Hz, 1 H), 7.38-7.31 (m, 2H), 6.93 (d, J = 8.2 Hz,1H), 4.28 (s, 4H).130 NMR (100.6 MHz, DMSO-d6) 6 = 159.2, 143.6, 143.5, 140.9, 135.2, 133.3, 131.4, 128.8,128.3, 125.0, 123.8, 122.3, 118.4, 117.4, 113.9, 64.2, 64.1.LC MS (RP18-100A, gradient 0% CH3CNI100% H20 -¡Â 100% CH3CN in 50 mm), RT 45.2mm and mass 358.09 (100%), 359.98 (100%) ([M+H]).M.p. 125-126 00.

With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; LUDWIG-MAXIMILIANS-UNIVERSITAeT MUeNCHEN; GEORG-AUGUST-UNIVERSITAeT GOeTTINGEN; BECKER, Dorothea; JOVIN, Thomas M.; GRIESINGER, Christian; LEONOV, Andrei; RYAZANOV, Sergey; GIESE, Armin; OUTEIRO, Tiago F.; LAZARO, Diana F.; SCHOeN, Michael P.; SCHOeN, Margarete; (101 pag.)WO2018/206778; (2018); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29668-44-8,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde,as a common compound, the synthetic route is as follows.

25 g of the product of Example 1,Adding 500 mL of water to raise the temperature to 70-80 DEG C,Then, 30 g of KMnO4 + 500 mL of an aqueous solution was prepared,Dropping into the above reaction solution, heating for 40 minutes and heating to reflux for 2 hours,The reaction was terminated by TLC, cooled to room temperature, alkalified by addition of 10percent aqueous KOH,Filter cake washed with water to neutral, the filtrate acidified with concentrated hydrochloric acid,A large amount of white solid was precipitated, and the filter cake was washed with water and dried to obtain 23 g of a white solid in 90percent yield.

29668-44-8 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde 248127, abenzodioxans compound, is more and more widely used in various.

Reference£º
Patent; Shanghai PharmValley Corp.; Yu, Weiyong; Yang, Ling; Wang, Ailing; (4 pag.)CN105801556; (2016); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: Carbonyl substrate, 0.02 mol, was added in portions to a suspension of 0.01 mol NaBH4 in 0.3 mol of the corresponding alcohol solvent, and the mixture was stirred for 2-2.5 h at 20C. The resulting boron derivatives of benzyl alcohols were decomposed with 10% aqueous HCl (3.7 mL), and the mixture was stirred for a required time at a required temperature(see Tables 1-5), cooled, and poured into 200 mL of cold water. The products were extracted with diethylether (2 ¡Á 40 mL), the combined extracts were washed with water and dried over anhydrous sodium sulfate, the solvent was distilled off on a rotary evaporator, and the residue was analyzed by 1H NMR. If necessary,benzyl ethers were isolated by chromatography. Alcohol coreactants poorly soluble in water were removed from the diethyl ether extracts by vacuum distillation, and the target ethers ware isolated from the still residue. Ethers 2a [9], 2c [3], 2h, 4a [10], 4b [11], 4i,4l, 7e, 10c, 10d, 10e [4], and 13a [12] were described previously. Ethers 2b, 2d-2g, 2i, 4c-4h, 4j, 4k, 4m-4w, 7a-7d, 7f, 7g, and 13b-13f are mobile liquids, and 7h-7j, 10a, 10b, and 10f-10i are viscous liquids.

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various.

Reference£º
Review; Mochalov; Fedotov; Trofimova; Zefirov; Russian Journal of Organic Chemistry; vol. 52; 4; (2016); p. 503 – 512; Zh. Org. Khim.; vol. 52; 4; (2016); p. 503 – 512,10;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

The 178mg (1mmol) 6- acetyl-1,4-benzo-dioxane, 80mg (2mmol) sodium hydroxide was placed in 50mLSingle neck flask was added 10mL of ethanol and dissolved; the 280mg (0.97mmol) 2- fluoro -4- (9- (9H- carbazol-yl))Benzaldehyde was dissolved in 10mL of dichloromethane, ethanol and added dropwise to the mixture, stirred at room temperature overnight, filtered,Ethanol, washed with petroleum ether and dried to give a pale yellow solid (LJZ-6-18) 386mg, 89% yield.

The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Institute of Materia Medica Chinese Academy of Medical Sciences; Xiaozhi, Yan; Ye, Fei; Guo, Zongru; Tianjin, Ying; Liu, Junzheng; Zhang, Shuen; Nie, Feilin; Tao, Rongya; Zhang, Xiaolin; Liu, Junchang; He, Yibo; Ma, Yiming; (36 pag.)CN102382037; (2016); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of coptisine (250 mg, 0.70 mmol) in 5 N NaOH (1 ml), 6-acetyl-1,4-benzodioxane (1 mL,6.67 mmol) was added slowly. The reaction mixture was stirred at 60C for 3 h. The reaction mixture was extracted withCHCl3/MeOH (v/v = 10:1). The organic layer was washed to neutral with water, and dried over anhydrous MgSO4, andfiltered, and then concentrated under reduced pressure to give intermediate product. The intermediate product wasdissolved in anhydrous tetrahydrofuran (5 mL) followed by addition of HOAc (0.5 mL) and formaldehyde (1.5 mL, 15.06mmol) dropwise. The reaction mixture was kept refluxing for 3 h. After the reaction completed, the reaction mixture wasconcentrated and added with 2 N HCl (2 mL), then stirred at room temperature for 1 h and extracted with CHCl3/MeOH(v/v = 10:1). The organic layer was dried over anhydrous MgSO4 and then filtered and concentrated under reducedpressure to give crude product, which was purified via silica gel column chromatography (CHCl3/MeOH (v/v) =20:1) togive pure yellow solid (110 mg, 28.1% yield).1H-NMR (DMSO-d6) delta: 2.95 (s, 3H, ArCH3), 2.99-3.14 (m, 2H, NCH2CH2), 4.37 (br d, J= 9.0 Hz, 4H, O CH2CH2O), 4.54(br s, 2H, NCH2CH2), 6.19 (s, 2H, OCH2O), 6.24 (s, 1H, OCH2O), 6.44 (s, 1H, OCH2O), 6.86 (s, 1H, C=CH2), 6.99 (s,1H, C=CH2), 7.10 (d, J = 8.4 Hz, 1H, ArH),7.17 (s, 1H, ArH), 7.44 (s, 1H, ArH), 7.45 (d, J = 2.1 Hz, 2H, ArH), 7.54 (dd,J1 = 8.4 Hz, J2 = 2.1 Hz, 1H, ArH), 8.07 (s, 2H, ArH).

The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Institute of Mataria Medica, Chinese Academy of Medical Sciences; QIN, Hailin; WANG, Wenjie; ZHANG, Zhihui; WU, Lianqiu; DENG, Anjun; YU, Jinqian; LI, Zhihong; EP2789612; (2014); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

General procedure: A mixture of acetophenone 1a (120 mg, 1.0 mmol), benzylamine 2a (160.7 mg, 1.5 mmol), and iodine (507.6 mg, 2.0 mmol) in DMSO (3 mL) was stirred at 100 C for 5 h. After disappearance of the reactant (monitored by TLC), and added 50 mL water to the mixture, then extracted with EtOAc three times (3 50 mL). The extract was washed with 10% Na2S2O3 solution (w/w), dried over anhydrous Na2SO4 and evaporation. The residue was purified by column chromatography on silica gel (petroleum ether/EtOAc=100:1) to yield the desired product 3aa as a white solid (183.4 mg, 83% yield).

With the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Gao, Qing-He; Fei, Zhuan; Zhu, Yan-Ping; Lian, Mi; Jia, Feng-Cheng; Liu, Mei-Cai; She, Neng-Fang; Wu, An-Xin; Tetrahedron; vol. 69; 1; (2013); p. 22 – 28;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem